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@rthm

RTHM is a secure health platform that makes it easy to gather your records, connect the dots with AI, and affordably access treatments.

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rthm_health@rthm· 19d

In our webinar on the Long COVID Treatment Guide, PLRC patient advocate Charlie McCone shares how he found the motivation to re-engage with treatment after feeling demoralized by the trial-and-error process. Listen to the full webinar: youtu.be/VdfPnwz7fmA

rthm_health@rthm· 28d

Have you tried pyridostigmine for Long COVID, ME/CFS, Orthostatic Hypotension, or POTS-related symptoms? Swipe to learn why some RTHM users are finding pyridostigmine to be a helpful tool in managing complex chronic illness. Click here to get started: www.rthm.com

rthm_health@rthm· Jul 8

In our latest webinar, Dr. Binita Kane and Dr. Jennifer Curtin discuss how Dr. Kane uses the Long COVID Treatment guide in her clinic in the UK. She highlights how the guide brings key treatment options into one concise, practical resource for both providers and patients. youtu.be/VdfPnwz7fmA

rthm_health@rthm· Jun 25

In our webinar on the Long COVID Treatment Guide, Dr. Zachary Spiritos and PLRC patient advocate Charlie McCone discuss tips on how patients can share this guide with clinicians in a way that may help a doctor’s visit be more successful. Watch the full webinar: youtu.be/VdfPnwz7fmA

rthm_health@rthm· May 29

Join RTHM, Patient-Led Research Collaborative (PLRC), Dr. Zachary Spiritos, and Dr. Binita Kane on June 12 at 9:30 a.m. PST // 12:30 p.m. EST // 5:30 p.m. GMT+1 for a live discussion on the new Long COVID Treatment Guide. Register here: us06web.zoom.us/j/8738963156...

rthm_health@rthm· May 27

SARS-CoV-2 Omicron variant spike protein maintains the ability to bind and activate human platelets: Comparison with the wild-type

This study found that both wild-type and Omicron SARS-CoV-2 spike proteins significantly increase platelet binding and ADP-induced P-selectin expression compared to controls. The Omicron spike protein uniquely increased platelet aggregation under SFLLRN stimulation, suggesting a persistent prothrombotic risk across viral mutations.

rthm_health@rthm· May 27

Acute COVID-19 is associated with altered CD8 T-cells indicative of impaired ability to control Epstein–Barr virus reactivation

The study found significant reactivation of Epstein-Barr Virus (EBV) in 72.7% of patients with critical COVID-19 and 67.9% with moderate COVID-19 at hospitalization, suggesting a link between EBV reactivation and the development of Long COVID symptoms. Notably, patients with EBV reactivation displayed altered CD8 T-cell activation profiles characterized indicating impaired viral control.

rthm_health@rthm· May 27

Endovascular profiles linked to neutrophil activation in children and young adults with long COVID
This research highlights that children and young adults with long COVID exhibit significant endovascular profiles, characterized by elevated microclots and markers of endothelial injury, underlying their debilitating cardiovascular symptoms. Increased neutrophil activation, evidenced by elevated cell-free DNA and altered cytokine levels, suggests that intravascular NETosis may drive endovascular pathology.

rthm_health@rthm· May 27

On the Correspondence of Diseases Showing Microparticles, Fibrinaloid Microclots and Disorders of the Microcirculation doi: 10.20944/preprints202604.1728.v1

The research highlights a significant relationship between cell-derived microparticles and fibrinaloid microclots in various chronic inflammatory diseases, indicating that their co-occurrence reflects underlying endothelial damage and protein misfolding processes. Both microparticles and microclots are consistently associated with microcirculatory disturbances across multiple conditions, suggesting they may serve as interconnected biomarkers for diagnosing and understanding the pathophysiology of these disorders.

rthm_health@rthm· May 27

Want to know how the latest Long COVID research relates to your case? Here are 5 recent publications related to Long COVID, ranging from immune and vascular changes to viral reactivation. Sign up to receive studies curated to your health & topics of interest: www.rthm.com/research-cor...

Impaired peripheral oxygen delivery during submaximal exercise in adults with long COVID PMID: 42026739

This study on Long COVID (LC) reveals that individuals exhibit impaired muscle oxygenation and recovery during repeated exercise. Specifically, LC participants showed compromised peripheral oxygen extraction, and their physical performance declined significantly on a second exercise day compared to controls. The findings suggest that tissue hypoxia may contribute to the exacerbation of symptoms in LC.

rthm_health@rthm· May 20

In POTScast Ep 306, Dr. Jennifer Curtin and patient advocate Charlie McCone explain how the Long COVID Treatment Guide, a collaboration between RTHM & PLRC, helps patients and clinicians have meaningful conversations about treatment options that can be considered as part of a personalized care plan.

rthm_health@rthm· Apr 22

About the Long COVID Treatment Guide
The Long COVID Treatment Guide is meant to spark meaningful conversations with patients and their clinicians about potential treatment options that could become part of a personalized care plan. It offers thoughtfully selected options clinicians and patients can explore together, based on the unique symptoms, needs, and goals of each patient.

The focus is primarily on 24 prescription medications, but also includes select supplements and over the counter medications, procedures, and lifestyle strategies.
References
PMID: 33536023, 36969241, 38813984, 40627388, 37793728, 37419575
A Collaboration between Patient-Led Research Collaborative and RTHM
PLRC x RTHM Long COVID Treatment Guide
03

rthm_health@rthm· Apr 22

The Harvard/Stanford TREATME Study
22% of individuals with Long COVID or ME/CFS who tried rapamycin (n=18) reported “moderate to much better” symptom improvement.
References
40627388, DOI: 10.21203/rs.3.rs-6596158/v1; Trial ID: NCT06960928
A Collaboration between Patient-Led Research Collaborative and RTHM
PLRC x RTHM Long COVID Treatment Guide
03

rthm_health@rthm· Apr 22

Summary
Findings from a phase one trial on ME/CFS patients found that weekly rapamycin doses of up to 6 mg significantly improved fatigue, sleep, and orthostatic intolerance over three months. These findings suggest rapamycin’s potential as a treatment, likely due to its autophagy-promoting and mTOR-inhibiting properties, with further analyses expected to provide deeper insights.

A clinical trial studying low dose rapamycin in people with ME/CFS and people with Long COVID is also currently underway.
A Collaboration between Patient-Led Research Collaborative and RTHM
PLRC x RTHM Long COVID Treatment Guide
03

rthm_health@rthm· Apr 22

Especially Helpful For
Myalgic encephalomyelitis
chronic fatigue syndrome (ME/CFS)
cognitive impairment
fatigue
post-exertional malaise (PEM)
Notes
Titrate from 1mg 1x weekly up to 6mg 1x weekly. Good to get baseline markers of CMP, CBC, lipids, fasting glucose, A1C and fasting insulin before starting. Not all markers are required, but it can cause some insulin resistance and elevated lipids and LFTs in some people, particularly early on.
A Collaboration between Patient-Led Research Collaborative and RTHM
PLRC x RTHM Long COVID Treatment Guide
03

rthm_health@rthm· Apr 22

PLRC and RTHM Clinic recently released the Long COVID Treatment Guide to support more informed conversations between patients and their clinicians. Today, we’re highlighting rapamycin, a medication that has shown promise for those with ME/CFS and Long COVID. Download the guide here rthm.com/treat…

rthm_health@rthm· Mar 27

Have you tried Low Dose Naltrexone (LDN) for Long COVID, ME/CFS, or other chronic illness symptoms? Please share in comments. According to real-world data, 57% of RTHM Platform users who had taken LDN reported improvements, and 38% of those described the benefits as significant. www.rthm.com

Top Symptom Improvements

24% Experienced reduced fatigue

18% Had improved mental clarity

11% Saw reduced post-exertional malaise

18% Saw reduced aches and pains

rthm_health@rthm· Mar 23

RTHM’s Take:
“The growing evidence surrounding the impact of Long COVID in school-age children stands in stark contrast to the dearth of public health information parents, teachers and educators are receiving about the condition. Chronic absenteeism remains high in the United States compared to pre-pandemic levels, and this study makes a compelling case for Long COVID playing a significant role in driving this sustained change. Long COVID urgently needs to be a priority for discussion and action between our education institutions and public health institutions.”

“— Jennifer Curtin, MD, RTHM Co-Founder

rthm_health@rthm· Mar 23

Study Author Conclusions:
“Together, our findings suggest that long COVID has a potentially large impact on US school-aged children. Parents, caregivers, teachers, and schools may consider that children with long COVID disproportionately experience both functional limitations and sick days off from school.”

“From 2018–19 to 2021–22 enrollment-weighted prevalence of chronic absenteeism in the United States increased from 14.8% to 28.3%, a 91% increase relative to the prepandemic timeframe… Schools might consider health-related factors in their ongoing efforts to improve school attendance and could collaborate with healthcare systems to provide integrated systems of support to address complex needs for children with disabilities and health concerns.”

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rthm_health@rthm· Mar 23

What This Suggests
Long COVID in children may have meaningful downstream impacts on learning and social development because it’s linked to both functional limitations and higher illness-related absenteeism.

Authors propose considering school accommodations (e.g., reduced workload, rest periods), analogous to supports used for conditions like concussion or ADHD.

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rthm_health@rthm· Mar 23

Key finding: long COVID is linked to much more illness-related school absence
Missing >30 days for illness/injury in the past year: 10.7% with Long COVID vs. 1.5% without Long COVID.

Illness-related chronic absence (>18 days): 13.9% with Long COVID vs 3.5% without Long COVID

To reduce confounding from acute COVID-related school absences, the authors also analyzed a subset of 4,587 children with prior COVID-19. In this prior-COVID subsample, illness-related chronic absence was 13.9% (ever long COVID) vs 4.9% (never long COVID, but prior COVID).

Having Long COVID at some point was associated with 2.5x the odds of illness-related chronic absenteeism compared with never having had Long COVID.

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rthm_health@rthm· Mar 23

Key finding: Long COVID is linked to higher rates of functional limitations
Compared with children who never had Long COVID, those who ever had Long COVID showed higher prevalence in multiple domains, including:
Learning difficulty: 19.8% vs 10.4%
Difficulty concentrating: 14.3% vs 7.7%
Difficulty with memory: 18.3% vs 8.6%
Weekly/daily depression: 18.9% vs 6.2%

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rthm_health@rthm· Mar 23

Description of the Study:
Using a nationally representative US survey of 11,057 US children aged 5–17 years, the authors asked whether children with Long COVID report more functional limitations and more illness-related chronic school absenteeism than peers without Long COVID.

Authors classified illness-related chronic absenteeism, according to the US Department of Education, as missing 18 or more school days in the past 12 months due to illness or injury.

The authors used the Washington Group/UNICEF Child Functioning Module (24 questions) for ages 5–17 years, covering multiple functional domains.

Long COVID was defined as children having any symptoms lasting >3 months that they did not have before having COVID-19.

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rthm_health@rthm· Mar 23

Long COVID may be affecting how some children learn and participate in school. In a survey of 11,000+ U.S. kids, those with LC were 2.5× more likely to experience chronic illness-related absenteeism and reported higher rates of learning, memory, & concentration difficulties. doi.org/10.3201/eid3...

Recent Study:

Long COVID among school-aged children associated with chronic absenteeism.

Authors: Nicole D. Ford, Regina M. Simeone, Caroline Pratt, and Sharon Saydah

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rthm_health@rthm· Mar 2

RTHM just made supplements a whole lot easier. You can now order high-quality supplements directly through RTHM, shipped straight from the manufacturer, at 25% off! Check out our HIPAA-compliant intelligence platform for supplement and treatment suggestions. www.rthm.com

rthm_health@rthm· Feb 20