Among patients hospitalized with #HeartFailure, both a small left ventricle and a large left ventricle were associated with higher all-cause mortality vs normal size, showing a U-shaped association between left ventricular end-diastolic diameter and risk. ja.ma/4z6kE6v

From JAMA: Among patients undergoing elective cardiac surgery, perioperative #dapagliflozin reduced postoperative #AcuteKidneyInjury compared with placebo over 7 days. ja.ma/4wnKyA9

📑 JAMA Cardiology Patient Page: New fatigue, shortness of breath, chest discomfort, dizziness, or leg swelling during or after #BreastCancer treatment may signal #HeartDisease and warrant prompt evaluation. ja.ma/4yLpMwu

In patients with #TransthyretinAmyloidCardiomyopathy, acoramidis improved #HeartFailure-related health status vs placebo, with a 9.9-point benefit in Kansas City Cardiomyopathy Questionnaire Overall Summary score at 30 months. ja.ma/3U3v6eF

Among asymptomatic patients with #MitralRegurgitation managed medically, 5-year survival declined from 88% with effective regurgitant orifice area <20 mm2 to 72% with 20-39 mm2 and 55% with >40 mm2. ja.ma/44YzOwH

💬 Viewpoint: #CardioOncology needs to move beyond consensus-driven surveillance toward prospective trials, risk stratification, and clinically meaningful cardiovascular end points in patients with #Cancer. ja.ma/3S1I8J9

📝 JAMA Cardiology Review: Interatrial dyssynchrony from disease or conventional pacing delays left atrial activation and may raise arrhythmia risk; optimized pacing strategies are an active area of research. ja.ma/4puAkf8

Among adults with asymptomatic severe #AorticStenosis, 15% had a positive treadmill stress test, but 20% of these patients remained untreated at 1 year despite AVR indications. ja.ma/4ffwC5J

A digitally enabled quality improvement strategy modestly improved #LDL_C control and increased prescription of combination lipid-lowering therapy for patients with #ASCVD, but many remained above guideline targets. ja.ma/4yxMEiP

The LDL-C–MH-MARS machine learning equation matched the Martin-Hopkins equation for #LDL_C accuracy and outperformed Friedewald, Sampson-NIH, and Modified Sampson equations in nearly 5 million US patients. ja.ma/4hee7Qq

💬 Editorial: Slowed declines in US #IHD mortality are linked to rising obesity and glucose intolerance, contributing to lower life expectancy and healthy years compared with other high-income countries. ja.ma/4wOnawg

In 2023, nearly 89% of #IHD deaths in the US were attributable to modifiable risks, with high blood pressure, diet, and high low-density lipoprotein cholesterol as the top contributors. ja.ma/3TAW794

Maternal diabetes during pregnancy was associated with increased risk of overall #CardiovascularDisease and specific CVD subtypes in offspring, with congenital heart disease, preterm birth, and large for gestational age mediating part of the association. ja.ma/3SXNAgj

In patients with heart failure with mildly reduced or preserved ejection fraction, finerenone consistently lowered systolic blood pressure and reduced cardiovascular deaths and heart failure events, independent of baseline blood pressure. ja.ma/4aGWWD8

Heat-attributable #CardiovascularDisease burden in the US may triple by 2050, with population aging and income disparities amplifying risk, highlighting the need for targeted heat mitigation in vulnerable communities. ja.ma/4eUTCH7

In patients with obstructive #hypertrophic #cardiomyopathy, aficamten improved exercise measures, including peak oxygen uptake and recovery, compared to metoprolol, supporting its use as first-line therapy for symptomatic oHCM. ja.ma/4vR2IdX

📝 Case Report: Dual-phase computed tomography demonstrated acute #cardiac tamponade developing within seconds in a hemodynamically stable patient with type A #aortic dissection, highlighting the need for immediate surgical readiness. ja.ma/4gvxGDM

Among adults with Friedreich ataxia #cardiomyopathy, intravenous AAVrh.10hFXN gene therapy was well tolerated and associated with increased #cardiac frataxin, reduced left ventricular mass index, and lower serum troponin I. ja.ma/4ycL99J

Hospital adoption of the #Resuscitation Quality Improvement program was not associated with improved #survival to discharge or return of spontaneous #circulation for in-hospital #cardiac arrest. ja.ma/4vmoRzK

Following price reductions for #PCSK9 inhibitors, spending per prescription under Medicare Part D declined, but overall utilization and total program spending increased as more beneficiaries initiated therapy. ja.ma/4asfEye

This case report discusses a rare complication in a female patient in her 40s with cardiac sarcoidosis who underwent repeated ventricular tachycardia ablations. ja.ma/4vae3ET

This case report discusses a rare cause of cardiac tamponade in a male patient aged 52 years who presented with progressive dyspnea, chest pain, and palpitations over 3 months. ja.ma/44AOUbp

💬 Editorial: Projected increases in ambient heat and demographic aging are poised to escalate US #CardiovascularDisease burden, with greatest impact in economically vulnerable and under-adapted regions. ja.ma/4ph7q2l

This case report discusses a case of nonbacterial thrombotic endocarditis in an adult male with non–small cell lung cancer. ja.ma/4eLw5XR

Abbreviated #DAPT (1–3 months) after #PCI in #HighBleedingRisk patients reduced bleeding risk without increasing major adverse cardiovascular events compared to standard 6–12-month regimens. ja.ma/4f3wCpa

In emergency department patients with suspected #AcuteCoronarySyndrome, a sixth-generation high-sensitivity cardiac troponin T assay identified twice as many low-risk patients for myocardial infarction at presentation compared with the current assay. ja.ma/3QDtiIc

💬 Editorial: Prasugrel demonstrated superior efficacy and safety vs clopidogrel and ticagrelor after #PCI for #AcuteCoronarySyndrome, but P2Y12 inhibitor choice must be individualized for patient-specific factors. ja.ma/44rupOe

Increased #Lp(a) levels were associated with higher risk of #CoronaryArteryDisease, but only #IL6 modified Lp(a)-associated CAD risk among UK Biobank participants. ja.ma/4oMgjAB

💬 Editorial: At 7 years, #TAVR and #SAVR showed similar rates of structural valve deterioration and failure for low-risk #AorticStenosis, with small annulus predicting higher risk. #NYValves2026

Small aortic annulus increased risk of structural valve degeneration and failure after #TAVR or #SAVR, supporting careful anatomical assessment in long-term management of #AorticStenosis. #NYValves2026