𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Sex-linked helicases DDX3X and DDX3Y regulate G-quadruplex-associated stress in neurons With @mcgovernpeds.bsky.social @uthealthhouston.bsky.social In Cell Death Dis. @springernature.com 👉 doi.org/10.1038/s414...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Discriminating G-quadruplex topologies by bright-field microscopy With Nanjing U., PRC and @polytechniqueparis.bsky.social In @sciencechinapress.bsky.social @springernature.com 👉 doi.org/10.1007/s114...

The first-ever ISI Scientific Day! So great to have all these talented people together for an inspiring meeting 👍

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC With @ucllifesciences.bsky.social & @westernu.ca Now in Genome Biol. @springernature.com 👉 doi.org/10.1186/s130...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Modulating PhpC bioavailability and cellular activity in lung cancer cells via gold nanoparticle functionalization With @ubeirainterior.bsky.social and @westernu.ca Now in JDDST @elsevierlsj.bsky.social 👉 doi.org/10.1016/j.jd...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Deep learning framework integrating 18F-FDG PET/CT and clinical data for early prediction of chemotherapy response in advanced breast cancer @elsevierconnect.bsky.social 100% ICMUB @cnrs.fr 👉 doi.org/10.1016/j.bs...

The molecular helicase PhpC developed by ISI's researchers to unfold G-quadruplex #G4 DNA and RNA is now commercially available at Idylle @idylle-labs.bsky.social 👉 shorturl.at/efE5l Its ability to unfold G4s in human cells was just thoroughly described in this preprint 👉 doi.org/10.64898/202...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences In @narjournal.bsky.social With Nanjing Univ. and @polytechniqueparis.bsky.social @cnrs.fr doi.org/10.1093/nar/...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Convergent Synthesis of Template-Assembled Synthetic G-Quartets (TASQs) Used as Biomimetic and Multivalent G-Quadruplex (G4) Ligands 100% ICMUB! @cnrs.fr 👉 doi.org/10.1002/chem...