Simon Fisher
@profsimonfisher
Director of Language & Genetics at Max Planck Institute, Nijmegen. Tracing the complex connections between genes, brains, speech & language. Website: ORCID:
A privilege & a pleasure to co-lead the 6th run of our “Genetics & Neurobiology of Language” course at the beautiful @cshlbanbury.bsky.social campus. Huge thanks to inspirational speakers, our fab TAs, talented early career researchers who joined as participants, & all who helped make it so special.
Science reporters seem to love chasing stuff like this right now. For what it's worth, the self-declared biohacker has not cloned himself. See also the proliferation of credulous pieces on de-extinction gurus & designer baby grifters. Creates confusion & hot takes in lieu of informed conversation. 🧪
If only he'd been called UneventfulJaunteus, so much pain & suffering could have been avoided.
Tsoukalos: And the answer is YES! Reality: The answer is no. But admittedly that is based purely on hundreds of studies of FOXP2, its evolutionary history over millions of years, its functions in species including humans, mice, bats, birds, frogs, fish etc. + copious evidence-based research. 9/n
Tsoukalos: So my question is, is it possible that this gene was given to us or grafted into us by extraterrestrials in the remote past? Reality: [bangs head repeatedly against desk while quietly sobbing] 8/n
Tsoukalos: So this gene exists out of NOWHERE without ANY origin. Reality: Are you even paying attention? The very first study of the human gene (back in 2001) pointed out that it’s also present in mice! There are only 2 protein-coding differences between human FOXP2 & its counterpart in chimp! 7/n
Tsoukalos: There is absolutely NO EVIDENCE OF ORIGIN or that this thing somehow mutated from the animal kingdom towards us. Reality: By sequencing versions of FOXP2 found in many species, scientists have traced its origins & the ways it changed over hundreds of millions of years of evolution. 6/n
Tsoukalos: Scientists have suggested that THAT GENE ALONE is responsible for language. Fisher, Lai, Monaco [scientists who discovered FOXP2]: “It must be emphasized that this is likely to be just one of many genes involved in speech & language.” Annu Rev Neurosci, 2003 www.mpi.nl/publications... 5/n
Tsoukalos: It is something that sets us COMPLETELY APART from any other animal. Reality: Versions of FOXP2 are found in similar form in a great many distantly related species; humans, other apes, monkeys, rodents, bats, birds, reptiles, fish... This is a gene with a deep evolutionary history. 4/n
It begins badly then heads rapidly downhill. Tsoukalos: FOXP2 is a gene that was found in our nucleotides. Reality: Like other genes, FOXP2 is made of nucleotides. That is, nucleotides are found in FOXP2, not the other way around. I’m being pedantic, of course, but we’re just getting started ... 3/n
One big source of FOXP2-alien nonsense is a TV “documentary” series on the History Channel. In their segment on FOXP2 (first broadcast in 2011) a man named Giorgio Tsoukalos makes 5-6 statements about the gene, each of which is false. All packed into less than one minute’s viewing. Let’s dig in. 2/n
25 years ago, we implicated rare variants of the FOXP2 gene in a severe speech disorder. I’ve spent much time stressing that FOXP2, while interesting, is not the mythical “gene for language”. Weirdly, on occasion I also need to explain why it’s not “proof of aliens”. Full disclosure in this 🧵. 1/n 🧪
Brighten up your day by watching this ingenious little bumble bee spontaneously solving a novel object manipulation task. Source: www.science.org/doi/10.1126/... 😊🐝🧪
CRISPR gene-editing has revolutionized what we do in the lab. But what nobody talks about is how difficult it is to find the tiny scissors when you accidentally drop them in the middle of an experiment.
Continuing my thread of threads on popular (mis)understanding of human genetics. How iconic images like “The March of Progress” fuel major misconceptions about the way evolution works: 🧬🧵🧪👇
“Carbon is an open-source autoregressive foundation genomic model that understands and writes DNA...“ especially if you want your double-helix twisting the wrong way, as shown in the big fancy animation currently adorning the website of this new AI tool.
This telephone cord has spontaneously organized itself into a right-handed double-helix & that delights me more than you can possibly imagine. 🧬
You should definitely check out the new updated 10th anniversary edition of @adamrutherford.bsky.social's classic “A Brief History of Everyone Who Ever Lived”. If only so that you can better this insightful & helpful one-star review he received for the original.
POW! For perhaps the quintessential sighting of a left-handed double-helix in the wild, check out this genuine screenshot I took a few years ago of a company selling their extremely dubious “Superhero DNA test” to unwitting consumers.
And the “de-extinction” grift continues. Your regular reminder that it's only a dire wolf if it comes from the Late Pleistocene epoch, otherwise it's just sparkling dog.
Exclusive never-before-seen footage of the Artemis II moon mission, captured by the great @tomgauld.bsky.social:
No "difficult second album syndrome" for these guys - they followed up their debut less than a year later with another stone cold classic. Like their first, this got heavy rotation in my home when I was a kid:
Going through a box of old vinyl LPs, came across this absolute gem from my childhood, one of the finest albums of the 1970's: