New interim analysis data demonstrate an association between reductions in visceral fat area (VFA) and improved treatment response in patients undergoing fertility-sparing therapy for endometrial cancer (EC) or atypical endometrial hyperplasia (AEH). 🔗 doi.org/10.1530/JOE-25-0205

New special collection provides a dedicated platform for research that advances understanding of the fundamental endocrine & molecular mechanisms through which endocrine diseases affect skeletal muscle metabolism. 🔗 journals.bioscientifica.com/joe/pages/skeletal-muscle-in-endocrinology-metabolism

Research by Micaela Inés Llanos Dumont et al. reveals steroid-dependent plasticity of hypothalamic astrocytes, supporting a key role for astrocyte–GnRH neuron interactions in the regulation of reproductive neuroendocrine function during gestation in plains vizcacha. 🔗 doi.org/10.1530/JOE-26-0001

🌐 We're proud to publish research that helps drive progress. Its influence is reflected in advances to endocrinology & strong research community engagement, reflected in our increased 2025 Impact Factor & continued CiteScore growth. 🔗 journals.bioscientifica.com/joe/pages/highly-cited-collection

Exceptional visual contributions enhance research impact. At Journal of Endocrinology, we recognise such contributions through our Editors’ Choice Award. This quarter’s winner is Figure 3 in 'Bile acid metabolism: a potential node in the pathogenic network of PCOS' 🔗 doi.org/10.1530/JOE-25-0225

We're delighted to recognise this quarter's Editors' Choice Award Winner: 'Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity' doi.org/10.1530/JOE-25-0391 Thanks to the authors for their contribution to endocrinology! 👏

New research by Chanisa Thonusin et al. explored the effects of the probiotic Lactobacillus reuteri KUB-AC5 on cardiac mitochondria in obesity, demostrating improvements in cardiac function and restored antioxidative capacity of cardiac mitochondria. 🔗 Read the research: doi.org/10.1530/JOE-...

New research by Dana María Negretti-Borga et al. suggests that the immunostimulatory effects of triiodothyronine (T3) on dendritic cells (DCs), and the driven adaptive immunity, are modulated by a complex sphingolipid-mediated signaling network. 🔗 Read the research: doi.org/10.1530/JOE-26-0081

New research by Zicheng Wang et al. demonstrates that downregulation of the solute carrier family 32 member 1 (SLC32A1), a GABA transporter protein, mediated PAI-1 pathway attenuates hepatic stellate cell activation and liver fibrosis. 🔗 Read the article: doi.org/10.1530/JOE-25-0300

New research by Yiwen Jiang et al. investigates the role of brain-derived membrane-initiated estrogen receptor-α (mERα) signalling in bone metabolism using a POMC-C451Af/f mouse model, in which mERα signalling is selectively inactivated in POMC-expressing neurons. 🔗 doi.org/10.1530/JOE-...

🧬 How does CXCL13 contribute to obesity-related multi-organ complications? A new review by Mengke Huang et al. elucidates the pivotal role of C‑X‑C motif chemokine ligand 13 (CXCL13) in obesity-associated metabolic inflammation. Read the article #openaccess: doi.org/10.1530/JOE-25-0295

A new study by Kuan-Chan Chen et al. provides insight into the physiological function and role of bone marrow adipose tissue (BMAT) in caloric restriction (CR)–associated skeletal and metabolic health. 🔗 doi.org/10.1530/JOE-...

A new hot-topic review by Melissa Emily Wright, Aled Rees, and Kevin Murphy discusses how advanced neuroimaging applications could provide new insights into the pathophysiology of polycystic ovary syndrome (PCOS; recently renamed to PMOS). 🔗Read the review: doi.org/10.1530/JOE-...

New research by Amelia R Tanner (cupediatrics.bsky.social) et al. investigated the effects of 9 days of glucagon infusion (5 or 50 ng/kg/min) in late-gestation fetal sheep, increasing plasma glucagon concentrations by ~800% to study chronic fetal hyperglucagonemia. 🔗 doi.org/10.1530/JOE-25-0447

🎉 Announcing the winner of the 2025 Best Paper Award 🎉 The 2025 Best Paper Award is presented to Désirée R Seib, Minseon M Jung, and Kiran K Soma for their paper: “Maternal sucrose consumption alters steroid levels in the mother, placenta and fetus” Huge congratulations to the authors!

We celebrate impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award. The Q1 winner is Figure 3 in 'Clocks on steroids: how glucocorticoid receptors tell cells the time' By Anna Edmondson et al. 🔗 doi.org/10.1530/JOE-25-0340 Congratulations to the authors!

🏆 We're thrilled to award the Q1 Editors' Choice Award to: Fat’s all, folks: culturing and manipulating peri-prostatic adipocytes to probe impacts on prostate cancer biology By Nil Grunberg et al. 🔗 doi.org/10.1530/JOE-25-0256 Thanks to the authors for your outstanding contribution 👏

New research by Qiong Wu et al. identifies numerous dysregulated lncRNAs through microarray analysis of human preadipocytes and differentiated adipocytes, with a focus on lncRNA521141 as a regulator of adipogenic differentiation. Read the research: doi.org/10.1530/JOE-...

⏰ Glucocorticoids synchronise cellular circadian rhythms via canonical and rapid non‑canonical GR signalling, but the exact mechanism remains unclear. This review outlines current knowledge, key gaps, and how disrupted GC rhythms contribute to circadian‑linked disease. doi.org/10.1530/JOE-25-0340

A new study by Jinyuan Zhang et al. examines how TFF3 regulates lipotoxicity in male DKD mouse models. By investigating its effects on the AMPK/ACC & SCAP/SREBP signalling pathways, the study sheds light on the molecular mechanisms linking TFF3 to DKD progression. 🔗 doi.org/10.1530/JOE-25-0303

Tmem119 has been shown to participate in the bone anabolic effects of PTH through the stimulation of osteoblastic bone formation in mice. A new study investigates Tmem119's role in PTH-enhanced bone repair after a femoral bone defect using Tmem119-deficient mice. 🔗 doi.org/10.1530/JOE-25-0375

miR-200b-3p is linked to obesity, but understanding of its role in the pathogenesis of obesity remains limited. New research by Lang Qin et al. suggests that miR-200b-3p regulates adipocyte browning by targeting Prdm16 & could serve as a therapeutic target. 🔗 doi.org/10.1530/JOE-25-0131

🔎 A new study by Shinichiro Toyoda et al. examines how clinical hypoglycemia phenotypes may relate to the immunohistochemical expression of glucose transporters (GLUTs), glucokinase (GCK), and the glucagon‑like peptide‑1 receptor (GLP-1R) in insulinoma cells. 🔗 doi.org/10.1530/JOE-25-0134

New study compares two major mouse models of estrogen loss - AROM KO (congenital) and OVX (adult‑onset). It highlights shared & distinct E2‑deficient traits, helping researchers choose the right model & offering a rich dataset for studying the effects of estrogen decline. 📄 doi.org/10.1530/JOE-...

Triac is a thyroid hormone metabolite, with thyromimetic properties, present in sewage treatment plant effluents. New findings by Quinte F Geessinck raise an important question, could Triac act as an environmental endocrine disruptor? 📖 Read the research: doi.org/10.1530/JOE-25-0480

A new multi‑cohort analysis investigates how disrupted iron homeostasis & alterations in iron metabolism may link alcohol intake to hepatic injury. The study provides novel evidence that pure alcohol intake is significantly associated with liver steatosis and fibrosis. 🔗 doi.org/10.1530/JOE-25-0293

A new study focuses on how the duration of PCOS influences hormonal profiles, bone metabolism, and bone’s microstructural and mechanical properties in the PCOS-induced mice model, providing insight into how the condition may alter skeletal integrity. Read the research: doi.org/10.1530/JOE-25-0292

Recent research by Yuehui Zhang et al. identifies mitochondrial AR in the uterus and demonstrates that hyperandrogenism-induced, AR-dependent mitochondrial dysfunction in decidual stromal cells is a key mechanism underlying pregnancy loss in PCOS. Read the full study: doi.org/10.1530/JOE-...

A new study by Nil Grunberg et al. outlines a protocol for ex vivo culture of fresh peri-prostatic adipose tissue (PPAT) and non-prostatic adipose tissue (NPAT), which reflects donor- and depot-specific characteristics. 🔓 doi.org/10.1530/JOE-25-0256

Can leonurine, an alkaloid known for its anti-inflammatory & antioxidant properties, be effective in treating lung ischemia-reperfusion injury? New research by Wanying Chen et al. explores the therapeutic potential of LEO in a murine model. 🔓 Read the full article: doi.org/10.1530/JOE-25-0298