Mike Inouye
@mikeinouye
Computational biologist. Geriatric Millennial. Professor, University of Cambridge. Director of Data Sciences, Baker Heart & Diabetes Institute. British | Australian | American. www.inouyelab.org | Cambridge, UK
Latest from our lab! A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestries www.medrxiv.org/content/10.6... A truly global collaboration of computational and experimental researchers. h\t @yuxu.bsky.social, Doug Loesch, Henry Taylor among many!
Important commentary from @thisinstitute.cam.ac.uk (Niels Peek, @marydixonwoods.bsky.social and co) on building the evidence base for how AI *might* help the NHS www.bmj.com/content/394/...
Nearly 15 years since starting a group, I've tried to encapsulate our research in a set of publications that best represent the group's 3 major programmes: - Next-generation prediction of disease - Uncovering aetiology through multi-omics - Open and sustainable computational methods and resources
Bacterial diversity and strain dynamics in the infant respiratory microbiome during the first year of life www.biorxiv.org/content/10.6... Cool study led by @gmeric.bsky.social @katholt.bsky.social @gazollavolpiano.bsky.social!
Haven't seen any health economic modelling of PRS for primordial prevention (i.e. intervention in early life / childhood) before... but just came across this interesting study: www.nature.com/articles/s44...
Super chuffed to see our latest preprint is out: Polygenic risk of cardiovascular disease manifests in cardiac structure and function 👉 www.medrxiv.org/content/10.6... A collaborative study led by exceptional PhD student Benedetta Felici!
Contextualizing the Utility of Polygenic Risk Scores using Absolute Risk Models in Diverse Ancestry Populations www.medrxiv.org/content/10.6... I don't think Nilanjan is on bluesky so cross-posting his preprint (and linkedin summary) here: www.linkedin.com/posts/nilanj...
Wonderful to see the new integrated OmicsPred resource now preprinted at medrxiv: "OmicsPred as a centralised resource for genetic prediction of multi-omic traits" www.medrxiv.org/content/10.6... OmicsPred: www.omicspred.org
📣 New preprint: Plasma proteomics improves prediction of recurrent cardiovascular events www.medrxiv.org/content/10.6... Wonderful work with Yang Liu, @sritchie73.bsky.social, and many at @cambridge-ceu.bsky.social
Important work for stratifying risk of heart failure in Europe. Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model academic.oup.com/eurheartj/ad...
Today is the National Day of Remembrance for US Executive Order 9066. EO9066 illegally confiscated the property and possessions of all Japanese Americans, including my grandparents and other US citizens. It forced them into remote concentration camps for years.
A large language model for complex cardiology care www.nature.com/articles/s41...
Throughout the 1940-70s lead exposure was a public health catastrophe... and then people got serious about environmental intervention "Lead in archived hair documents a decline in lead exposure to humans since the establishment of the US Environmental Protection Agency" www.pnas.org/doi/10.1073/...
This was posted on bsky a few days ago, cant recall where. But it’s really quite good. www.volts.wtf/p/the-cure-f... How are peoples’ minds really changed? It’s rarely rational or evidence based, it’s down to their (social) identity.
Individuals whose phenotype deviates from genetic expectation defined by common variation are enriched for rare damaging variants in genes that cause rare disease www.medrxiv.org/content/10.6...
Just published @ Eur Heart J: Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction academic.oup.com/eurheartj/ad... tl;dr these next-gen risk factors could boost the number of CVD events prevented by +80% while keeping treatment efficiency (NNT) the same.
Genetic risk-targeted islet autoantibody screening for presymptomatic type 1 diabetes in adults www.thelancet.com/journals/lan...
Cool stuff -> Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation jamanetwork.com/journals/jam...
Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1... tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
Nice work from Iftikhar Kullo and co on incorporating polygenic, monogenic and family history risk into the Pooled Cohort Equations for coronary heart disease risk. Assessed across spectrums of age and ethnic diversity using All of Us and eMERGE IV. www.medrxiv.org/content/10.1...
Wow, a whole new way to 'see' our Milky Way! Radiowave light (top) as compared to visual light (bottom). h\t Western Australia and ICRAR! www.icrar.org/gleam-x-gala...