The August issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Jihui Hao and colleagues showing senescent CAFs drive early-stage lymph node metastasis in PDAC via lactate-mediated metabolic-epigenetic rewiring - that and more aacrjournals.org/cancerdiscov... 👇

Now online in Cancer Discovery @aacrjournals.bsky.social: Follicular Lymphoma Transformation Is Characterized by Cytokine-associated Remodeling of Stromal and Macrophage Compartments doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Systematic Targeting of Protein Complexes with Molecular COUPLrs - by Diane Yang, Stefan Andrew Harry, Harrison Byron Chong, Neha Khandelwal, Edwin Zhang, John Iafrate, @liron1bar-peled.bsky.social, and colleagues doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Molecular and Structural Basis of Pan-Resistance to BTK Degraders and Inhibitors doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis - by Xiaowen Zhang, Mahak Singhal, @hellmutaugustin.bsky.social, and colleagues doi.org/10.1158/2159... @dkfz.bsky.social @uniheidelberg.bsky.social

Now in Cancer Discovery: two studies showing that CDK8 inhibitors act by trapping Mediator on chromatin & that cancers w/driver oncogenes acting as dosage-sensitive transcription factors (e.g. aRMS, Ewing sarcoma) are vulnerable to impairment of transcriptional regulatory complex dynamics:

In case you missed this Cancer Discovery paper in the news last week: First-in-Human Testing of a Mutant KRAS Vaccine for Pancreatic Cancer Interception in High-Risk Cohorts - by Daniel Haldar, Amanda Huff, Michael Goggins, Elizabeth Jaffee, Neeha Zaidi, and colleagues @aacrjournals.bsky.social

Now in Cancer Discovery @aacrjournals.bsky.social: Impact of Vitamin D on the CRC Immune Microenvironment: A Randomized Clinical Trial of Preoperative Vitamin D Supplementation in Patients w/Stage I-III CRC - by Andressa Dias Costa, Jonathan Nowak, Kimmie Ng, et al. doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Germline CDK12 Variants in Aggressive Prostate Cancer - by Sofie Tolmeijer, Colin Pritchard, Alexander Wyatt, and colleagues doi.org/10.1158/2159...

The July issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Jimin Min, Lisa Schweizer, Anirban Maitra, Andreas Mund et al. using AI-powered deep visual proteomics to reveal molecular transitions in pancreatic cancer - more here: aacrjournals.org/cancerdiscov...

It's been a pleasure to work with Dr. Vander Heiden so far and I look forward to the next era of Cancer Discovery under his leadership! Luis Diaz, Tali Lev, Lisa Situ, Robert Kruger, and I joined him for our first team meeting at #AACR26 (Michele Hartsough and I-Mei Siu were holding down the fort)

Now in Cancer Discovery @aacrjournals.bsky.social: Tumor Microbial Burden Drives Immune Responses via Regulation of Interferon Signaling - by Haoyue Liu, Jeong-Hoon Jang, Fuduan Peng, Hajar Rajaei, @linghua-wang.bsky.social , Luis Diaz, Florencia McAllister, and colleagues doi.org/10.1158/2159...

Now in Cancer Discovery @aacrjournals.bsky.social: Spatial Multiomics Implicate Tpex-B cell Interaction in Tertiary Lymphoid Structures after Neoadjuvant Therapy - by Jingying Huang, Yahui Chen, Peng Deng, Qian Kong, Konglan Lin, Ruijun Tian, Yiwen Lu, Shicheng Su, et al. doi.org/10.1158/2159...

EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway - by Pietro Scaparone, Alessia Mira, Taek-Chin Cheong, Roberto Chiarle, Chiara Ambrogio, and colleagues doi.org/10.1158/2159...

Targeting KRAS Codon 13 Mutations Using Direct Combination Approaches in Non-Small Cell Lung Cancer - by William McDaid, Helen Adderley, @drcolinlindsay.bsky.social, and colleagues doi.org/10.1158/2159... @cruk-mi.bsky.social @officialuom.bsky.social

Selective Inhibition of KRASG13C Reveals an Increased Dependence on Wild-Type RAS Isoforms in Codon 13 RAS-Mutant Cancers - by Kyle Seamon, Matthew Holderfield, and colleagues #RevolutionMedicines doi.org/10.1158/2159...

Now in Cancer Discovery @aacrjournals.bsky.social: Deconvolving SARS-CoV-2 mRNA Vaccine Impact on Immunotherapy-related Survival - by Justin Jee, @sawyerslabmskcc.bsky.social, Nikolaus Schultz, et al. doi.org/10.1158/2159... @mskcancercenter.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: The Landscape of Prostate Tumor Methylation - by Jaron Arbet, Takafumi Yamaguchi, Paul Boutros, and colleagues doi.org/10.1158/2159...

The June issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Yan Zhang, Songhua Wang, Weiwei Ma, Yuan Wang, et al. showing a role for tumor microtube expansion & neural synaptic pruning in GBM - Read that & more: aacrjournals.org/cancerdiscov...

Joan Massague giving the keynote at the EMBO Workshop on the Many Faces of Cancer Evolution - read his recent piece in Cancer Discovery @aacrjournals.bsky.social calling for an organ-informed precision oncology framework integrating site-imposed metastatic programs aacrjournals.org/cancerdiscov...

Couldn’t be happier to return to Rimini for the 3rd edition of the EMBO Workshop on the Many Faces of Cancer Evolution! Thanks @magnanilab.bsky.social @ciriellolab.bsky.social Céline Vallot, and Samra Turajlic for the invitation and congrats on another amazing meeting!

Now online in Cancer Discovery @aacrjournals.bsky.social: Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer - by Ahmed Elhossiny, @fertiglab.bsky.social, Eileen Carpenter, Timothy Frankel, Marina Pasca di Magliano, et al. doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Senescent-like Neutrophils Shape Angiogenic Immunosuppressive Niches in CRC Liver Metastasis - by Zhihang Chen, Xiaoxue Ren, Yifan Zhang, Youmei Kang, Ye Yang, Xiaoxing Li, Jianting Long, Lixia Xu, Ming Kuang, et al. doi.org/10.1158/2159...

Now online in Cancer Discovery AACR Journals: Mismatch Repair-Proficient Colorectal Cancer Can Evade Immune Surveillance through an Intrinsic Suppressive Program - by Chiara Cattaneo, Sharon Scardellato, @bardellilab.bsky.social et al. doi.org/10.1158/2159... IFOM

Now online in Cancer Discovery AACR Journals: A Spatial Atlas of Muscle-Invasive Bladder Cancer Reveals Lineage-Specific Vulnerabilities and Immune Architecture - by Kai Yu, Jianfeng Chen, Jianjun Gao, Linghua Wang, MD, PhD, et al. doi.org/10.1158/2159... @mdanderson.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: The Evolution of Polyclonal Competition in Aging Hematopoiesis - by @nvmp.bsky.social, Francesco Terenzi, and @benjaminwerner.bsky.social doi.org/10.1158/2159... @qmbci.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: [18F]RCCB6 PET/CT in Diagnosing ccRCC: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging - by Qianyun Wu, Shuxian An, Arturo Chiti, Gang Huang, Jianjun Liu, Weijun Wei, ad colleagues doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Development of CAR T cells Targeting a Surface RNA Binding Protein for the Treatment of Acute Leukemias - by Takeshi Fujino, Jennifer Lewis, @oawlab.bsky.social, Anthony Daniyan, et al. doi.org/10.1158/2159... @mskcancercenter.bsky.social

The May issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by @jeremynigri.bsky.social, Dave Tuveson, & colleagues showing myofibroblasts induce neuroplasticity to promote pancreatic inflammation & cancer progression. That & more: aacrjournals.org/cancerdiscov...

#AACR26 starts today! Can't wait to see everyone in San Diego! Follow www.aacrmeetingnews.... for updates during the meeting, including on all of the simultaneous publications coming out across the AACR Journals!