Aflah Hanafiah, Zhonghua Gao et al show that cPRC1.2 complex forms #chromatin loops at poised bivalent promoters. A switch from cPRC1.2-mediated to CTCF-mediated active loops enables differentiation to #neuronal progenitors and activation of lineage-specific genes. link.springer.com/article/10.1...

“… the most impactful publications in modern science are increasingly not primary theoretical or experimental findings, but the methodological innovations that enable and support them.” Read the full Science & Society article by Krauss, Rosenfeld & Bornmann -> link.springer.com/article/10.1...

The second July issue is online: link.springer.com/journal/4431... The cover features work by Naoyuki Inagaki, Kio Yagami and colleagues from NAIST describing spontaneous membrane protrusion and cell morphogenesis via self-propelled #actin filaments. -> link.springer.com/article/10.1...

A new review is online! Monja Müller, Konstanze Winklhofer @ruhr-uni-bochum.de and Fulvio Reggiori discuss the role of E3 #ubiquitin ligases in selective types of #autophagy. -> link.springer.com/article/10.1...

A new review is online! Umut Sahin and Elif Nur Firat-Karalar @cytolabkoc.bsky.social describe the role and alterations of the #centrosome - #cilium - satellite axis in neurodegenerative disease and discuss potential mechanism-based therapeutic strategies. -> link.springer.com/article/10.1...

Francesca Pappacena, Jean-Michel Cioni and co-workers show that lc3b mRNA is translated on #endosomes in #axons and that this local synthesis is vital for clearance of dysfunctional endosomes by #autophagy. #ProteinSynthesis #neurons -> link.springer.com/article/10.1...

Yanis Macé, Nicolas Bidère and co-workers show that CYLD is a target of #caspase -3. CASP3-induced cleavage of CYLD tempers inflammatory signaling and heps maintain #apoptosis silence. #inflammation #CellDeath #ubiquitin -> link.springer.com/article/10.1...

The first July issue is online: link.springer.com/journal/4431... The cover features work by Hsiao-Ying Kuo from NYCU Taipei describing activity-dependent #development of #vocal circuits in the neonatal rodent #forebrain. -> link.springer.com/article/10.1...

Philippe Dehio @pdehio.bsky.social, Christoph Hess and co-authors describe a conserved VPS34-PIKfyve pathway regulating #T cell and amoeboid cell migration speed via #lysosome Ca2+ efflux, #myosin IIA activation and retrograde #actin flow. -> link.springer.com/article/10.1...

Mindong Ren, Michael Schlame and co-authors show that cardiolipin de novo synthesis, but not remodeling, is essential for mouse postnatal maturation of cardiac mitochondria, respiratory chain biogenesis and cardiac function. #lipid #mitochondria -> link.springer.com/article/10.1...

Gayatri Rai, Bama Charan Mondal and co-authors show that the COP9 signalosome and Cullin-RING #ubiquitin ligases regulate the cell fate of myeloid-type blood progenitors in Drosophila via EGF and #WNT #singaling. -> link.springer.com/article/10.1...

Timo-Daniel Voss @unihohenheim.bsky.social and co-authors show that C-terminal lysine residues localise NLRP10 at lipid droplets and govern #NLRP10 oligomer formation. link.springer.com/article/10.1... Press releases: www.uni-hohenheim.de/index.php?id... idw-online.de/de/news873496

Schistosomiasis affects 110 million African children. Its control demands an urgent shift from drug treatments to permanent transmission interruption. Read the article by Francisca Mutapi and Mark EJ Woolhouse here: -> link.springer.com/article/10.1...

Margot Sahnine, Dorian Obino and co-workers @pasteur.fr show that N. meningitidis induces membrane protrusions with distinct #F-actin networks in epithelial and endothelial cells. The branched network in endothelia depends on Arf1. #Host-pathogen #membrane -> link.springer.com/article/10.1...

Naoyuki Inagaki at Nara Institute of Science and Technology (NAIST) and co-workers show spontaneous #membrane protrusion and cell morphogenesis happens via self-propelled #actin filaments. link.springer.com/article/10.1... Read the press release here: www.naist.jp/en/research_...

See our second June issue! link.springer.com/journal/4431... The cover features work by Xin Zhang, Xiaozhi Rong, Jianfeng Zhou and co-workers showing that CST complex subunit Stn1 amplifies #Wnt/beta-catenin signaling and ensures proper #oocyte development. -> link.springer.com/article/10.1...

A new review is online! Wassim Daher, Laurent Kremer and co-authors @umontpellier.bsky.social @inserm.fr @irim-life.bsky.social tell you all you need to know about organelle interplay in host responses and #mycobacterial #resilience. -> link.springer.com/article/10.1...

See our first June issue! link.springer.com/journal/4431... The cover features work by Daniel Ríos @yosoyden.bsky.social at UNAM in Mexico City and co-workers showing that the #ECM scaffolds interdependent #tissue morphogenesis in #Drosophila. link.springer.com/article/10.1...

Congratulations to Mayra Aguirre-Garcia from Annemarie Meijers lab @unileiden.bsky.social for receiving the EMBO reports poster prize at #EMBOpathogenSignalling for her work "GBP1 recruitment to Mycobacteria-containing vesicles through calcium signalling drives #macrophage lysosomal defenses".

Attending the GRC conference “Endosomes and Lysosomes in Action Across Cells, Tissues and Disease States” in Andover, NH? www.grc.org/lysosomes-an... Talk to our editor Martina Rembold who is attending the meeting about your work or publishing-related topics! #lysosome #endosome

Great EMBO YIP @embo.org lecture by Teresa Thurston @thurstonlab.bsky.social @ox.ac.uk at "Pathogen Immunity and Signalling" #EMBOpathogenSignalling. Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs. See also: -> link.springer.com/article/10.1...

Attending the EMBO @embo.org workshop "Pathogen Immunity and Signalling" #EMBOpathogenSignalling in Leiden? meetings.embo.org/event/26-pat... Talk to our editor Achim Breiling who is attending the meeting about you work or publishing-related topics!

A tumour-host feed-forward loop contributes to the growth of chromosomal instability-induced tumours. -> link.springer.com/article/10.1...

The end of a great meeting: Gemma Crupi @magnanilab.bsky.social @icr.ac.uk won the EMBO reports poster prize at #embocancerevolution in Rimini. -> meetings.embo.org/event/26-can... Congratulations!

Second May issue is live! link.springer.com/journal/4431... The cover features work by Mateusz Majda @matmajda.bsky.social and Richard S Smith @johninnescentre.bsky.social showing that puzzle cells transform cell geometry into a living record of how leaves grow. link.springer.com/article/10.1...

Hi #EMBOCancerEvolution! Talk to our editor Achim Breiling who is attending the meeting about you work or publishing-related topics!

Kosuke Miyauchi at Center for Integrative Medical Sciences @riken-science.bsky.social and co-workers show that TMPRSS2-induced #Golgi disruption restricts the incorporation of #virus envelope glycoproteins into #virions. -> link.springer.com/article/10.1...

A new review is online! Cynthia Reinhart-King and co-authors tell you all you need to know on cellular mechanometabolism: stimuli and implications. -> link.springer.com/article/10.1...

First May issue is live: link.springer.com/journal/4431... Cover features Simon Unterholzner @simonjunterholzner.bsky.social @unibz.bsky.social and co-workers showing that #brassinosteroids control cell proliferation in the lateral #root cap of #Arabidopsis. -> link.springer.com/article/10.1...

The Hippo paradox! Takahiro Chihara and co-workers show that the #Hippo tumor suppressor pathway triggers non-cell autonomous #tumorigenesis in #Drosophila. link.springer.com/article/10.1... Highlighted by Pooja Rai & Andreas Bergmann: link.springer.com/article/10.1...