Bring your group, lab, or team to #IASP2026. Groups of five or more receive 10% off registration when submitted together and paid in one transaction. Join the global pain community in Bangkok, 26–30 October: bit.ly/4qx0aOI

Rosenbloom et al. find that psychological interventions can reduce pain intensity, pain interference, and trauma-related symptoms in people with chronic pain and co-occurring trauma symptoms, with benefits lasting up to 6 months. Learn more in #PAIN bit.ly/3TcW8Ql

Klyne et al. find that postinjury sleep disturbance promotes neuroimmune changes that prolong pain, while aerobic exercise reverses these effects and supports recovery. Learn more in #PAIN bit.ly/3SWsf6N

In this week’s #PAIN Featured Image, Stratton et al. explain how pre-operative prevention of psychological stress-induced sensitization of nociceptors in women can help prevent post-operative pain. Learn more at bit.ly/44bAVbY

A meta-analysis by Mullins et al. of functional brain response to painful stimulation in areas involved in secondary mechanical hyperalgesia revealed increased activation in areas involved in pain modulation. Learn more in #PAIN bit.ly/44Fva6x

An @IASP.bsky.social Task Force and external experts used pairwise ranking to prioritize candidate clinical features to discriminate between predominant nociceptive, neuropathic, and nociplastic pain. Learn more in #PAIN bit.ly/3STPFK4

Fernández-Morales et al. report that chronic musculoskeletal pain is associated with reduced heart rate variability and impaired vagal regulation, with distinct autonomic patterns across pain conditions such as fibromyalgia and regional pain. Learn more in #PAIN bit.ly/4vdQlrf

@nkytang.bsky.social et al.’s network models reveal how mental defeat dynamically shapes daily pain experiences by increasing attention to pain and perceived impact on routine, relationships, self-identity, and future. Learn more in #PAIN bit.ly/4wdf1kC

In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict circular RNA dysregulation associated with opioid exposure in human DRG. Altered circRNA expression may contribute to opioid-associated molecular adaptations in nociceptors. Learn more at bit.ly/4wizmEW

Veinot et al. find that patients with chronic pain and high post-traumatic stress symptom show decreased working memory brain activity and have stronger connections to threat-related brain regions under high cognitive load. Learn more in #PAIN bit.ly/4wFTSjp

Kelleher et al. find that neuropathic-like pain symptoms at diagnosis predict worse pain outcomes in early rheumatoid arthritis. This association is independent of inflammatory activity and supported by neuroimaging evidence. Learn more in #PAIN bit.ly/447WKsU

Lee et al. find that anterior midcingulate cortex responses during pain catastrophizing predicted distinct trajectories of cognitive behavioral therapy response, a neural marker for guiding personalized intervention strategies in fibromyalgia #PAIN bit.ly/4v45Stt

Gilliam et al. find that cerebellar gray matter alterations in chronic low back pain link reduced crus I volume to impaired postural control and show lobule-specific associations with pain sensitivity. Learn more in #PAIN bit.ly/4wevAMW

This week’s #PAIN Featured Image showcases the June cover art, derived from Padfield and Zakrzewska’s essay on using images to help people understand and communicate their lived experiences of pain. Learn more at bit.ly/4ek7oBF

Galosi et al. show that QST phenotypes correspond to distinct patterns of peripheral nerve damage in painful polyneuropathy, supporting mechanism-based patient stratification. Learn more in #PAIN bit.ly/4ekIkdI

Muwanga et al.’s holistic assessment of naturalistic and nocifensive behaviors parses alpha2-mediated analgesia from sedation in mice after tibial fracture-cast injury. Learn more in #PAIN bit.ly/4ejc3Uj

Huang et al. report that preinjury physical and psychological vulnerabilities may contribute to poor outcomes following minor to moderate car crash injuries. In particular, preinjury pain doubles the odds of acute and chronic postinjury pain #PAIN bit.ly/4aLD1mr

Roman-Juan et al. assert that chronic pain in migrant youth is shaped by structural inequities and the trauma of migration, calling for trauma-informed care alongside policies that address the social determinants of health. Learn more in #PAIN bit.ly/4fCbPKl

Ide et al. evaluate the TG-Vo pathway for its role in the orofacial neuropathic pain development using a rat model with partial ligation of the infraorbital nerve. Learn more in #PAIN bit.ly/4fLo4o1

Li et al. find that oncostatin M induced prolonged mechanical, but not thermal, hypersensitivity in male and female rats and elicited robust action potential discharges in cultured rat DRG neurons. Learn more in #PAIN bit.ly/4eknvPq

Rönnegård et al. find that chronic widespread pain is associated with a substantially higher risk of atherosclerotic cardiovascular disease, highlighting the need for proactive cardiovascular risk assessment. Learn more in #PAIN bit.ly/4fAELSV

In this week’s #PAIN Featured Image, Fernández-Trillo et al. depict results suggesting Piezo2 is not critical for epidermal innervation by MrgprD+ nonpeptidergic fibers, but may play a role in their precise organization/distribution in the subepidermal region bit.ly/4fYYJaj

Lv et al. find that hM4D(Gi) activation using adeno-associated virus-retro as the vector and delivered via bladder injection to bladder-innervating DRG can effectively inhibit neurons and alleviate pain and overactive bladder in mice. Learn more in #PAIN bit.ly/4ehIxyh

Hooten et al.’s prospective case-controlled study offers novel insights into the behavioral pain responses and characteristics associated with UPOU in surgical and nonsurgical patients. Learn more in #PAIN bit.ly/4egXuQX

Rubanets et al. find that verbal modeling, counterconditioning, and operant conditioning equally reduced nocebo hyperalgesia. Expectancies mediated induction, but attenuation of nocebo hyperalgesia involved expectancies only under operant conditioning. Learn more in #PAIN bit.ly/4egcyhR

In their secondary analysis, Edlund et al. find that behavioral interventions for pain modestly reduced opioid use in high-dosage patients; baseline dosage was the strongest predictor of reduction. Learn more in #PAIN bit.ly/4vJxTaH

Help IASP name the #2026WorldCongressonPain ambassador! For this year’s World Congress, we are introducing a Thai elephant ambassador to advocate for cultural and scientific exchange while bringing an extra spirit of fun to the event. Vote by 6 July: bit.ly/4uOrQkj

Luo et al. find that TWIK-related acid-sensitive K+ channel 3 activation reduces sensory neuron excitability and alleviates acute and chronic itch, supporting its potential as a novel therapeutic target. Learn more in #PAIN bit.ly/4entIdv

Swipe to see how you can help shape the future of pain science! Join Painhack 2026 in Bangkok and collaborate with global experts, researchers, clinicians, and people with lived experience to tackle real-world pain challenges: bit.ly/4qx0aOI #IASP2026

Birkinshaw et al. find that pain-related distress may be identified in musculoskeletal pain through clinical conversations covering optimism, patient history, perceived stress, and 4DSQ questionnaire scores. Learn more in #PAIN bit.ly/4emlUc4