Rosetta Commons

@rosettacommons

Rosetta Commons is the central hub for hundreds of developers and scientists from ~100 universities and laboratories to contribute and share the Rosetta source code. Rosetta Commons members develop software improvements to solve their unique queries.

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Rosetta Commons@rosettacommons· 22d

Sometimes the hardest part of working with new tools is installing them. Watch this helpful tutorial to learn how to install RFDisffusion3 with Foundry so you can start experimenting with protein design today. www.youtube.com/watch?v=6rFE... #rcmegathon #rctutorial

Rosetta Commons@rosettacommons· 26d

In Spring 2026, the FEBS Advanced Practical Course on Generative AI for Protein Engineering was hosted in Belgium, where students participated in training on protein design pipelines. Then, CNPEM in Brazil hosted its annual Open Science Event introducing people to protein design through Foldit.

Rosetta Commons@rosettacommons· 28d

RFdiffusion3 is a powerful tool for binder design. The newest tutorial from Rosetta Commons provides step-by-step guidance for how to design binders for simple proteins, small molecules, and proteins with post-translational modifications. www.youtube.com/watch?v=q1tS... #rcmegathon #rctutorial

Rosetta Commons@rosettacommons· Jul 8

Only one week left to register for RosettaCon Asia. As protein design enters a transformative era, join the conversation on how new computational methods and experimental approaches are reshaping what is possible in biology. To register, visit rosettacommons.org/events/rcasia

Rosetta Commons@rosettacommons· Jul 7

In the search to find a good metric for complex protein folds, the Pacesa Lab has created the FoldComplexity voting site. The results from weekly voting will be used to update subsamples of protein chains in the PDB to help better calibrate the metric. Check it out: pacesalab.com/foldcomplexity

Rosetta Commons@rosettacommons· Jul 6

We’re back! Tomorrow, July 7 is the next Protein Design Workflows Group presentation. Join us via Zoom for an exciting presentation and discussion around BioPipelines by Gianluca Quargnali. For more information and the Zoom link, join the group’s mailing list: groups.google.com/g/protein-de....

An announcement of a presentation from the protein design workflows group. The talk is titled BioPipelines and is by Gianluca Quargnali of the University of Zurich. It is announced that the talk is July 7, 2026 at 5 p.m. CET or 11 a.m. ET via Zoom. There is an image of three protein spirals in different shades of blue labeled AlphaFold: folded and Prediction of new structures.

Rosetta Commons@rosettacommons· Jul 1

The scientific community is currently debating how to balance open research with biosecurity protections when it comes to biological AI tools. Primarily designed for broader societal benefits, could these tools also provide opportunities for misuse? Where do you stand? zurl.co/ccYXT

Rosetta Commons@rosettacommons· Jun 30

Please use this updated image and see our thread on this post regarding the old image. Thank you!

Rosetta Commons@rosettacommons· Jun 30

European RosettaCon is sold out! Registration is now closed. Conference organizers will be in touch with registered participants soon regarding talks, posters, and travel grants. Stay up to date on the conference by visiting europeanrosettacon.org.

An image of the Padrãos does Descobrimentos (Monument to the Discoveries) sculpture in front of purple and orange lit clouds during sunset. The portion of the sculpture shown is primarily white colored and shows one man dressed in clothes from the late 15th century with the man in the front holding a model of a sailing ship. The text on the image says, “European RosettaCon, Lisbon, Portugal, Sold Out, Registration Closed, 28th to 30th of October, 2026, Rectorate of the NOVA university of Lisbon, europeanrosettacon.org” It has the NOVA, SPBf, Rosetta Commons, and Rosetta Design Group logos at the bottom of the image.

Rosetta Commons@rosettacommons· Jun 24

Biohub has released updates to open source ESM protein language models. The models were used to generate the ESM Atlas, which maps 6.8 billion sequences and 1.1 billion predicted structures to protein functions. Alex Rives (Head of Science) is a keynote speaker for Summer RosettaCon. zurl.co/6qQdT

Rosetta Commons@rosettacommons· Jun 23

Meet Thomas! Thomas’ lab focuses on developing computational tools for determining 3D structures, including research into genetic code expansion and paramagnetic NMR to understand protein-protein interaction and molecular dynamics. Learn more about Thomas in our June 2026 newsletter. zurl.co/2QTmm

Rosetta Commons@rosettacommons· Jun 17

OpenBind is generating high-quality protein-ligand datasets that link structural data with binding measurements. This first release provides a realistic, structurally novel testbed linking high-resolution crystallographic data directly with biophysical binding affinity. zurl.co/PVCnJ

Rosetta Commons@rosettacommons· Jun 14

Registration closes June 15 for the Leipzig Rosetta Workshop on August 17 - 21, 2026 in Leipzig, Germany. Participants, from all career stages, will work on applications such as enzyme design, binder development, and vaccine-related protein engineering. Apply today: meilerlab.org/leipzig-work...

Rosetta Commons@rosettacommons· Jun 10

Abstracts for the first RosettaCon Asia, hosted by Peking University, are due June 15 with registration closing July 15. Join leading scientists in Beijing, China on October 10 - 11 to dive into discussions about the transformative era of protein design. To learn more, visit zurl.co/DkaQK

Rosetta Commons@rosettacommons· Jun 8

Registration for the 2nd Symposium on Protein Design and Engineering (RosettaCon Brazil), hosted by CNPEM, closes on June 15. Join the discussion on AI for protein design in Campinas, Brazil on October 5-8. A travel grant for a postdoctoral researcher is also available, learn more: zurl.co/dsjlS

Rosetta Commons@rosettacommons· Jun 5

Welcome to our 2026 REU trainees! They spent the week at John Hopkins University completing an introductory bootcamp focused on machine learning and Rosetta software and tools. We can’t wait to see what they accomplish over the summer at their host labs throughout the US and Europe. zurl.co/LhlOI

Group photo of REU trainees on a brick pathway next to trees.

Group photo of REU trainees jumping while standing in a line on a brick pathway next to trees.

Rosetta Commons@rosettacommons· Jun 3

Join us October 28 - 30 as we gather in Lisbon for three days of exciting speakers, engaging discussions, and valuable connections at European RosettaCon. General registration is now open, but only a few spots remain. Register today at europeanrosettacon.org.

Rosetta Commons@rosettacommons· Jun 1

Applications close this Friday, June 5, for the ML & Rosetta Intro Bootcamp. This immersive, novice-level bootcamp is designed for students and researchers who are new to computational protein design as a way to learn both machine learning tools and Rosetta. Apply today: zurl.co/ISb1i

Rosetta Commons@rosettacommons· May 29

Registration is now open for the Leipzig Rosetta Workshop on August 17 - 21 in Leipzig, Germany. The hands-on workshop is focused on the latest computational protein design methods using Rosetta and AI-based tools such as RFdiffusion and ProteinMPNN. Applications close July 1, 2026: zurl.co/UTyIs

Rosetta Commons@rosettacommons· May 28

Prof. Cecilia Clementi is a pioneer in bridging machine learning, molecular simulation, and experimental data to decode the complexity of protein dynamics. Hear about her group’s latest advances at European RosettaCon 2026. Early bird registration closes this Sunday, May 31. europeanrosettacon.org

An announcement of Cecilia Clementi as a keynote speaker for European RosettaCon. It notes she is from Freie Universität Berlin and her talk will be titled Understanding protein dynamics with machine learning, simulation, and experimental data. At the bottom are the logos for NOVA University, SPBf, Rosetta Commons, and Rosetta Design Group. The background has a purple colored sky at the top and then an off-white background for most of the image with some purple spirals on the sides.

Rosetta Commons@rosettacommons· May 27

Meet Anum! Anum’s lab looks at how proteins change conformations at different timescales to perform functions, how this behavior evolves, and how to capitalize on this knowledge to engineer new proteins with very sophisticated functions. Learn more in our May 2026 newsletter. zurl.co/OzCxg

Rosetta Commons@rosettacommons· May 22

Join us July 20-24, 2026 for the ML & Rosetta Intro Bootcamp at John Hopkins University. The bootcamp will be a blend of lectures and hands-on projects to introduce and then practice key concepts and skills with Rosetta and machine learning. Applications close June 5. Apply now: zurl.co/N6eSW

Rosetta Commons@rosettacommons· May 19

European RosettaCon 2026 will bring together the field's leading voices in computational protein design, machine learning, and structural biology, for three days in Lisbon this October. Don't miss the window for early bird pricing by registering before it closes May 31. europeanrosettacon.org

Rosetta Commons@rosettacommons· May 18

Protein design is entering a transformative era, where new computational methods and experimental approaches are reshaping what is possible in biology. Hosted by Peking University, RosettaCon Asia will take place October 10 - 11, 2026 in Beijing, China. Registration is now open. zurl.co/Y4D9F

Rosetta Commons@rosettacommons· May 14

Tomorrow is the last day to register for Summer RosettaCon 2026! Grab a seat at the table for discussions around protein design and deep learning, structural modeling of proteins, antibody and vaccine design, enzyme design, protein language models, Rosetta code tutorials, and more! rosettacon.org

Rosetta Commons@rosettacommons· May 12

PyRosetta now comes packaged with type stub files to streamline the development experience when writing Python code using the PyRosetta library. Read more: zurl.co/goarX

Rosetta Commons@rosettacommons· May 11

Summer RosettaCon 2026’s opening keynote will feature 2024 Nobel Prize winning computational biologist David Baker. Director of the Institute for Protein Design, David’s lab explores de novo protein design for solving complex challenges in medicine and technology. zurl.co/BGPAt

Rosetta Commons@rosettacommons· May 7

The Protein Design Workflows series brings together researchers and developers to discuss how protein design pipelines are built, run, and scaled in practice. Videos of the presentations from January through April are now available on the Rosetta Commons YouTube channel. zurl.co/W8tIo

Rosetta Commons@rosettacommons· May 6

Prof. Frank Noé is a leading figure at the intersection of machine learning and molecular science, with pioneering contributions that are reshaping our field. Hear his perspective at European RosettaCon 2026. Early bird registration closes May 31. europeanrosettacon.org

An announcement of Frank Noé as a keynote speaker for European RosettaCon. It notes he is from Freie Universität Berlin and Microsoft Research AI for Science and his talk will be titled Biomolecular dynamics and function at scale. At the bottom are the logos for NOVA University, SPBf, Rosetta Commons, and Rosetta Design Group. The background has a purple colored sky at the top and then an off-white background for most of the image with some purple spirals on the sides.

Rosetta Commons@rosettacommons· May 5

Summer RosettaCon 2026’s closing keynote will feature Alanna Schepartz. Alanna pioneered the design of miniature proteins and b-peptide bundles and her lab continues to develop creative applications for synthetic biology and to study the mechanisms of protein-DNA recognition. zurl.co/2dNc2