New in MBoC A study in budding yeast shows that timely release of mRNAs from the RNA-binding protein Rim4 is essential for meiotic exit, preventing cells from re-entering the cell cycle after meiosis II. https://www.molbiolcell.org/doi/10.1091/mbc.E25-08-0379

From MBoC A new localization atlas maps more than 600 Giardia proteins, revealing the locations of hundreds of previously uncharacterized proteins and creating a valuable resource for functional discovery. https://www.molbiolcell.org/doi/10.1091/mbc.E25-12-0590

Recently published in MBoC Researchers identified an Arl8b–RUFY4–HOPS pathway that controls lysosome maturation and positioning in osteoclasts, revealing how these cells coordinate bone resorption. https://www.molbiolcell.org/doi/10.1091/mbc.E25-08-0412

Ready to move beyond traditional organoids? Learn how assembloids are creating better models of human disease in this free ASCB webinar featuring Hans Clevers. 📅 July 29 https://www.ascb.org/ascb-meetings/from-organoids-to-assembloids-building-better-models-of-human-disease/

From MBoC Optogenetic activation of RhoA reveals a direct mechanism for local septin recruitment. The findings show that RhoA signaling—not myosin contractility—drives septin remodeling in interphase cells. https://www.molbiolcell.org/doi/10.1091/mbc.E25-09-0468

New in MBoC How do cells regulate microtubule stability during mitosis? Researchers found that microtubules have smaller GTP caps during mitosis than in interphase, revealing a cell-cycle-regulated mechanism for tuning microtubule dynamics. https://www.molbiolcell.org/doi/10.1091/mbc.E26-01-0054

Your next presentation starts with an abstract. You now have until August 4 to submit your Cell Bio 2026 talk or poster abstract. Share your research and join the conversations shaping the future of cell biology. https://www.ascb.org/cellbio2026/

Available in MBoC A yeast study shows that depletion of the ribosomal protein Rpl32 disrupts ribosome biogenesis & triggers G1 arrest. Surprisingly, translation remains efficient, revealing links between ribosome assembly & cell cycle control. https://www.molbiolcell.org/doi/10.1091/mbc.E25-10-0479

From MBoC What gives YAP condensates their function? This study identifies JUNB and TCF12 as essential components of YAP condensates. Loss of either factor blocked condensate assembly and YAP-dependent gene activation during stress. https://www.molbiolcell.org/doi/10.1091/mbc.E25-11-0532

Congratulations to ASCB LGBTQ+ Committee member Katelyn Cooper and her coauthors on publishing "LGBTQ+ Realities in the Biological Sciences" in CBE—Life Sciences Education. https://ascb-prod.literatumonline.com/eprint/6EZZ8YWMHXPFVTKWAXFV/full

White House draft regulations could reshape federally funded research, including peer review and international collaborations. Learn what's proposed and why it matters. Comments due July 13. https://www.ascb.org/science-policy/white-house-draft-regulations-could-reshape-american-science/

Published in MBoC Copper deficiency is not one disease state. Comparing CTR1- & COX17-deficient cells, researchers found distinct AMPK/mTOR signaling responses and different survival strategies downstream of compartment-specific copper defects. https://www.molbiolcell.org/doi/10.1091/mbc.E26-01-0021

From MBoC Using human engineered heart tissues, researchers modeled iron overload cardiomyopathy and found that iron impairs cardiac function through oxidative damage and direct inhibition of myosin. https://www.molbiolcell.org/doi/10.1091/mbc.E26-02-0063

Published in MBoC A study in Clytia hemisphaerica reveals how epithelial tissues coordinate multiple wound-healing mechanisms across different wound sizes. The work identifies basement membrane exposure as a key regulator of repair responses. https://www.molbiolcell.org/doi/10.1091/mbc.E26-02-0094

Now available in MBoC Membrane lipids help shape nutrient uptake. This study shows that the yeast ER–vacuole tether Mdm1 maintains sphingolipid balance needed for proper regulation of the methionine transporter Mup1 during nutrient stress. https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0111

From MBoC Faithful meiosis requires more than APC/C activity—it also requires degradation of the APC/C activator Cdh1. Yeast studies reveal how nutrient sensing regulates this process and supports accurate chromosome segregation. https://www.molbiolcell.org/doi/10.1091/mbc.E24-07-0286

Don’t miss this MBoC Highlight on Quantitative Cell Biology June 22 | 12 PM ET Keynote: Jennifer Lippincott-Schwartz Register: https://www.ascb.org/ascb-meetings/mboc-highlight-quantitative-cell-biology-with-keynote-by-jennifer-lippincott-schwartz/

Call for Papers: Cell Biology of the Nucleus Submit your research on nuclear organization, genome regulation, and stem cell biology to MBoC’s special focus. Rolling submissions are now open. Learn more and submit: molbiolcell.org/nucleus-stem-cells

Organoids, engineered tissues, & other 3D models are reshaping tumor microenvironment research. Learn how during ASCB’s free webinar on June 17 at 1 PM ET. Open to ASCB members & nonmembers. Register: https://www.ascb.org/ascb-meetings/unlocking-tumor-microenvironment-biology-with-3d-tissue-models/

Need more time to submit your research? The #CellBio2026 abstract submission deadline has been extended, giving you additional time to submit abstracts for talks and posters. Learn more and submit: https://www.ascb.org/cellbio2026/

Editor Spotlight: Erin Goley “MBoC provides an ideal venue for bacterial and archaeal cell biologists to share their findings with the broader cell biology community, with constructive peer review and fast turnaround.” Learn more about publishing in MBoC: molbiolcell.org

Editor Spotlight: Amy Gladfelter Duke University “MBoC welcomes interdisciplinary work addressing fundamental cell biology, offers a thoughtful review process, and provides space for discussion about our scientific culture.” Explore the journal and submission opportunities at molbiolcell.org

Scientific breakthroughs don’t happen in isolation. Even Nobel laureates rely on their community. Marty Chalfie continues to attend Cell Bio because it strengthens his science—and his connections. Be part of the community at Cell Bio 2026. https://www.ascb.org/cellbio2026/

Call for Papers: Cell Biology of the Lysosome Submit your research to MBoC’s special focus on lysosome biology. Benefit from constructive peer review, fast decisions, and wide visibility. Submit your manuscript: molbiolcell.org/lysosome

Editor Spotlight: Aurnab Ghose “MBoC emphasizes rigor and transparency, publishing high-quality cell biology without vanity criteria. Scientists from the global south benefit from its fair and constructive publishing ethics.” Learn more about publishing in MBoC: molbiolcell.org

How do biomolecular condensates regulate cellular function — and contribute to disease? Explore the latest research during ASCB’s webinar on June 3, 2026, at 11:00 am ET. Register: https://www.ascb.org/ascb-meetings/phase-separation-biomolecular-condensates-from-mechanism-medicine/

Editor Spotlight: Tatsuo Fukagawa Osaka University “MBoC papers are widely read by experts and recognized as a high standard work.” Explore the journal and submission opportunities at molbiolcell.org

New from MBoC MCTP1 and MCTP2 promote ER–PM contact sites and regulate PI4P levels, linking lipid homeostasis to cell migration. https://www.molbiolcell.org/doi/10.1091/mbc.E25-09-0445

Editor Spotlight: Lillian Fritz-Laylin University of Massachusetts “MBoC welcomes manuscripts on unique biology, diverse organisms, and important but often overlooked areas of cell biology.” Explore the journal and submission opportunities at molbiolcell.org

New from MBoC RUFY4 links Arl8b to lysosome maturation and trafficking in osteoclasts, revealing key mechanisms driving bone resorption. https://www.molbiolcell.org/doi/10.1091/mbc.E25-08-0379