In this paper we disentangle the gene regulatory networks and topics that govern regeneration of neurons in larvae and adult zebrafish.🧵 2/4

Congratulations to Nikola, the first author, for his first paper 🥳 (he is the one on the left – if you want to know, why the guy on the right is also celebrating, stay tuned) 🧵 6/6

We find that the 🧬 sequence has a surprisingly large influence on replication timing, even in cell type specific loci. 🧵 4/6

In this paper we disentangle what determines the 🧬-replication timing at different loci looking at the 🧬 sequence and the epigenome.🧵 2/6

Are you looking for a new challenge? We are looking for a Deep Learning Engineer. With this role you would set up deep learning infrastructures with the goal to understand genomes 🧬 and ageing 👵 .

I am delighted, humbled, proud, and grateful to let you know that I became a professor for life today. I am very aware of the privilege that this position now brings to my life. I will do my best to pay forward the kindness and support of the people who got me here.

There is a new Master of Physics of Life in the house. Congratulations, Adnan! Well done! It was really a superb Defense! @poldresden.bsky.social

I have already been part of your movement without knowing :-)

We have a postdoc position for a project that is very analogous. The deadline has passed, but feel free to still apply, if you are interested. 🧵 6/6

In this paper we used data from patient derived organoids from adenomas of the gastroesophageal junction treated with neoadjuvant FLOT chemotherapy in the patient, or of the organoids from the untreated tumour. We reconstructed the clonal dynamics and integrated the single cell transcriptomes.🧵 2/6

We find that both the 🧬 sequence and the epigenome contribute essential information and the models perform best, when trained on both. But who contributes what? To answer this, interpretable machine learning helps and it is in the paper 😉 🧵 4/4

In this paper we disentangle what determines the genomic location of 🧬-double strand breaks looking at the 🧬 sequence and the epigenome 🧵 2/4

@helenajambor.bsky.social Making a point about the importance of data visualization. #theconferencetoendallconferences #TCTEaC

I am excited to see the first Johannstadt Campus Symposium on Computational Biology start. Looking forward to 4 exciting talks and a 🍻 hour. If you are around, please drop by.

Taking a break from 🧬 👩🏼‍💻 and went home. I’m still at the center of things, or at least, of the European Union 🇪🇺.