IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. vist.ly/5dp9p

🔬 New research suggests that individuals exposed to Mycobacterium tuberculosis without developing active disease have stronger IgA and IgG antibody responses than TB patients. High salivary IgA levels also point to an important role for mucosal immunity in TB protection. vist.ly/5cuf7

🔬 New evidence suggests β-tubulin 5 (TBB5) is unlikely to be the pANCA target in primary sclerosing cholangitis (PSC), narrowing the search for the underlying autoantigen. 📖 vist.ly/5c73w #Immunology #Autoimmunity

🧬 New insight into rituximab resistance: CD40L and IL-4 shield B cells from NK cell-mediated killing via the HLA-E/NKG2A and HLA/KIR inhibitory pathways. Targeting these checkpoints could enhance B-cell depletion in autoimmune disease. 📖 vist.ly/5c37t

🧬 Targeting TIM pathways in RA? In a murine arthritis model, blockade of TIM-1 or TIM-3 reduced disease severity, inflammatory cytokines (IL-6, IL-17A, TNF-α), and joint damage, highlighting both receptors as promising therapeutic targets in rheumatoid arthritis. 📖 vist.ly/5btfj

Crohn’s disease lesions show enrichment of CD4⁺CD39⁺ TCRαβ⁺ TEM cells producing IL‑17/IL‑21 and terminally differentiated TCR Vδ1⁺ cells producing TNF‑α/IFN‑γ. Distinct inflammatory roles point to Vδ1⁺ cells as a potential therapeutic target. 📄vist.ly/5bipi

Despite elevated KLR and mitochondrial gene expression, Tregs in autoimmune PAI show normal frequency and suppressive function, suggesting limited involvement in disease pathogenesis. 📄 vist.ly/5ba6v

Important CIDP research shows significant changes in circulating B‑cell subsets and elevated IL10/TNFA expression, correlating with disability scores and nerve fiber density. Valuable insights for understanding disease activity. 📄 vist.ly/5b74h

This study highlights 2B4 (CD244) as a key receptor driving Staphylococcus aureus–associated allergic inflammation. SEB binds and activates 2B4, amplifying eosinophil responses, pointing to a promising therapeutic target. 📄 vist.ly/5aser

🧬 Research shows newborn immunity differs sharply from adults: NK cells and ILCs are functionally mature at birth, while NKT‑like cells are far less abundant and less active. Important context for understanding early‑life infection risk. 🔗 vist.ly/5ag5y

Type 1 Diabetes arises from a loss of immune tolerance. Our article explores how hyperglycaemia and immunometabolic changes may influence regulatory T cell function, offering new insights into disease mechanisms and therapeutic opportunities. 🔗 vist.ly/5adnr

📢 Explore the #FOCIS2026 Virtual Issue A curated virtual issue from Clinical & Experimental Immunology highlighting advances in immune microenvironments, immune evasion, and bioengineering 🧬 Discover the research shaping translational immunology: vist.ly/57h5j #Immunology

🎉 Registration is open for FOCIS 2026! 📅 June 9–12, 2026 📍 San Francisco Get ready to ignite innovation, connect with global immunology leaders, and experience the forefront of translational immunology at FOCIS 2026! Learn More: vist.ly/55krq #FOCIS2026

📢 New open‑access study identifies PSMB8 as a biomarker predicting proton pump inhibitor response in pediatric eosinophilic esophagitis, supporting more personalized treatment decisions. 🔗 vist.ly/53vqa

🧬 A rare SCID case highlights the complexity of inborn errors of immunity, showing how concomitant RAG‑2 and LRBA variants can coexist and why functional immunological testing is crucial when interpreting novel genetic findings, even years post‑HSCT. 👉 https://vist.ly/42fic

📢 Calling all translational and clinical immunology researchers! We welcome high‑quality studies with the potential to transform understanding of human disease or change clinical practice. Learn more about submitting: vist.ly/4ymyd

🔬 Open‑access study investigates how neutrophils contribute to multiple sclerosis. Using proteomics, it reveals altered granule proteins, shifts in pro‑inflammatory signalling, reduced T‑cell suppression, and enhanced Th17 differentiation in MS. Read: vist.ly/4tuwr

Highlighting this article that explores an alternative way of assessing mTOR inhibition therapy following kidney transplantation. Read the article here: https://bit.ly/4kyQn9w

This #WorldCancerDay, explore how bispecific T‑cell engagers (BiTEs) could strengthen T‑cell responses against solid tumours, and the challenges still holding them back. Read the open access review: https://bit.ly/4291Ipg #CancerResearch #Immunotherapy #BiTEs

🔬Maria Filika & Stergios Katsiougiannis explore how salivary gland epithelial cells in Sjögren’s syndrome actively drive and amplify autoimmune responses, reshaping how we view target tissues in autoimmunity. Read the open access review: https://bit.ly/4k6LOTH

📢 We’re welcoming high‑quality translational immunology submissions! If your research offers novel mechanistic insight into human disease, we want to hear from you. Submit your work: https://bit.ly/3LjuI2A

MOG/NMDAR overlapping syndrome is increasingly recognised. This review shows common symptoms (psychiatric changes, seizures), typical MRI patterns, good treatment response, but a notably higher recurrence rate. Read here📄 https://bit.ly/3Q2S29A

Working in immunology? Clinical & Experimental Immunology publishes impactful studies across six core sections plus areas like immunometabolism, mucosal immunity, and immunotherapy. Learn more about submitting your next manuscript to CEI: https://bit.ly/443pf8s

🎧 CEI Wrapped! A standout year for Clinical & Experimental Immunology! Thank you to our authors, reviewers and readers for helping CEI grow its reach and impact in 2025.

Well done to the recipients of this year’s BSI journals-sponsored Poster Prizes! 🎉 Congrats to Flavio Beke, Aisling Newing & Rébecca Barascud for their brilliant contributions. 👏 Read more: https://bit.ly/3MljD6r

Rotavirus vaccines save lives, but CMV exposure may reduce responses in some infants. New research highlights this challenge in HIV-exposed, uninfected babies, underscoring the need for equity in early-life health. 📖 Learn more: https://bit.ly/3DX1oAq #WorldAIDSDay #Immunology #ChildHealth

🦠 How do gut cells shape infections? This study, part of the Review Series - Organoids to Study Immune Cells Development and Function (Ed. Joana Neves), uses organoids to reveal how pathogens target specific cells! 🔬 Read more: https://bit.ly/422Z96U #GutHealth #Organoids #InfectiousDiseases

💙 On #WorldDiabetesDay, explore new insights into immune regulation in childhood #T1D. An Open Access study in Clinical & Experimental Immunology links Galectin-1 with inflammation & Treg cells in children with type 1 diabetes. Read more 👉 https://bit.ly/4r3C2Vw

Tomorrow marks #WorldDiabetesDay, check out this Open Access study: a new LIPS assay detects zinc transporter 8 autoantibodies (ZnT8A) quickly, safely, and with minimal blood, helping identify children at risk for type 1 diabetes. Read more 👉 https://bit.ly/3JBSPhw

New study finds IL-17 deficiency may underlie cryptococcosis in HIV-negative “immunocompetent” adults. Could unlock new paths for immunotherapy! 🦠🧬 Open access: https://bit.ly/47rL1Xq #Immunology #Cryptococcosis #IL17 #InfectiousDiseases