Elisa Fadda

@elisafadda

Associate Professor in the School of Biological Sciences at the University of Southampton, head chef at , Salem's butler, fucose fanatic #glycotime everyday! She/Her

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Elisa Fadda@elisafadda· 26d

Isn't it amazing when a fresh new preprint is out on Friday? 😎🥳 Check out the fabulous work by @beatricetropea.bsky.social who gives us a clear mechanistic explanation behind the 'peculiar' structure of the LLO donor preferentially chosen by eukaryotic OST 🤓😍 doi.org/10.64898/202...

Figure 1. Structural overview of the yeast OST complex and donor-binding site. (a) 3D structure of the yeast OST complex embedded in the ER membrane (brown sticks), showing the 8 subunits as surface color coded according to the labels. The lipid-linked oligosaccharide (LLO) donor is shown in orange and the backbone of the acceptor peptide is shown with a cartoon representation in yellow. The central panel shows the 2D SNFG representation of the LLO donor, with labels specifying glycosidic linkages and the nomenclature used for the branches. Below we show the sequence of an acceptor peptide, i.e. YJR1_N99, used as substrate in all MD simulations in this work, where the target asparagine was previously characterised as efficiently glycosylated(Khaleque et al. 2025). (b) Close-up view of the donor-binding pocket from the cryo-EM structure (PDB ID: 8AGC), showing the resolved LLO donor represented in sticks (orange) and SNFG symbols and the Stt3 N539 glycan (white). (c) Close-up view of the donor-binding pocket from the 3D model used in the MD simulations with the reconstructed N-glycans. The monosaccharides resolved in the cryo-EM structure are shown in white and orange as in panel b, whereas the monosaccharides added in the reconstruction of the full LLO donor and N539 glycan are highlighted in dark orange and grey, respectively. Rendering with Visual Molecular Dynamics (Humphrey, Dalke and Schulten 1996) (VMD) (https://www.ks.uiuc.edu/Research/vmd/).

Elisa Fadda@elisafadda· 27d

Meanwhile in Sardinia temperatures have reached today 47°C, which means 💀 zone #climateEmergency

Screenshot from an Ig post @raimeteo listing the temperatures reached in Sardinia (Italy) this afternoon with the corresponding location https://www.instagram.com/reel/Da29bgLNBNa/?igsh=cDBqYjN0YTRrcjRk

Elisa Fadda@elisafadda· Jul 11

Salem on the other hand is so stressed he had to take a nap

Salem (black cat) having a sleep on his favourite grey blanket with white polka dots

Elisa Fadda@elisafadda· Jul 11

Salem busying himself, helping around the garden #caturday

Salem (black cat) found one cool spot under the elder behind the lilac violets

Salem (black cat) behind the fern in the border (stones) under the fuchsia

Elisa Fadda@elisafadda· Jul 10

Excellent #glycotime in Bratislava for the #ICS2026 great catching up with so many amazing colleagues and friends about science, @glycoshape.org and all the fun stuff! 🥳 We had a fabulous time 😎

From left Ulrika Westerlind, me, Lara Mahal, Mark von Itzstein, Rob Woods, Vared Padler-Karavani, Matt Macaulay, Oren Moskovitz

Pistachio (top) chocolate (bottom) ice-cream cone with a wafer

Me during my talk, poster with sponsors on the left, me waving my arms as usual, and slide behind me (photo credit Mark von Itzstein)

Elisa Fadda@elisafadda· Jul 2

As a fun educational/inspirational #glycotime we decided to curate a Blog on glycoshape.org, you can find it under Resources or here glycoshape.org/blog You can *sign up* to get an email when we post a new entry The latest is E04:Let's talk about glycan binding to viral (glyco)proteins 🧪

Figure 1: Left. Structure of the SARS-CoV-2 S (gamma strain ectodomain; PDB 7sbs). Chains are represented in different colours, pink for chain A, grey for chain B and green for chain C, also in the legend at the bottom left corner. Right. Structure of an isolated RBD (grey surface) from the MD trajectory in complex with a GM1 oligosaccharide (C atoms in purple, O in red). The N345 glycan is not shown for clarity. The structures of the GM1 and GM2 oligosaccharides are shown below the RBD structure with SNFG symbols.

Elisa Fadda@elisafadda· Jun 27

Just back from super #glycotime at the 95th Harden Conference: Linking Golgi trafficking and glycan function in Blackburn 🧪 Brilliant talks and chats with new and old friends! I learned *so* much and realised how very little do I know about Golgi trafficking!! 🤯 Post on glycoshape.org/blog soon 😊

From the left hand side, me, Cathy Merry and Nadine Samara, photo courtesy of Iain Wilson

Left me, Cathy Merry, Nicola Stevenson, Lucy Paget (PhD student in my group) and Iain Wilson

The beautiful fields around the conference site with very happy cows in the distance

Elisa Fadda@elisafadda· Jun 27

Hot #caturday out there 🔥 drink loads of water, eat all the grass and find some shady vantage point for sneaking up on stuff 😎

Salem (black cat) adventuring in the green grass, hydrangea with white blooms on the left and a small conifer on the right

Elisa Fadda@elisafadda· Jun 21

That buddleia must be delicious 😋 white butterfly above and bumble bee below #wildflowerhour

Buddleia (pink) red brick wall green leaves DN white butterfly with two black spots and a black tip.

Elisa Fadda@elisafadda· Jun 18

Pls consider becoming a stem cell donor ❤️ to help fellow humans fight against blood cancers 💪🏻 It is super easy and absolutely free (check the link below ⤵️) I just did it myself, so I know 😊🙏🏻 Repost appreciated 🙂 www.dkms.org.uk

Letter containing the swabs kit in the (free) post. Red letterbox white envelope

Elisa Fadda@elisafadda· Jun 17

Button is loving this practice 🐱

Button (Calico cat) laying on her back on the a grey run with floral motifs

Elisa Fadda@elisafadda· Jun 17

Button has a leg extended there, trying too hard 😂

Button (Calico cat) laying on her back on the balcony

Elisa Fadda@elisafadda· Jun 14

Mallow with a bee covered in pollen #wildflowerHour

Elisa Fadda@elisafadda· Jun 13

Southampton #parkrun celebrates the amazing 1 million events 🎉 with a stunning day and the usual phenomenal turnout of 1178 parkrunners 😎☀️

Start of the Southampton parkrun in the Southampton Common, blue sky one fluffy cloud, green trees and grass and loads of people

Elisa Fadda@elisafadda· Jun 7

"When you were twelve or fourteen or six, a hundred per cent of your life was childhood. Even if you live to well into your nineties, adulthood will never be all of your existence" From Tenderfoot by Toni Jordan, a wholeheartedly wonderful book

Front cover of Tenderfoot by Toni Jordan (Hachette Australia) greyhound on the left, purple filter on the ground purple greenish sky with clouds and a small station wagon on the right

Elisa Fadda@elisafadda· Jun 4

Look at my beautiful cat holding a donut 🍩

Salem (black cat) laying on the floor holding a donut between his paws, looking beyond the (brown side, pink frosting top) donut, into the distance to infinity. Red reflective collar

Elisa Fadda@elisafadda· Jun 3

🚨 #glycotime seminar alert! June 22nd, 2026 4pm JST (8am BST) @kiyokof.bsky.social will present the GlyTouCan v.4 in the next GlySpace Alliance Seminar event 🔥 If you use @glycoshape.org, you know already aboutGlyTouCan IDs. Tune in ⬇️ to discover what GlyTouCan can do for your research 🥳

Elisa Fadda@elisafadda· May 30

It's #parkrun time! 😎

View over the start line at Southampton common parkrun, green grass, blue sky and about a record crowd!! 😁

Elisa Fadda@elisafadda· May 24

Scorchio May 2026 Bank Holiday weekend. Decided to go to Playa del Dorset at the stunning Durdle Door (not a very original idea as you can see) Amazing views, looks like the med🏖️🍹... until you get in the water 🥶 #UKBankHoliday #TheSunnySouth

View over the beach at Durdle Door (left side) crystal clear blue water and white cliffs of the Jurassic Coast

Left beach from the top of the hill, clear water and loads of people on the beach ⛱️

Durdle Door, classic photo with the pierced rock on the left, a billion people on the beach and white cliffs on the right

Elisa Fadda@elisafadda· May 23

💯 #parkrun 😎☀️

Elisa Fadda@elisafadda· May 19

Definition of an *absolute legend*!! 😎⤵️🐶🚲 #Bilbao

Seen in Bilbao at the traffic light, photo of a man in a blue shirt on his bicycle, with a dog sitting in the carrier basket with an elizabethan collar on, and a Palestine flag attached to the basket

Elisa Fadda@elisafadda· May 10

Prof Hugh Possingham at UW @hugepossum.bsky.social “I’ve never used any of them at all,” he says (..) he’s never clicked the button that generates or summarizes text when writing an e-mail" Same! 💯 Note: I changed the luddites' pic, a poor choice of cover imho ⤵️ www.nature.com/articles/d41...

A hand holding a piece of cardboard with a stop sign with AI barred in it

Elisa Fadda@elisafadda· May 10

From Chapter 2 "Iran", The Power of Geography by Tim Marshall, first published in 2021

Photo of a page from chapter 2 of the book the power of geography text highlighted in yellow is the most stunning example. Sorry my phone doesn't do the text capture and it is too long to transcribe

Elisa Fadda@elisafadda· May 9

Spectacular #parkrun day in the sunny south 😎

Southampton Common green grass, lush trees and sun shining through and on it all, absolutely wonderful

Elisa Fadda@elisafadda· May 7

Finally, we had such a great time with science and friends> I'll definitely miss this place ❤️🇩🇰 Fin

from left Bea, Silvia, Elisa and Ojas on the boat tour departing from Nyhavn

Elisa Fadda@elisafadda· May 7

Last but not least, 🙏 so much to Kresten @lindorfflarsen.bsky.social for his great hospitality, and for showing me around the very cool Copenhagen meat packing district, which was absolutely buzzing on a super sunny Friday and for a wicked nordic cuisine dinner! 🧵⬇️

Warpigs beer garden full of people drinking beer in the sushine, umbrellas on the left and right

view from the opposite side with more poeple and a rock band stage on the far end

Elisa Fadda@elisafadda· May 7

Today talk #2 at the stunning cgr.ku.dk My challenge this time was to follow Kaspar Locher's absolute masterclass on eukaryotic N-glycosylation, with a talk on OST substrate specificity and activity. 🙏 to Henrik and Hans and esp to Hiren and Adnan as 🔝 hosts @glyco.me @handle.invalid 🧵⬇️

View from the https://cgr.ku.dk/ best view of Copenhagen in Copenhagen

View of the tower where the https://cgr.ku.dk/ is located from outside, blue skies again!

Elisa Fadda@elisafadda· May 7

A fab, sunshiny week in 🇩🇰! Great #glycotime 🧪 at the CBM16 in Helsingør, with posters Bea: regulation of N-glycosylation by OST (doi.org/10.1101/2025...) Silvia: Siglec-6 high-recision recognition of glycolipids (doi.org/10.1038/s420...) Ojas: de novo binders design (doi.org/10.64898/202...) 🧵⬇️

From the left, Elisa, Ojas, Bea and Silvia. Blue skies above Helsingor, Denmark for the CMB16

Silvia (left) introducing her work on Siglec 6 (https://doi.org/10.1038/s42003-026-09609-8) in a flash talk at CBM16

Elisa (small with red jumper in the left corner) presenting GlycoShape in her "work along" part of the talk, with people in the audience rebuilding the glycosylation of IL5 on GlycoShape ReGlyco

Elisa Fadda@elisafadda· Apr 22

Wheeeee! 🎉 Loving this practice (Salem)

Salem (black cat) catching the fishes (blue) on a string with a fierce look

Elisa Fadda@elisafadda· Apr 22

Salem is trying, but he may have the wrong left side twist... 😎