Nature Communications
@natcomms
Nature Communications is an open access journal publishing high-quality research in all areas of the biological, physical, chemical, clinical, social, and Earth sciences. www.nature.com/ncomms/
RPL22L1 shown to regulate translation of mRNAs related to DNA repair such as ATRX, and, consequently, RPL22L1 loss sensitizes cancer cells to chemotherapy doi.org/10.1038/s414...
Two recent papers, and the associated Comment piece, identify the cardiac protein Leiomodin 2 as an actin filament polymerase enabling growth from filament pointed ends http://dlvr.it/TTvYgs http://dlvr.it/TTvYgt http://dlvr.it/TTvYgw
NANS-mediated recruitment of USP7 stabilizes LATS2, driving tumor growth and resistance to endocrine therapy and #CDK4/6 inhibitors in #breastcancer doi.org/10.1038/s414...
#Obesity driven loss of gut microbial #GABA promotes metabolic changes that accelerate #colorectal cancer progression doi.org/10.1038/s414...
#EnvironmentalMicrobiology Co-migration of hundreds of microbial species over metres drives selection and promotes non-motile hitchhikers @susiegriggo.bsky.social @flinders.university.bsky.social #chemotaxis #metagenomics 🦠 http://dlvr.it/TTk6X2
A phase 1/2 #clinicaltrial of #copanlisib in combination with the PD-1 inhibitor #nivolumab for patients with metastatic microsatellite stable #colorectalcancer doi.org/10.1038/s414...
The Serology Puzzle: Untangling Cross-Reactivity in Arbovirus Diagnostics #arbovirus #surveillance #serology #modelling #epidemiology @vyman.bsky.social @mtwhite.bsky.social http://dlvr.it/TTY9fS
Lung CD34+ fibroblasts found to promote the formation of a #premetastatic #niche via an upregulation of IFN-I response that drives cytotoxic NK and T-cell exhaustion doi.org/10.1038/s414...
#Replication stress-associated p21 expression marks proliferating juvenile #osteoblasts within a Hedgehog-dependent niche, while c-Myc activation and p53 loss cooperate to drive Hedgehog-independent #osteosarcoma formation doi.org/10.1038/s414...
🦠 #Microbiology 🔬 New featured image on our homepage! http://dlvr.it/TT7dMW Read the #openaccess article: True cyst formation underlies persistence and drug tolerance in Tritrichomonas foetus http://dlvr.it/TT7dMX @intechchascomus.bsky.social #Parasitology
An induced pluripotent stem cells-derived NF1-CDKN2A-PRC2-deficient model mimics malignant peripheral nerve sheath tumors, and can be used for drug combinations discovery doi.org/10.1038/s414...
#PublicHealth : Global travel hubs could be key in future pandemic surveillance efforts. Here, the authors show that traveler-focused genomic surveillance at key hubs can speed up detection of SARS-CoV-2 variants under resource constraints http://dlvr.it/TSkYyK
#MicrobialEcology : Genome-centric metagenomics reveals electroactive syntrophs in a conductive particle-dependent consortium from coastal sediments @ameliarotaru.bsky.social @nordcee.bsky.social #methane #metagenomics #electromicrobiology http://dlvr.it/TSbqJY
#Symbiosis Magnetoreception in a freshwater ciliate arises from endosymbiosis The endosymbiotic bacteria produce magnetite crystals, allowing the protist to move efficiently in stratified waters http://dlvr.it/TSZp8Y
#CRISPR base-editor #screens predict shared and drug-specific MEN1 #resistance mutations across five clinical menin inhibitors doi.org/10.1038/s414...
Discovery that endocrine therapy upregulates Rac1 signalling component P-Rex1, and inhibition of Rac1 reduces tumor growth in refractory breast cancer models doi.org/10.1038/s414...
Finding that ZEB1-mediated repression of ELMO3 creates a synthetic-lethal dependence on ELMO2, and that inhibiting ELMO2 selectively kill mesenchymal-like cells and EGFR TKIs–resistant cancer cells doi.org/10.1038/s414...
FOXA1 loss in mice shown to drive basal-squamous de-differentiation and to remodel the tumor microenvironment in prostate cancer doi.org/10.1038/s414...
Announcing Nature Progress Oncology! An open-access journal in the new Nature Progress series, publishing significant advances in cancer research, from cell biology and immunology, therapeutics, clinical research, and epidemiology nature.com/natprogoncology
Announcing Nature Progress Brain Health! A new open-access journal bringing together timely research across the full landscape of brain health, including preclinical and translational neuroscience, neurology, and neuropsychiatry nature.com/natprogbrainhealth
Intermediate #PRRX1 levels primes #cancer cell for high invasion and metastatic fitness, whereas extreme expression leads to cell cycle inhibition and #dormancy doi.org/10.1038/s414... @ruljcz.bsky.social @nietoangela.bsky.social
#LRRK2 inhibitors found to enhance viral infection and oncolysis by oncolytic herpes simplex virus #therapy in #glioblastoma doi.org/10.1038/s414...
eIF6 identified as a regulator of #SCLC small cell lung carcinoma #plasticity, driving non-neuroendocrine transdifferentiation via regulation of the CD104/FAK complex doi.org/10.1038/s414...
Discovery that #obesity induces the expression of the peptide hormone cholecystokinin (CCK) in #β-cells, affecting the peri-islet acinar cells and promoting islet-proximal #tumor formation @muzumdarlab.bsky.social @krishnaswamylab.bsky.social doi.org/10.1038/s414...
RIPK1-driven #necroptosis in both tumor and stromal compartments found to be essential for effective immunogenic cell death-based therapy and immune checkpoint @meierlabicr.bsky.social doi.org/10.1038/s414...
www.nature.com/articles/s41... Satellite data and experiments show #heatwaves and extreme rain, more than gradual warming, drive lake algal blooms by accumulating #phosphorus and forming dense particles to sink to cooler water, and pre-heatwave rainfall intensifies their outbreaks.
www.nature.com/articles/s41... This study shows O2-producing #cyanobacteria likely prospered in silica- and iron-rich ancient oceans prior to the emergence of free O2. Silica and day-night light cycles helped the #microbes to overcome toxicity effects caused by oxygen radicals.
Discovery that hyaluronic acid promotes homotypic and heterotypic circulating tumor cell clustering by initiating early cell contacts and stabilizing mature interactions doi.org/10.1038/s414... #BCM #BreastCenter