Channelomics
@channelomics
Our Twitter feed lives on via an IFTTT rule, but this seems a nicer place. Ion channel stuff, papers, jobs, Studentship and if you are still active at a rig; sympathy! Anyone that’s done electrophysiology knows it is the ”sharp” end of science.
Electrophysiology in nanoscale compartments rupress.org/jgp/article/... #IonChannels Interesting, but sorry $$$$$$
Evolution, hibernation, and inactivation of voltage-gated Na #ionchannels | Journal of General Physiology rupress.org/jgp/article/...
Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic #ionchannels | Journal of General Physiology rupress.org/jgp/article/...
Full article: mTORC2-Nav1.2 #ionchannel signaling drives early hyperexcitability in Alzheimer’s disease mouse model www.tandfonline.com/doi/full/10....
Gating shift to an ohmic mode of TREK-1 #ionchannel induced by docosahexaenoic acid: Biophysical Journal www.cell.com/biophysj/ful...
PIEZO #ionchannel Mechanotransduction in the Cardiovascular System: Physiological Roles and Disease Implications - Cardiovascular Science www.sciepublish.com/article/pii/...
If only there had been some clue. Editorial Note: Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium #IonChannel | PLOS One journals.plos.org/plosone/arti...
Full article: Role of TRPV4 #Ionchannels in high glucose-induced neurotoxicity in a neuronal-like cell model www.tandfonline.com/doi/full/10....
Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 #IonChannels VSDIV Journal of General Physiology $$$$$$ rupress.org/jgp/article/...
Mechanistic insights into DCPIB inhibition of VRAC anion #IonChannels: Electrostatic control and binding plasticity $$$$$$$$ rupress.org/jgp/article/...
An epilepsy-associated KV3.1 potassium #ionchannel variant acts via dominant-positive effect | Journal of General Physiology rupress.org/jgp/article/...
Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium #ionchannel | Journal of General Physiology rupress.org/jgp/article/...
Missense mutation causes multiple defects in Nav1.4 #ionchannel gating and leads to an SCN4A-associated overlap phenotype | Journal of General Physiology rupress.org/jgp/article/...
Bladder under stress: Pathological and adaptive shifts in #ionchannel expression www.tandfonline.com/doi/full/10....
Full article: Role for TREK-1 #ionchannels as a polymodal sensor and regulator of cell activity www.tandfonline.com/doi/full/10....
Full article: Quantitative analysis of trafficking defects induced by heterozygous expression of hERG #ionchannel voltage sensor domain variants www.tandfonline.com/doi/full/10....
Calmodulinopathy variants impair CaV1.3 and CaV2.1 #IonChannel regulation | Journal of General Physiology $$$$$$ rupress.org/jgp/article/...
Cav3.2 T‐type calcium #Ionchannels in chronic pain: Structural insights, pharmacological advances and challenges in subtype selectivity - Lu - British Journal of Pharmacology bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
Structural evidence that a lipid plug controls K2P6.1(TWIK-2) #IonChannel function | Nature Communications www.nature.com/articles/s41...
NMDA and glycine #IonChannel receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells - Benton - 2026 - The Journal of Physiology physoc.onlinelibrary.wiley.com/doi/10.1113/...
Functional role of Nav1.8 channels in action potentials of mouse CGRP‐lineage dorsal root ganglion neurons - Osorno - The Journal of Physiology physoc.onlinelibrary.wiley.com/doi/10.1113/...
The endogenous cannabinoid system gates plasticity of tonic GABA #IonChannel inhibition - Colangeli - 2026 - The Journal of Physiology physoc.onlinelibrary.wiley.com/doi/10.1113/...
Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue | Journal of General Physiology rupress.org/jgp/article/...
Similarity of the ion occupations of K+ and Tl+ in the selectivity filter of a K+ #IonChannel, as verified by single-channel currents. Channels. www.tandfonline.com/doi/full/10....
Full article: Cholesterol inhibits capsaicin activation of the TRPV1 channel www.tandfonline.com/doi/full/10....
Mechanistic insights into Orai #IonChannel dynamics during pore opening. Channels. www.tandfonline.com/doi/full/10....
Selective loss of Cx40 and conduction abnormalities underlie enhanced atrial fibrillation susceptibility in a HFpEF model in male mice - Kawajiri - 2026 - Physiological Reports - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.14814... #IonChannels
Temperature and intrinsic Ca2+ reshape TRPM4 #ionchannel pharmacology | Nature Structural & Molecular Biology www.nature.com/articles/s41...
Pharmaceutical agents targeting KATP #ionchannel modulate sweet taste sensitivity in mice www.sciencedirect.com/science/arti... #ionchannels
The AMPA receptor #IonChannel life cycle: assembly, regulation and synaptic diversity | Nature Reviews Neuroscience $$$$$ www.nature.com/articles/s41...