Urea vs. tolvaptan for hospitalized patients with SIADH ca. 2026 #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42455009/

Kick, Sweat, Protect: Kidney Health Through the Lens of Soccer (Football) ca. 2026 #Nephpearls #WorldCup #WorldCup2026 #NephSky 👉🏼 www.kidneymedicinejournal.org/article/S259...

Enthusiasm for EGDT has waned as 3 large, multicenter trials failed to reproduce the results of the Rivers trial #Nephpearls #AKIinICU #NephSky 🔑 Current Surviving Sepsis guidelines recommend an initial bolus of 30 mL/kg to be followed by additional fluid to maintain and improve perfusion

Obesity in CKD: Treatment algorithm ca. 2026 from @ndt-era.bsky.social @saynanorouzi.bsky.social @rahaai.bsky.social #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42446420/

The kidney in the middle: @kdigo.org guidelines address multiple key components of cardiovascular-kidney-metabolic syndrome ca. 2026 from @Kidney_Int #Nephpearls #Cardiorenal #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42191113/

When shock is refractory to initial fluid resuscitation, it is appropriate to consider vasopressor support #Nephpearls #AKIinICU #NephSky 📌 Distributive shock requires alpha-adrenergic stimulation to promote vasoconstriction and raise SVR

Screening algorithms in septic shock #Nephpearls #AKIinICU #NephSky ⚠️ SIRS may be highly sensitive but lacks specificity ⚠️ qSOFA may lack sensitivity for early sepsis or septic shock 🔑 These limitations highlight the importance of high clinical suspicion for shock 👉 shop.lww.com/Handbook-of-...

The fundamental problem in shock is "inadequate end-organ perfusion" #Nephpearls #AKIinICU #NephSky 📌 Low cardiac output (CO) ✔️ Hypovolemic ✔️ Cardiogenic ✔️ Obstructive 📌 Low systemic vascular resistance (SVR) aka Distributive: Sepsis

B cell maturation, treatment targets, and therapies ca. 2026 from @kidneyint.bsky.social @kdigo.org #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42034308/

Fabry Disease: Current Perspectives on Diagnosis and Management Strategies ca. 2026 from @akdhjournal.bsky.social @saynanorouzi.bsky.social #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42331443/

ARISE FLUIDS: Vasopressors or Fluids in Early Septic Shock ca. 2026 from @nejm.org #Nephpearls #AKIinICU #NephSky 📌 No significant difference in days alive and out of hospital at day 90 ⚠️ Pulmonary edema: Lower in restricted fluids group (0.6% vs. 5.0%) 👉 pubmed.ncbi.nlm.nih.gov/42274006/

Guideline for Prevention, Detection, Evaluation, & Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome ca. 2026 from @americanheart.bsky.social @accintouch.bsky.social @amdiabetesassn.bsky.social @asnkidney.bsky.social #Nephpearls #Cardiorenal #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42265997/

C3 glomerulopathy in transplant “like yet unlike native”: Pathophysiology, recent advances in therapeutics and evolving paradigms ca. 2026 @saynanorouzi.bsky.social #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42281853/

Mechanisms by which novel antihypertensive drug classes reduce blood pressure ca. 2025 from @natrevcardiol.nature.com #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/39920248/

Aprocitentan in Patients With CKD and Resistant Hypertension ca. 2026 #Nephpearls #NephSky ✅ Well tolerated ✅ Lowered BP (nighttime ambulatory BP) ✅ Markedly reduced urine albumin-to-creatinine ratio (UACR) in participants w/ CKD and resistant hypertension 👉 pubmed.ncbi.nlm.nih.gov/41363010/

Hemodynamic monitoring in in ICU: Capillary refill time (CRT), is quick, easily performed, and a long-standing component of the physical exam #Nephpearls #AKIinICU #NephSky 👉 pubmed.ncbi.nlm.nih.gov/30772908/ 👉 www.wolterskluwer.com/en/solutions...

FIND-CKD: Among adults with CKD who did not have diabetes, finerenone led to a slower decrease in the eGFR than placebo over 32 months ca. 2026 from @nejm.org #Nephpearls #ERA26 #NephSky 👉 www.nejm.org/doi/full/10....

Hyperkalemia and Its Treatment: Real-World Evidence and Managed Care Considerations Supporting Use of Potassium Binders ca. 2026 from @beaverspharmd.bsky.social #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42213908/

Consensus Recommendation: Real World Insights on Attitudes and Treatment of Hyperkalemia ca. 2026 from @garysinger.bsky.social @renalphysicians.bsky.social #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42069178/

Treatment of chronic hyponatremia from Dr Ewout Hoorn #Nephpearls #ERA26 #NephSky

Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial ca. 2026 from @asnpublications.bsky.social #Nephpearls #ERA26 #NephSky 👉 pubmed.ncbi.nlm.nih.gov/40913594/

Ultrafiltration and Sodium Removal in Steady Concentration Peritoneal Dialysis: A Prospective, Multicenter, Randomized, Crossover Study ca. 2026 from @asnpublications.bsky.social @wilkiemart.bsky.social #Nephpearls #ERA26 #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42240452/

C3 glomerulopathy in transplant “like yet unlike native”: Pathophysiology, recent advances in therapeutics and evolving paradigms ca. 2026 @saynanorouzi.bsky.social #Nephpearls #NephSky 👉 www.wjgnet.com/2220-3230/fu...

SAVE THE DATE for upcoming #ECNeph "Nephrotic syndrome in a patient with diabetes" 🗓️ 28th May, Thursday ⏰ 8PM IST 🇮🇳, 1030AM EST 🇺🇸, 1030PM PHT 🇵🇭 #Nephpearls #NerphSky

Glomerular frontiers: consensus perspectives from @glomcon.org @n0r0zha.bsky.social @poyanmehr.org @bettercallseeth.bsky.social @saynanorouzi.bsky.social #GlomconHawaii 🌊 2025 #NephSky #Nephpearls 👉 link.springer.com/article/10.1...

Inpatient Hypertension ? #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/38804130/ 🔳 Was the BP measured properly and accurately? 🔳 Is there evidence of acute end-organ damage? 🔳 What potential factors are contributing to the elevated BP?

Kidney disease (CKD) and heart failure (HFrEF, HFpEF): recent advances and current challenges: conclusions from @kdigo.org Controversies Conference ca. 2026 #Nephpearls #Cardiorenal #NephSky 👉 pubmed.ncbi.nlm.nih.gov/41791738/

Hypophosphatemia During Kidney Replacement Therapy and Ventilator-Free Days: A Post-Hoc Analysis of the STARRT-AKI Trial ca. 2026 @ajkd.bsky.social #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/41763519/

Hypomagnesemia and Hypermagnesemia: Treatment algorithms from @kidneyboy.bsky.social #Nephpearls #NephSky 👉 shop.lww.com/Manual-of-Ne...

Hypophosphatemia and Hyperphosphatemia: Diagnostic work up from @doctorgates.bsky.social #Nephpearls #NephSky 👉 shop.lww.com/Manual-of-Ne...