In their study, Carlos Sánchez-Soriano and colleagues find that one in eight mothers in England had a diagnosis of gestational diabetes between 2018-2022, and call for strategies to provide and improve care for this high risk group. https://bit.ly/45c7lne

A new study by Carlos Sánchez-Soriano and colleagues quantifies the incidence of gestational diabetes mellitus in England and examines inequalities in diagnosis and adverse pregnancy outcomes. Read now in BMJ Medicine: https://bit.ly/4z2AOhg #MaternalHealth

Delphine Mitanchez and colleagues assesses whether procalcitonin-guided decision making can safely reduce the duration of antibiotic treatment in neonatal late onset sepsis in newborns Read the full study in BMJ Medicine: https://bit.ly/3PILP5q

Explore our Methods Primers Collection, where all resources in this area are conveniently organized for your reference https://bit.ly/45vZb9G

Further imaging is indicated for biomarker scores indicating a high probability of advanced fibrosis (F3) or cirrhosis (F4), as summarised in this figure

Although not a requirement of MASLD, liver fibrosis is a crucial clinical characteristic of the severity of MASLD and spans from no fibrosis (F0), to mild fibrosis (F1), significant fibrosis (F2), advanced fibrosis (F3), and cirrhosis (F4).

Take a look at our open access specialist reviews, in one handy Collection for you to browse anytime https://bit.ly/3YpbpgB

A new systematic review by @kdsweeney.bsky.social and colleagues identifies primary care and community based interventions for patients with multimorbidity involving depression or anxiety, to determine their effectiveness for improving patients’ health https://bit.ly/3Om7OhG

Yan Xie and colleagues examine glucagon-like peptide 1 receptor agonist discontinuation and risks of major adverse cardiovascular events in adults with type 2 diabetes https://bit.ly/4cyz4CY #CardiovascularHealth

Alan Wright and colleagues find that that lowering blood pressure early in pregnancy may reduce pre-eclampsia risk by up to 50%, but a large trial is needed to confirm the benefits, risks, and costs of this for clinical practice. https://bit.ly/4srHBfI #MaternalHealth

A new study by Alan Wright and colleagues finds lowering blood pressure from early pregnancy may reduce preterm and term pre-eclampsia Read the full study in BMJ Medicine: https://bit.ly/4sfwDdh

New research by Yan Xie and colleagues found cardiovascular benefit of GLP-1RAs accumulated with continuous use, but even brief periods of discontinuations could progressively erode and ultimately reverse protection. Read the full paper in BMJ Medicine: https://bit.ly/3PpsINi

Interested in non-pharmacological interventions for fatigue in long term conditions? Joanna Leaviss and colleagues find interventions that support individuals to increase physical activity or that are based on cognitive behavioural approaches are effective in reducing fatigue https://bit.ly/47LPFAi

Immortal time can also be created due to misclassification of treatment assignment. This can arise when treatment strategies are assigned using information after the start of follow-up. In the example below early deaths (blue arrows) are misattributed to the strategy of no surgery.

Immortal time can arise due to selection bias. For example, a study compared the effect of unilateral total knee replacement (top) with staged bilateral TKR (bottom) on functional impairment. Note that more participants dropped out in the staged TKR group before eligibility criteria were applied.

In their new study, Joanna Leaviss and colleagues find that interventions focusing on physical activity and cognitive-behavioural approaches are effective in reducing fatigue in people with long-term medical conditions. Read the full study here: https://bit.ly/3PerFQ4

Sara Pretorius and colleagues review UK guidelines for individual health conditions and propose improvements to guideline development processes to improve usability of guidelines for clinicians managing patients with multiple long term conditions https://bit.ly/4slFri8

Read the full research paper in BMJ Medicine bmjmedicine.bmj.com/content/5/1/... and a linked editorial from Barbara Nichol et al bmjmedicine.bmj.com/content/5/1/...

3. This suggests that the data is not normally distributed. In this case most CAPS-5 scores were relatively low with a small number of higher score, resulting in a right skewed distribution (see image)

A new Methods Primer by Dan Green and colleagues outlines circumstances where the mean and standard deviation alone are insufficient summary variables, and provides a simple appraisal method for reviewers without raw data Read in BMJ Medicine now: https://bit.ly/4bJz3w8

New Year, New you. If your resolution involves hitting the gym, you're on the right track! Han Han and colleagues' findings support the notion that habitual engagement in a diverse range of physical activities is associated with lower mortality. https://bit.ly/4jSKy6v

🔥 The #ClimateEmergency is a health emergency too. We're calling for your #research and #editorials exploring the climate–health connection. Hear more from our EiC and get involved by browsing our latest articles https://bit.ly/48Zzuki

Similar trends were seen for systolic and diastolic blood pressure (top half of the figure, below). While the improvements in the proportion of people with controlled hypertension was also reduced in 2021 (see figure, bottom right).

The prevalence of undiagnosed hypertension in the community fell from a peak of 32.6% in 2003 (see figure, middle pane). In 2021, the only set of data since the pandemic started, the estimate had gone back up to 32.4%.

Ever wondered what it’s like to work on a medical journal? Our EiC, Sophie Cook, shares how she got started in publishing. #Publishing #EditorialRoles #CareerInPublishing

A new linked editorial by Ethan Nella and Jennifer Couturier reflects on the cohort study by Catharine Morgan and colleagues, highlighting the importance of recognising and managing risks in patients diagnosed with eating disorders https://bit.ly/4oZnwwA

How do eating disorders affect health outcomes in patients? Catharine Morgan and colleagues examine the short and long term adverse physical and mental health outcomes, all cause mortality, and deaths in individuals with a diagnosis of an eating disorder https://bit.ly/3KdOwck

However, the increased risk of dementia with use of anticholinergic bladder drugs was not seen when compared directly with use of mirabegron (incidence rate ratio 0.82, 95% CI 0.74 to 0.92).

Compared with non-use, ever use of anticholinergic bladder drugs was associated with an increased risk of dementia, with an incidence rate ratio of 1.44 (95% confidence interval (CI) 1.40 to 1.48). This risk increased with increasing cumulative drug use.

The study, by Pourhadi et al, assessed the associated risk of dementia with cumulative use of anticholinergic bladder drugs compared with both non-use and use of the β3 agonist mirabegron. They used data from Danish nationwide registries.