🧪We report new small molecules targeting #TSG101 in the #ESCRT pathway and interfering with the replication/egress of multiple viruses of major biomedical concern: #Ebola, #Marburg, and #Nipah viruses, as well as #EVD68. A promising strategy to develop broad-spectrum antivirals. lnkd.in/dS3mC42Q

🧪Chlorinated #carbazoles showed promising activity against Gram-positive/negative #/bacteria and #MDR #Clinical #isolates with no apparent cross-resistance. The study also points toward membrane disruption as a relevant mechanism of action. Open Access here: lnkd.in/dY2qQYKd

🧪Here we show the efficacy and safety of #proprietary 3-cyanoquinoline derivatives (WO 2026/017799) as topical #microbicides with broad-spectrum activity against both sexually transmitted #viruses and #bacteria, including MPXV, HSV-1/2, HIV, HCV, and Chlamydia trachomatis. lnkd.in/d2cGaFqT

🧪Is there still space today to conduct #drugdiscovery without relying on AI-driven tools? We describe the integration of functional assays, #greenchemistry and late-stage functionalization to develop metabolically stable #PCSK9 modulators. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

🧪 The registration deadline for the First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy, has been extended! Here: lnkd.in/d6dnB8cc Don’t miss the opportunity to share your work, connect with peers, and showcase your research in a high-impact venue.

🧪 We are delighted to present this #Wiley #Special #Collection inspired by two #international #conferences which debuted this year: 📍The First International Conference on Anti-Infectives 2025 in Saarbrücken, Germany 📍The First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy

🧪Complex diseases don’t work like broken clock that can be fixed by replacing a single part As an alternative to the reductionist approach, we present a #multitarget #polypharmacological strategy to reduce drug #burden & prevent pulmonary #exacerbations in #CF www.sciencedirect.com/science/arti...

🧪 In this work, we challenged ourselves to look beyond conventional #Antiviral #Drug #Discovery approaches, exploring an #evolution-#inspired strategy rooted in #prebiotic #chemistry. It’s been an exciting journey of creativity, curiosity, and collaboration. www.nature.com/articles/s41...

🧪This event, held in Catanzaro (Italy) on September 30 2025, will be focused on innovative #antiviral #DrugDiscovery #strategies. To view the full program, register and submit an abstract, visit: 👉 lnkd.in/d6dnB8cc 📅 Registration deadline: July 25, 2025 📧 For further information: panviride@gmail.com

This is one of the reasons why #peer #review for Scientific Journals should not be treated as an unpaid service, but rather recognized and compensated as a highly professional fee-based activity.

Best thing I did so far....

🧪Have you ever wondered whether targeting #PI4KB and #Src / #Abl host kinases could be the next big thing in broad-spectrum #antiviral strategies? 🧐 Well, so did we! But instead of just wondering, we dug deep into the literature and wrote a whole review about it www.sciencedirect.com/science/arti...

The Radi Lab 🧪 goes on vacation! 🎄🎉

Saturday night fever...🕺

I'm so proud of this paper and its cover that I just can’t leave it sitting on the other side...😉 #Electrochemistry & #Multicomponent Late-Stage Functionalization ( #LSF) of anti- #PCSK9 drug candidates. 🧪 #GreenChemistry pubs.rsc.org/en/content/a...

As inaugural post, I want to present our #PANVIRIDE network. We are developing new Broad-Spectrum #Antivirals and happy to expand our collaborations. 🧪