Eric Topol
@erictopol
physician-scientist, author, editor Ground Truths SUPER AGERS
Against all odds, with an HHS that has defunded mRNA research programs, the FDA just approved the first mRNA flu vaccine
Consistent with this recent report of killer T cells directed to virus antigens (Epstein Barr, CMV) in people with Long Covid www.cell.com/cell-reports...
Less protein, more lifespan! A comprehensive review of the merits of protein restriction for healthy aging A flip from the proteinmaxxing craze cell.com/cell-press-b...
Coverage at NY Times front page, gift link www.nytimes.com/2026/07/23/h... and my input to that piece
Around the world, life expectancy is increasing but the gap vs healthspan is widening. That is, more sickspan. The US has the largest morbidity gap. Let that sink in: The US has the largest morbidity gap. www.thelancet.com/journals/lan...
"Perhaps the worst blow to food safety science was the administration’s elimination of the National Advisory Committee on Microbiological Criteria for Foods, a group of experts whose recommendations have informed many major food safety programs." gift link www.nytimes.com/2026/07/20/o...
GLP-1 drugs helped people with diabetes to prevent pulmonary fibrosis, #LongCovid Work in patients and the mouse model. Open-access journals.asm.org/doi/full/10....
Long Covid persistent eye symptoms can be debilitating and appear to be related to chronic T-cell mediated neuroinflammation. open-access www.nature.com/articles/s41...
For treatment and outcomes for cancer, the tumor microenvironment is pivotal, but we've never had a non-invasive way to assess it. Until now, a blood test breakthrough! With sequencing >10 million cells + AI, discovery & validation of a blood test that informs response to therapy and prognosis.
On our 250th birthday, celebrating the contribution of immigrants and international collaboration —46% of people with doctoral-level degrees working in US science and engineering fields are foreign-born
Trust in science in the United States @nature.com by @helenpearson.bsky.social www.nature.com/articles/d41...
A comprehensive assessment of the safety of mRNA vaccines thelancet.com/journals/lan...
Two of the most important biomedical breakthroughs came from science of the Gila lizard venom (GLP-1s) and yogurt (CRISPR genome editing). "The system that turned that lizard into a medicine is now being dismantled." gift link nytimes.com/2026/06/20/o...
In defiance of Koch's postulates that establish a causal relationship between a microbe and a disease.
Beginning July 1st, $50/month for Ozempic or Zepbound for all Medicare Part D enrollees sounds great. But here's the truth and it's not very good at all. by @dusetzinas.bsky.social @nejm.org today nejm.org/doi/full/10....
Academic freedom assessment across the world. The US is on a steep decline, below >120 countries www.scientificamerican.com/article/see-...
A @nejm.org editorial today on the Office of White House Management and Budget (OMB) regarding their new funding proposal and politicization of science www.nejm.org/doi/full/10....
An exemplar of molecular prevention of cancer Reviewed in the new Ground Truths. All content is free, no ads. erictopol.substack.com/p/a-new-path...
Discovery of a 14-protein biomarker that predicts lung cancer 5.6 years before it is diagnosed, even in non-smokers, and an anti-inflammatory medicine that prevents its progression. And, challenging dogma, the proteins are not coming from cancerous cells!
He takes 325 mg/day. His doctors recommend 80 mg/day, not evidence-based. The hazard of low-dose aspirin (100 mg) people 65+, reviewed in SUPER AGERS A significant excess of all-cause deaths (14% more), deaths from cancer (31% higher), and major bleeding events (38% higher) in the aspirin group
For your birthday, Mr. President, we got you 22 medical specialists, lots of tests, and a very favorable write-up www.washingtonpost.com/politics/202...
A life-threatening inherited disease, hereditary angioedema, with striking benefit from one-shot CRISPR genome editing. Phase 3 randomized, double-blind trial results @nejm.org www.nejm.org/doi/full/10....
For medical information, general AI frontier models (Google, OpenAI, Anthropic) outperformed specialized @openevidence.bsky.social and UptoDate AI Assessed by 12 US clinicians, randomized & model blinded w/extensive testing/benchmarks. This was not anticipated nature.com/articles/s41...
No, the peptide craze is not backed by science. "What people are shooting up with out there I would give to mice." “The influencer crowd has sort of created this perception that these are miracle drugs." New feature @nature.com nature.com/articles/d41...
The suppressed report that concluded there is no protective or safe level of alcohol consumption, now published. It was commissioned by US Congress Report jsad.com/doi/10.15288... Editorial jsad.com/doi/epdf/10.... "Despite the study’s adherence to its mandate, its findings were sidelined.”
Good assessment of 4 wearables in this N of 1 study by @nicnguyen.bsky.social of Oura, Whoop, Fitbit Air, and Apple Watch gift link wsj.com/tech/persona...
Two of the most powerful technologies we've ever known—CRISPR human embryo editing and self-improving A.I.—are getting actualized, and carry known and unforeseen risks nytimes.com/2026/06/04/s... wsj.com/tech/ai/anth... @anthropicai.bsky.social
An infographic I made with @notebooklm.bsky.social to help convey what was done here (a lot!)