The Lancet

@thelancet

Welcome to The Lancet, one of the world’s leading medical journals, published weekly since 1823. 🌐 thelancet.com

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The Lancet@thelancet· 20h

Identifying glaucoma patients at risk of rapid progression is crucial to preventing vision loss. A new study in The Lancet Digital Health introduces G-PROG, a deep learning model that predicts future glaucoma progression from colour fundus photographs. Read now: spkl.io/633207MUBe

Promotional card for a paper published in The Lancet Digital Health. A large letter L surrounds text that reads “G-PROG could enhance glaucoma management through improved risk stratification upon diagnosis and could hold key potential for broader applicability in predicting disease progression across various medical conditions.”

The Lancet@thelancet· 3d

Older patients represent the fastest growing patient group in clinical care. A Review discusses the critical need to improve clinical trial relevance for older patients: spkl.io/633217M135

Validity framework for research in older adults. Green represents a low risk of bias (internal validity) or high generalisability. Yellow represents some concerns with internal validity (mainly confounding bias) or generalisability. Red represents a high risk of bias (mainly confounding bias) or low generalisability. RCT=randomised controlled trial. CDR=clinical data repository. Copyright: 2026 Elsevier Ltd. All rights are reserved

The Lancet@thelancet· 3d

Ralinepag is an oral, once-daily, selective prostacyclin IP receptor agonist developed to treat pulmonary arterial hypertension (PAH). A new trial evaluated the efficacy and safety of ralinepag in patients with PAH: spkl.io/633217z4cz

Kaplan–Meier curves for time to first clinical worsening event, a composite of death from any cause; admission to hospital for worsening PAH, right heart failure, or both; initiation of parenteral or inhaled prostacyclin-pathway therapy; disease progression; or unsatisfactory long-term clinical response. The analysis used all available data, whereas the Kaplan–Meier curve is truncated at 4 years (208 weeks). Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

The Lancet@thelancet· 5d

Europe’s wildfires are a warning: climate policy is health policy. A new Lancet Editorial calls for health to be at the centre of wildfire preparedness and climate policy. Read this & more: tinyurl.com/2t2wm8ty

Cover of The Lancet's August 8, 2026 cover. Quote on cover reads: "Europe is burning."

The Lancet@thelancet· 6d

Could heart bypass surgery avoid opening the breastbone? In a new MIST trial, selected patients receiving minimally invasive coronary artery bypass grafting (CABG) reported better physical recovery at one month than those receiving sternotomy CABG. Read more: spkl.io/633297z4bN

Figure of primary endpoint and SF-36 domain scores at 1 month after surgery. SF-36 scores range from 0 to 100; higher scores indicate better health-related quality of life. Mean differences are MICS CABG minus sternotomy CABG. CABG=coronary artery bypass grafting. MICS CABG=minimally invasive cardiac surgery coronary artery bypass grafting. SF-36=36-item short form health survey. Copyright: 2026 Elsevier Ltd. All rights are reserved.

The Lancet@thelancet· 6d

Three in four eating disorder patients are not referred for specialist care, UK study suggests body weight may be a factor. Find out more in @lancetprimarycare.bsky.social: spkl.io/633267zsbC

$Research in context panel for a paper published in The Lancet Primary Care, entitled \"Weight status and pathways to eating disorder referral from primary care in England and Northern Ireland: a cross-sectional analysis of routine care data\". Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY-NC-ND 4.0.$

The Lancet@thelancet· 8d

Once rapidly fatal diseases without approved therapeutic options, systemic amyloidoses are now highly treatable. A new Review summarises treatment advancements and future directions in systemic light chain and transthyretin amyloidosis: spkl.io/633277KhbB

Human body with annotations showing potential organs or systems involved by AL or ATTR amyloidosis. Red colour indicates organs or systems mostly or uniquely involved by AL amyloidosis. Green colour indicates those mostly or uniquely involved by ATTRwt amyloidosis. Blue colour indicates sites of clinical presentation common to both. AL=light chain amyloidosis. ATTR=transthyretin amyloidosis. ATTRv=transthyretin amyloidosis variant. ATTRwt=transthyretin amyloidosis wild-type. *Also common in ATTRv. Copyright: 2026 Elsevier Ltd. All rights are reserved.

The Lancet@thelancet· 9d

The optimal duration of dual antithrombotic therapy after percutaneous coronary intervention (PCI) in patients with atrial fibrillation remains uncertain. A recent study compared the efficacy and safety of 1-month versus 12-month dual antithrombotic therapy: spkl.io/633217KhVl

Kaplan–Meier analysis of the primary efficacy and safety endpoints. (A) The incidence of the primary efficacy endpoint, defined as a composite of all-cause death or thromboembolic events (myocardial infarction, definite stent thrombosis, stroke, or systemic embolism). (B) The primary safety endpoint, defined as bleeding (International Society on Thrombosis and Haemostasis major or clinically relevant non-major bleeding). Percentages are Kaplan–Meier estimates at 12 months (day 360). Hazard ratios compare the 1-month dual therapy group with the 12-month dual therapy group and were estimated using Cox proportional-hazards models with follow-up censored at day 360. PCI=percutaneous coronary intervention. Copyright: 2026 Elsevier Ltd. All rights are reserved.

The Lancet@thelancet· 10d

"One of the biggest stories this week wasn't about a drug. It was about something far more familiar..." Lancet authors join our Editors to discuss highlights from #AAIC2026 & what excites them about the future of Alzheimer's Disease & dementia research. 🎧 Listen now: spkl.io/633277K7eS

Promotional card for The Lancet Pulse podcast. Concentric circles on a blue background.

The Lancet@thelancet· 11d

In our latest issue, the first major dementia-prevention study in Latin America finds that a structured healthy-lifestyle programme boosts memory and thinking in at-risk older adults. Find out more: spkl.io/633227K7ww #AAIC2026

Cover of The Lancet's August 1, 2026 issue. Quote on cover reads: "LatAm-FINGERS is a landmark not because it closes the dementia prevention question, but because it changes where, how, and by whom that question can now be asked and answered."

The Lancet@thelancet· 12d

Psoriasis is a common, chronic skin disease affecting more than 60 million individuals worldwide. In a new Seminar, authors provide an updated survey of current knowledge on psoriasis, its clinical management, and key future challenges: spkl.io/633247Kmmj

Figure 2: Pathophysiological features of psoriasis. (A) Characteristic
histopathological features of plaque psoriasis. Key histological features include marked epidermal thickening (acanthosis) with characteristic rounded appearance of ridges extending into the dermis (rete ridges), absent granular cell layer, and nuclear retention within the stratum corneum (parakeratosis). Diagnostic findings include neutrophilic aggregates within the stratum corneum forming Munro’s micro-abscesses. Characteristic dermal findings include dilated, tortuous capillaries within elongated dermal papillae and prominent perivascular lymphocytic infiltrates. (B) Key immunopathological cells and mediators of plaque psoriasis.

The Lancet@thelancet· 13d

Bloodstream-delivered cell therapy slows muscle decline in young people with Duchenne muscular dystrophy, phase 3 trial finds. Explore the research 👉 spkl.io/633207KSdn

$Figure: Change from baseline in musculoskeletal and cardiac endpoints up to month 12. (A) PUL2.0 total score for the ITT population. (B) PUL2.0 mid-level score for the ITT population. (C) Left ventricular ejection fraction for the ITT population. (D) Left ventricular ejection fraction for the cardiomyopathy population. Each graph shows observed mean changes from baseline at baseline, month 6, and month 12 in the deramiocel (blue) and placebo (green) with accompanying standard errors (indicated by error bars). Panels (A) and (B) show the musculoskeletal measures of PUL2.0 total and mid-level scores, respectively, in the ITT population. Both panel (A) and (B) feature dual y axes, the left showing the mean observed percentage change and the right showing the observed raw mean change on the absolute scale. Panels (C) and (D) feature observed raw mean change from baseline in left ventricular ejection fraction for the ITT population and the cardiomyopathy population, respectively.$

The Lancet@thelancet· 14d

Dual mobility versus standard cups in total hip replacement for displaced femoral neck fractures (Duality): an international, multicentre, randomised, controlled, superiority trial spkl.io/633257KRAX

$Research in context panel for a paper published in The Lancet entitled "Dual mobility versus standard cups in total hip replacement for displaced femoral neck fractures (Duality): an international, multicentre, randomised, controlled, superiority trial". Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.$

The Lancet@thelancet· 15d

More people are ageing with HIV than ever before. A new Commission in The Lancet HIV calls for HIV care that supports healthy ageing through better prevention, person-centred care, & stronger health systems: tinyurl.com/32y4yez7 #IAS2026 #AIDS2026 @iasociety.bsky.social

Lancet infographic summarising the key findings of The Lancet HIV Commission on ageing and HIV.

The Lancet@thelancet· 16d

Blood pressure and cholesterol levels in adults over 40 with obesity increasingly similar to adults with normal BMI, study suggests in The Lancet. Explore the research 👉 spkl.io/633297JLZN

Research in context panel for a paper published in The Lancet, entitled "Metabolic traits in obesity and normal BMI in industrialised countries: a multi-country analysis of national populationbased studies". Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

The Lancet@thelancet· 17d

New Review—Inherited retinal degenerations: clinical phenotypes and emerging therapies spkl.io/633297JLRh

Clinical presentation of inherited retinal degenerations. Representative visual fields (inset: green indicates intact vision; shaded regions indicate blind spots) of a simulated scene as it appears to patients, ocular fundus photos, and short-wavelength fundus autofluorescence images, of a healthy patient (left panel) compared with a patient with a rod–cone dystrophy (middle panel) and cone–rod dystrophy (right panel) indicating disease distributions that mirror the topography of the affected cell type. Copyright: 2026 Elsevier Ltd. All rights are reserved.

The Lancet@thelancet· 18d

Who owns cardiometabolic disease? Many people with interconnected conditions navigate multiple clinics and care plans. Our latest Editorial discusses whether it's time to rethink how cardiometabolic care is organised. Read more: spkl.io/633217JI79

Quote from The Lancet's July 25, 2026 Editorial. Quote reads: “Most patients do not need another appointment; they need fewer, better-owned decisions.”

The Lancet@thelancet· 18d

On the cover, a new Comment explores the intersection between climate, war, and the global health-care supply chain. Read this & more: spkl.io/633237JL1x

Cover of The Lancet's July 25, 2026 issue. Quote on cover reads: "The impacts of the current war in the Middle East and the long-term threat of climate crisis underline the acute vulnerability of health systems."

The Lancet@thelancet· 20d

🔔 Discover The Lancet Surgery & Anaesthesiology, a new journal with a sharp clinical focus, dedicated to advancing science across the full extent of #surgery, #anaesthesiology, and #perioperative specialties, across the age spectrum, and across the globe: spkl.io/633237JQbc

Illustration of a female in green scrubs, cap, and blue surgical mask, surrounded by four smaller illustrations showing surgical instruments and operating room scenes. Copyright: Grace Russell.

The Lancet@thelancet· 20d

Irritable bowel syndrome (IBS) affects 5–10% of people worldwide. A new Review discusses the current understanding of the pathophysiology of IBS in terms of peripheral, central, and integrated mechanisms. Read in @lancetgastrohep.bsky.social: tinyurl.com/5cankju9

Figure showing peripheral mechanisms contributing to IBS. This figure was created using BioRender.com. IBS=irritable bowel syndrome. Copyright: 2026 Elsevier Ltd. All rights are reserved.

The Lancet@thelancet· 20d

📣 Save the date: 18 September 2026! Join the inaugural Gustave Roussy–Lancet Lecture Series on Cancer Breakthroughs to explore personalised cancer prevention with Prof. Timothy R. Rebbeck. Join in Paris or online at 17:00 CEST. Register: spkl.io/633237yT1P

Register to attend the Gustave Roussy-Lancet Lecture Series on Sept 18. Copyright: Gustave Roussy.

The Lancet@thelancet· 21d

PMOS linked to four-fold increased risk of heart disease in women, new large US study suggests in @lancetobgyn-wh.bsky.social Read now: tinyurl.com/yvkzhej8

Research in context panel for a paper published in The Lancet Obstetrics, Gynaecology, & Women’s Health entitled "Atherosclerotic cardiovascular disease risk in polyendocrine metabolic ovarian syndrome: a nationwide, US, claimsbased, retrospective, longitudinal, cohort study". Copyright: 2026 Elsevier Ltd. All rights are reserved.

The Lancet@thelancet· 25d

Currently approved mRNA vaccines are safe and effective at preventing infectious diseases, with promise for future disease prevention and treatment, review confirms. Read more: spkl.io/633207y0ZI

Figure 1: Schematic of mRNA lipid nanoparticle components, mechanism of action, biodistribution, and expression and clearance timeline for mRNA vaccines. LNP=lipid nanoparticle. PEG=polyethylene glycol. Copyright: 2026 Elsevier Ltd. All rights reserved.

The Lancet@thelancet· 25d

Deprescribing is the process of safely discontinuing medications when they're no longer beneficial. A new Editorial discusses the complex issue of deprescribing in modern clinical practice: spkl.io/633297y0J5

Quote from The Lancet's July 18, 2026 Editorial. Quote reads: "The solution to overprescribing is not underprescribing or abruptly stopping treatment...Better care—not simply less or more—is the measure of success in medicine."

The Lancet@thelancet· 25d

More than 4 years of war have profoundly affected children's lives in Ukraine. A new World Report examines the impacts on children's health, education, & wellbeing—and the efforts to sustain essential health services during conflict. Read this & more: spkl.io/633287yLyw

Cover of The Lancet's July 18, 2026 issue. Quote on cover reads: "Every four-year-old in Ukraine has experienced nothing but war all their lives."

The Lancet@thelancet· 27d

Small island developing states (SIDS) contribute <1% of global greenhouse gas emissions, yet climate change presents a major threat to them. A new @lancetcountdown.bsky.social SIDS report in @lancetgh.bsky.social highlights the urgent need for climate-resilient health systems: tinyurl.com/4rp3u2rs

Promotional card for the 2025 small island developing states report of the Lancet Countdown on health and climate change. Writing on card reads: 3 key insights from the 2025 small island developing states report of the Lancet Countdown.

The Lancet@thelancet· 27d

What's the diagnosis? Dr Chloe Wilson, Senior Editor at The Lancet, presents the case of a 63-year-old man presenting with fever of unknown origin & masses surrounding both kidneys. Did you reach the correct diagnosis before the reveal? Read the full case: tinyurl.com/5adyvz67

The Lancet@thelancet· 27d

The early years of research and practice shape confidence, specialist interests, and professional identity—but they’re also a growing time of challenge. The Lancet Group is deepening our engagement with early-career clinicians and academics. Learn more: spkl.io/633237yguz

A group of clinical doctors discussing research data together in the hospital. Credit: Tom Werner via Getty Images.

The Lancet@thelancet· 29d

Our Clinical Resources hub is designed with clinicians in mind — clear, logical, and packed with the latest research. Discover how it can support your practice. spkl.io/633227GRy8

The Lancet@thelancet· Jul 10

The 2020 WHO–UNICEF–Lancet Commission called for children's voices at the centre of all policy. Five years on, Children in All Policies 2030 reports back: 8 lessons on what works—and what still stands in the way. spkl.io/633297HmqW