Learn how we used Droplet Paired-Tag to assess RNA expression and histone modifications in individual brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to AD #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Alzheimers u.epigenome.us/I8R4vBn2

Epigenetics Update - The CARM1 epigenetic enzyme inhibits cross-presenting dendritic cell function in cancer immunity u.epigenome.us/rm0K462P Xixi Zhang and Kai W. Wucherpfennig (danafarber.bsky.social) in science.org #Epigenetics #Immunity #Cancer #CARM1 #DendriticCells --- epigenometech.com

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements. #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics u.epigenome.us/I8R4vBn2

Epigenetics Update - Remodeling activity of ChAHP restricts transcription factor access to chromatin u.epigenome.us/Jm4I3LER aheljo.bsky.social and marcbuhler.bsky.social (fmiscience.bsky.social) in Molecular Cell #Epigenetics #Chromatin --- Empower your research at epigenometech.com

Epigenetics Update - ChAHP silences SINE retrotransposons by inhibiting TFIIIB recruitment u.epigenome.us/5LZrFw2r marcbuhler.bsky.social (fmiscience.bsky.social) in Molecular Cell #Epigenetics #Retrotransposons #Chromatin #SINE #TFIIB --- Discover the breakthrough at epigenometech.com

We offer an end-to-end Single-Cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks - our scientists run the workflow on your samples - from preparation to data analysis #Epigenetics #SingleCell #PairedTag u.epigenome.us/vyZjktjA

Epigenetics Update - Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia u.epigenome.us/JA5x3YpG Yotaro Ochi, Sören Lehmann, and Seishi Ogawa in @Nature #Epigenetics #Chromatin #AML #Cancer --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - Metabolically and epigenetically reprogrammed splenic TRNP1hiCD8+ T cells exacerbate liver fibrosis u.epigenome.us/ME2gY6KY Jin Hou (Naval Medical University, Shanghai) in natgenet.nature.com #Epigenetics #LiverFibrosis #Fibrosis --- Gain hi-res insights; epigenometech.com

New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks #Epigenetics #SingleCell #PairedTag #Multiomics Find out more at: u.epigenome.us/pCTHvQHK

Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service Our expert scientists run the entire workflow on your samples - from preparation to data analysis #Epigenetics #SingleCell #CUTandTag Find out more at: u.epigenome.us/Xz86EjGJ

New Epigenome Technologies Blog! u.epigenome.us/S3HTCftT "Single-Cell Chromatin and Transcriptomic Analyses of Tauopathy-affected Brains Reveal How Glial Cells Contribute" Based on a Nat Commun study from Jessica E. Rexach #Epigenetics #Chromatin #SingleCell #Tauopathies #Blog #Glia

Epigenetics Update - Promoter reinforcement supports transcriptional resilience in drug-resistant cancer u.epigenome.us/jLJOzb0p Vasumathi Kameswaran/Bence Daniel (Genentech Inc.) in natsmb.nature.com #Epigenetics #Cancer #Promoters --- Hi-res insights without cell sorting; epigenometech.com

Epigenetics Review - Evolution and development of innate immune memory u.epigenome.us/sjLdZB2y Maziar Divangahi and Eva Kaufmann (mcgill.ca) in Science Immunology #Epigenetics #Immunity #Evolution --- Perfect for cancer, immunology, and aging research; epigenometech.com

New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit Fully compatible with 10x Chromium® (ATAC), Fluent PiP-seq®, or BD Rhapsody #Epigenetics #SingleCell #CUTandTag Find out more at: u.epigenome.us/NYjSGQao

Learn more about single-cell epigenetic profiling by downloading our guide to single-cell CUT&Tag and Paired-Tag, which provides comparisons to other methods and bioinformatic insight #Epigenetics #Multiomics #CUTandTag #10XGgenomics #ChIPSeq #SingleCell #PairedTag u.epigenome.us/mHSAqLpl

Epigenetics Update - Genome-wide rotational and translational phasing of nucleosomes with human transcription factors u.epigenome.us/X19eVeDK B. Franklin Pugh (cornelluniversity.bsky.social) in Mol Cell #Epigenetics #Nucelosomes #Phasing --- Empower your research at epigenometech.com

New Epigenome Technologies Blog! u.epigenome.us/w23Xazct "Perturb-multiome Identifies Aging and Senescence-Associated lncRNAs as Therapeutic Targets" Based on a Nature Aging study from researchers led by Jing-Dong Jackie Han #Epigenetics #Blog #Aging #PerturbSeq #lncRNAs #Senescence

Epigenetics Update - Replication-stress-induced chromatin loops protect fork stability u.epigenome.us/tbH5bRGB Vincent Gaggioli/Kaustav Sengupta and nitikataneja.bsky.social (erasmusmc.bsky.social) in nature.com #Epigenetics #Chromatin #ChromatinLooping --- epigenometech.com

Epigenetics Update - Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning u.epigenome.us/cBO1wGSU ehannezo.bsky.social and priscaliberali.bsky.social in Cell #Epigenetics #Chromatin --- Gain deeper insights with epigenometech.com

Our expansion of single-cell epigenetics assays continues! The Epigenome Technologies scCUT&Tag assay is now compatible with the BD Rhapsody platform #Epigenetics #BDrhapsody #CUTandTag #Chromatin #Multiomics #Singlecell #CUTandRUN #ChIPseq #ATACseq Learn more here: u.epigenome.us/NYjSGQao

New Epigenome Technologies Blog! u.epigenome.us/PKM277oz Pronuclear Competition and Volume Regulate Histone Modification Patterning in Mouse Zygotes to Influence Developmental Potential Based on a Nature study from Hirohisa Kyogoku and Tomoya S. Kitajima #Epigenetics #Blogs #Chromatin

We have recently expanded our single-cell epigenetics assays! Our Emulsion scCUT&Tag assay is now compatible with the Illumina PIP-seq platform #SingleCell #EpigenomeTech #PairedTag #Multiomics #Epigenetics #scCUTandTag #PIPseq Learn more here: u.epigenome.us/NYjSGQao

Epigenetics Update - Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders u.epigenome.us/fqLowHgX Xin He and Jubao Duan (University of Chicago) in science.org #Epigenetics #Multiomics #SingleCell --- Gain deeper insights; epigenometech.com

Paired-Tag in the Wild! - Xist expression in male Peromyscus leucopus is associated with restricted chromatin repression and incomplete X-to-autosome dosage compensation u.epigenome.us/zppvMC1r #Epigenetics #PairedTag #EpigenomeTech --- High-res insights without cell sorting; epigenometech.com

Download our poster to learn how we applied Droplet Paired-Tag to Alzheimer's disease post-mortem brain tissue to reveal specific cellular changes and potential therapeutic targets #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers u.epigenome.us/I8R4vBn2

Epigenetics Review - Lysine methylation as a bidirectional switch u.epigenome.us/1Z1aeIxt Bao Quang Gia Le and Monika Raj (emoryuniversity.bsky.social) and Cell Chem Biol #Epigenetics #Reviews #LysineMethylation --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - Cis and trans regulatory mechanisms of extrachromosomal DNA segregation u.epigenome.us/uxSrvmrh Sihan Wu and Yoon Jung Kim (University of Texas Southwestern Medical Center) in natcellbio.nature.com #Epigenetics #ExtrachromosomalDNA --- epigenometech.com

Epigenetics Update - Fasting primes small intestinal regeneration after damage via a microbiome–metabolite–chromatin axis u.epigenome.us/fKhbQYI7 Kunal Rai and Helen Piwnica-Worms (mdanderson.bsky.social) in pnas.org #Epigenetics #Chromatin #Microbiome #Regeneration --- epigenometech.com

Epigenetics Update - An emergent disease-associated motor neuron state precedes cell death in ALS u.epigenome.us/TW2HNUMs Olivia Gautier/Jacob A. Blum & Aaron D. Gitler (Stanford University) in Cell #Epigenetics #ALS #Chromatin --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis u.epigenome.us/YrcgiOdA Ömer H. Yilmaz (mit.edu) and Norihiro Goto (weillcornell.bsky.social) in Cell Stem Cell #Epigenetics #Metastasis #ColoRectalCancer --- Empower your research at epigenometech.com