Boland and colleagues combine single-cell mechanical measurements, computational modelling, and transcriptomics to reveal how vascular smooth muscle cells respond to high strain rate, showing how actomyosin drives softening as strain rate increases. buff.ly/TWXdoMY

Protein condensates growing at cell membranes is like soap bubbles swelling when they cling to a surface! Yohan Lee et al. 2025 show how transmembrane coupling fuels these liquid-like clusters to grow and organize! buff.ly/XkFYmgK

#OPENACCESS: Simulation reveals that the Mn2+ accelerates molecular rearrangements of platelet integrin that activates the protein for ligand binding. buff.ly/c0TPpYt

In the New and Notable "Pulling Frank-Starling into another dimension," Megan L. McCain highlights the paper "Biaxial length-tension relationship in single cardiac myocytes ." buff.ly/XliGXNu

Hatano et al. use image-based modelling to extend on their previous simulations of cardiomyocyte contraction, integrating electrophysiology, Ca²⁺ dynamics, and force generation to provide a new tool for exploring how cellular architecture shapes function. buff.ly/31jNTm4

#OPENACCESS: Peeking inside the nucleus is like reading a balloon’s shape to guess the air pressure! Alejandro Jurado et al. 2025 combine 3D shape analysis and elastic sensors to infer the forces cells feel in real time! buff.ly/i5CCmmT

Stretching the truth about the Frank-Starling Law – this New and Notable highlights Rothermel et al., who show that lattice spacing adds a new dimension to force when cardiac myocytes are stretched in non-longitudinal directions. buff.ly/XliGXNu

Meet the editor of Biophysical Journal, Vasanthi Jayaraman, at the Annual Meeting in Los Angeles, February 17, 10:00-11:15 am, Room 402AB, Los Angeles Convention Center.