ACIR
@acir-org
Accelerating Cancer Immunotherapy Research. A free weekly digest of the latest findings in #cancer #immunotherapy. We spotlight promising research and attend major meetings. We also make cool images :)
Shen et al. developed COMPASS, an AI model that interprets pre-treatment tumor RNAseq data in the context of tumor-immune gene expression modules and maps them to predict ICB response. bit.ly/4yBe8Er
Investigating type 1 regulatory CD4+ T (Tr1) cells induced from conventional Foxp3-CD4+ T cells exposed to antigen-presenting tolerogenic DCs and IL-10, Cepika et al. used multiomic profiling and functional genomics to identify IRF4, BATF, and MAF as key transcription [...] bit.ly/4yGUVkT
Marx, Teppert, and Marisch et al. showed retinoic acid-inducible gene-I (RIG-I), the cytoplasmic sensor of short dsRNA with uncapped 5’-triphosphate (3p-RNA), was expressed in human HCC samples and induced by IFN-I on cell lines. bit.ly/4w56D6W
Using single-cell multiomics and genetic models, Song and Kharel et al. showed that, paradoxically, both sustained A2AR expression under chronic antigen exposure and hypoxia, and complete loss of A2AR drive the transition of TCFhi memory-like progenitor (Tpro) cells [...] bit.ly/4ykaG0V
Nguyen et al. used single-cell RNAseq and multiplex IHC on paired primary thyroid carcinomas and metastatic lymph nodes (LNs) to define immune determinants of nodal colonization. @cedarssinaicancer.bsky.social bit.ly/3RDaU2z
To enhance immunotherapy efficacy against escape variant clones, Ehara et al. combined MART-1 TCR-T cells with the ferroptosis inducer RSL3. IFNγ secreted by the TCR-T cells enhanced the susceptibility of melanoma cells to ferroptosis. bit.ly/44rzS81
Lelliott et al. showed that the CDK4/6 inhibitor trilaciclib enhanced the metabolic fitness of and cytotoxicity by human CD19 CAR-T cells while reducing their proliferation in vitro. @petermaccc.bsky.social bit.ly/456sQWk
Fumagalli et al. developed a focused CRISPR-knockout library targeting loss-of-function of 50 relevant genes to screen low-affinity EGFR CAR-T cells in an orthotopic human lung adenocarcinoma (A549) model. bit.ly/3T4lQXp @cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social
Abascal et al. engineered FLT3L-secreting mouse cDC1s that retained APC and phagocytic ability in vitro. bit.ly/4baBExW
In an analysis of a multi-center trial involving 628 patients with high-risk melanoma receiving adjuvant pembrolizumab, Othus et al. identified optimal time cut-points for the first infusion of 1:18 pm for recurrence-free survival and 3:48 pm for overall survival (OS). bit.ly/4vujte8
Focused on improving transplantation tolerance, Ganchiku et al. evaluated a long-lived, high-affinity receptor binding IL-2 mutein (mIL-2) in multiple solid organ transplantation models. mIL-2 therapy [...] bit.ly/3SSlhzN @harvardmed.bsky.social
Using immunopeptidomics and exome and transcriptome sequencing, Wang et al. analyzed 22 RCC samples and identified HLA-I-presented non-canonical tumor-specific antigens (TSA) derived from human endogenous retroviruses and long non-coding RNAs, with some shared across [...] bit.ly/3RprDGs
Graça et al. show that B cells are essential for CD8+ T cell effector response during chronic, but not acute, LCMV infection. bit.ly/4woD2VK
Suissa and Fidelle et al. performed targeted metabolomics to 4,336 plasma samples from 1,714 ICI-treated patients across 16 cohorts and trained an ML model that predicted 12‑month PFS, with [...] bit.ly/4gn7Kdj @gustaveroussy.fr
Using genetically engineered conditional mouse models and lentiviral-mediated somatic gene inactivation, Adler and Xu et al. developed models that allowed them to quantify immunoediting by evaluating fixed [...] bit.ly/4eTJ4qr
Rodriguez and Edinger et al. showed that pre-treatment with VLA-4-targeted, low-dose radiopharmaceutical therapy (RPT) using [67Cu] Cu-LLP2A enhanced GD2 or B7-H3 CAR T cell efficacy, resulting in significant tumor regression in xenogeneic, preclinical neuroblastoma models. bit.ly/4eREwAH
Morgand et al. performed a retrospective, longitudinal study characterizing 258 pre-malignant colorectal lesions across discovery and validation cohorts. Patients were stratified based on polyps per year. bit.ly/4bjDHj8
Lian and Nie et al. showed that LCMV gp66-specific CD4+ T cells inhibited tumor growth in an MC38-GP model in an antigen-specific manner, independent of direct lymphoid cell-mediated cytotoxicity. bit.ly/4vFbwTX
In a patient with advanced prostate cancer, pembrolizumab resulted in CR and, followed by a radical prostatectomy, prevented recurrence out to 18mo. Tumor whole-exome NGS indicated dMMR/MSI-H and an extremely high TMB. bit.ly/4fe03Fe
Shim et al. investigated how the timing of tumor antigen-specific CD8+ T cell activation shaped responses to radiopharmaceutical therapy with ⁹⁰Y-NM600 (RPT) in E.G7-OVA and TRAMP-C1 tumor models. bit.ly/3SXqlTv
Using bulk DNA/RNA sequencing and single-nucleus RNAseq, Ghannam et al. profiled 181 ICB-treated glioblastomas, benchmarking against standard-of-care cohorts, to define genomic correlates of ICB response. bit.ly/3S4Q5Nz @broadinstitute.org @danafarber.bsky.social
Caro and Kancheva et al. generated comprehensive scRNAseq atlases of tumor-associated mononuclear phagocytes (monocytes, macrophages, DCs, and pDCs) across 14 mouse and 10 human cancer settings. 31 murine and 25 human lineage-defined [...] bit.ly/4aGOLGT
In a phase 1 trial, 61 patients with advanced solid tumors were treated with a TCE comprising (1) a high-affinity TCR binder for a shared MAGE-A4/MAGE-A8 CTA peptide presented on HLA-A*02:01, (2) a humanized, low(er)-affinity anti-TCRαβ/CD3 [...] bit.ly/3QPB7KO @immatics.bsky.social
Using data from three trials of FMT plus anti-PD-1 in melanoma, Fessler et al. performed a strain-resolved metagenomic meta-analysis, and found that while neither microbial diversity nor acquisition of specific bacterial species were [...] bit.ly/4oBL8rJ @stanfordmedicine.bsky.social
To investigate immunoediting in human tumors, Borden et al. analyzed primary, treatment-naive cSCC tumors, which frequently arise in immunosuppressed patients following solid organ transplant, suggesting immune involvement. bit.ly/4xELpOI
Jassowicz, Feng, and Warta et al. used tissue cytometry, bulk and single-nucleus RNAseq, flow cytometry, and spatial transcriptomics to profile 156 human breast cancer (BC) brain metastases (BCBM) and map functionally and clinically distinct immune landscapes. bit.ly/4uDuYPJ