Exciting Instruments
@ei-science
Built to unlock the power of single-molecule fluorescence spectroscopy
Join Dr Stefan Mueller on 20 Aug to see how FCCS on the EI-FLEX Pro HT directly quantifies ternary complex formation, cooperativity and stability for next-generation therapeutics. Register: us06web.zoom.us/meeting/regi... #ternarycomplex #fccs #proteininteractions #drugdiscovery
📢 Today's the day! Join Tim Craggs and Prof. Taekjip Ha for this afternoon's Exciting Seminar celebrating 30 years of smFRET. Hear from the pioneer behind the first smFRET measurement and discover what's next. Register: us06web.zoom.us/meeting/regi... #biophysics #singlemoleculeFRET #virtualevent
📢 Join us on 13 July for a virtual seminar on Conformational control: From single-molecule FRET to novel biotechnologies with our CEO Tim and Prof. Taekjip Ha. 11:00am EDT | 8:00am PDT | 4:00pm BST | 5:00pm CEST Register: us06web.zoom.us/meeting/regi... #smFRET #biophysics #singlemolecule
👋 Hands up who's at #MachinesonGenes this week! Find Roman to learn how our easy-to-use tools allow you to assess the conformational dynamics and interactions of individual molecular machines. In solution, on the benchtop. Don't miss his talk on Tuesday morning (10:20 am). #smFRET #FCS
Running smFRET experiments, but unsure how to label your samples or choose the right dyes? Our technical note covers dye selection, site-specific labelling, and key design considerations to help you get reliable data. 📖 excitinginstruments.com/resource-lib... #smFRET #biophysics #biochemistry #howto
👀 Does the answer to your scientific question depend on understanding how molecules truly interact in solution? 🙌 FCS and FCCS make these measurements possible, at single-molecule sensitivity and without surface immobilisation. 📘 Learn more in our new handbook > buff.ly/CH1uUcm
🙌 Yesterday at #smbio26 was a shining example of cutting-edge single-molecule science in the UK. The team is on hand again today to discuss how our technology can help you see all the Exciting things your molecules are doing. Want a demo of our system at our nearby HQ? Just let the team know.
👀 Crystal structures don’t always reveal the full conformational landscape of proteins. Using smFRET + FCS on the EI-FLEX, Howard et al. uncovered two previously unknown salt-dependent conformational states in the bacterial helicase Rep. Read more: buff.ly/smLjyaG #smFRET #FCS #biochemistry
Who's heading to #smbio26 this week? Catch up with @timcraggs.bsky.social and @romanrenger.bsky.social to discover next-generation single-molecule fluorescence technologies that are helping researchers reveal biomolecular interactions and dynamics with exceptional sensitivity and throughput.
🤔 Is the ‘average’ molecule a liability in modern drug discovery? Bulk assays hide the transient states that decide whether biologics & TPDs succeed. Discover how smFRET, FCS & FCCS can accelerate drug discovery > buff.ly/fEfiuJM
🔎 How do antiviral therapeutics work at the molecular level Using smFRET + FCS, Groves et al. investigated how remdesivir and suramin inhibit SARS-CoV-2 RdRp, revealing distinct mechanisms of action beyond gel-based assays. 👀 excitinginstruments.com/resource-lib...
🇺🇸 Heading to the Industrial Biostructures America #ProterosIBAConference next week? Visit Jake at our booth for an intro to the EI-FLEX Pro, enabling biopharma labs to distinguish individual conformers in solution and quantify biomolecular heterogeneity with ease. #drugdiscovery #biopharma
🤔 Still wondering how smFRET works in practice - and how it complements your current techniques? Our handbook shows when and why to use it alongside existing methods to add dynamic, single-molecule insight. Download: buff.ly/CxuqL1A #smFRET #biophysics #biochemistry
👋 Run a core facility with cryo-EM or X-ray crystallography? Add smFRET/FCS to reveal dynamics, heterogeneity & interactions in solution - helping your users link structure to function with the EI-FLEX system. excitinginstruments.com/ei-flex/?utm... #biophysics #biochemistry #corefacility
Find Tim and Charlotte at today's #LondonPolymerGroup meeting (at @imperialcollegeldn.bsky.social) to learn how single-molecule data can complement your existing workflows to reveal polydispersity and #polymer conformational dynamics, and confirm nanoparticle cargo loading or leakage in real-time.
🤔 How do #proteins reshape RNA dynamics? Static structures tell only half the story. Using smFRET on the EI-FLEX, the @chillzaa.bsky.social lab at @yorkuniversity.bsky.social mapped viral protein–dependent RNA pseudoknot formation - revealing it as a binary, protein-triggered event > buff.ly/IVQYK72
👀 Your #molecules are doing something exciting! But what, exactly? Discover - when and why - #smFRET is the method of choice to use alongside your current techniques, adding a layer of dynamic data that can quantify #biomolecularconformations and complex formation. Learn more > buff.ly/arAGYZ4
🙌 Congratulations to Chadda et al. on their new paper! #smFRET on the EI-FLEX provided a highly complementary technique alongside SEC, mass spectrometry, mass photometry & bulk FRET to elucidate the pathway that forms mature intasomes from viral #DNA & retrovirus integrase dimers.👀 > buff.ly/mkBUmjc
👀 In our new application note, we demonstrate how fluorescence cross-correlation spectroscopy (FCCS) can be performed on the EI-FLEX system to characterise the formation of a ternary complex > excitinginstruments.com/resource-lib... #ternarycomplex #fccs #PROTACs #molecularglues
Who's heading to the #ClimbTour #Sheffield edition tomorrow? Our very own @timcraggs.bsky.social will be joining a great lineup of founders, investors, and ecosystem leaders, coming together for an afternoon of insights and networking. Hope to see you there 🙌 #entrepreneurs #innovation #climbuk
Check out our Novalix conference poster below, with a focus on true #ternarycomplex formation and cooperativity, and how the EI-FLEX Pro supports dynamic #proteincharacterisation in #induced-proximity #drugdiscovery. Email info@excitinginstruments.com to discuss the poster in more detail.
🔍 Want to know whether your biomolecules form static, heterogeneous populations or are dynamically interconverting? Our latest appnote highlights how the EI-FLEX system can recover rates of molecular #conformationaldynamics, using #DNA hairpins as a well-characterised test system > buff.ly/zRH2KmM
Want to add easy access to #smFRET, #FCS and #FCCS to your core facility? Our new tools for single-molecule measurements offer: 💪 Reliable performance ⚡ Intuitive workflows 🦶 Small footprint, big impact Learn more and get in touch > buff.ly/q8KQw0i #corefacilities #biophysics #singlemolecule
👀 At #BPS but haven’t stopped by booth 401 yet? Meet the team to discover how you can unlock the ultimate #single-molecule resolution at your benchtop, generating high-impact insights into #biomolecular interactions and dynamics. See you there! @biophysicalsoc.bsky.social #biophysics #lifescience
At the final day of the @novalix.bsky.social conference? If you haven't had chance to meet with Audrey and Jake yet, there's still time to discuss how confocal fluorescence spectroscopy can accelerate your induced-proximity drug screening ⚡ #ternarycomplex #molecularglues #PROTACs #novalix