Irina Bezsonova
@irinabezsonova
🇺🇦🇨🇦🇺🇸Associate professor UCONN Health. NMR, structural biology, ubiquitination, sumoylation, DUBs, sciArt
This is the third of the 3-piece art project of de novo enzymes I’ve recently finished.
This is a second of the 3-piece series of de novo enzymes I was working on.
New drawing! A domain we nicknamed pixel. www.biorxiv.org/content/10.6...
Excited to share a new preprint where we pinpoint multivalent interactions between USP7 and MAGEL2 and show that they are disrupted by pathogenic USP7 variants. Great work by Emilie Korchak in collaboration with Bing Hao at UConn and Klementina Fon Tacer at Texas Tech www.biorxiv.org/content/10.6...
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 23/31 Prompt FIREFLY Pdb: 2D1R Luciferase: firefly enzyme catalyzes a light-producing reaction that makes fireflies glow. Next: ROWDY Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 22/31 Prompt BUTTON Pdb: 1ZXK Like tiny buttons, cell adhesion proteins such as this Cadherin-8 hold cells together to form tissues. Next: FIREFLY Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 21/31 Prompt BLAST Pdb: 1GVR An oxidoreductase enzyme PETN from bacterium Enterobacter cloacae can bind and degrade high explosives such as TNT 💥 Next: BUTTON Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 20/31 Prompt RIVALS Pdb: 8V27 & 8G6S Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them. Next: BLAST Suggestions?
I’ve been traveling to fun places and meeting awesome people at the IPS meeting in Brazil but falling behind on my inktober artwork. Here is the preview for the prompt RIVAL. Guess what it is!
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 19/31 Prompt ARCTIC Pdb: 3UYU Meet ice-binding protein (LeIBP) from Arctic yeast that acts like antifreeze! Next: RIVALS Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 18/31 Prompt DEAL Pdb: 9MKL A handshaking dimer of a tRNA deacylase strikes a deal to keep translation faithful. Next: ARCTIC Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 17/31 Prompt ORNATE Pdb: 9MME For the Escher fans! An ornate molecular cage made entirely of RNA. Next: DEAL Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 16/31 Prompt BLUNDER Pdb: 8G5J DNA mismatch blunder being fixed by mitochondrial DNA polymerase γ. Next: ORNATE Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 15/31 Prompt RAGGED Pdb: 2W8M A rugged nuclease D212 from a virus that preys on archaea in the scalding waters of hot springs. Next: BLUNDER Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 14/31 Prompt TRUNK Pdb: 1FNY Lectin. This old tree house is made of a lectin protein found in the bark of a black locust tree, Robinia pseudoacacia. Next: RAGGED Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 13 Prompt DRINK Pdb: 7BTW A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer. Cheers! Next: TRUNK Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 12 Prompt SHREDDED Pdb: 6TUB β-Endorphin. The protein precursor POMC is shredded by proteases into multiple peptide hormones, including β-endorphin. Next: DRINK Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 11 Prompt STING Pdb: 6MZT Scorpion venom protein Urotoxin. Next:SHREDDED Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 10 Prompt SWEEP Pdb: 7NAP Proteasome: the cleanup machine. It breaks down damaged or unneeded proteins, keeping the cell neat and efficient. Next: STiNG Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 9 Prompt HEAVY Pdb: 4DL6 Heavy metal therapy. Platinum-based cancer drug cisplatin damages DNA but DNA polymerase eta manages to copy it past the lesion. Next: SWEEP Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 8 Prompt RECKLESS Pdb: 5TZO A reckless surge. Two molecules of fentanyl engulfed by its computationally designed binder Fen49* Next: HEAVY Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 7 Prompt STARFISH Pdb: 6KG7 Starfish relies on sensory information. This is Piezo 2 - mechanically activated ion channel responsible for the sense of touch. Next: RECKLESS Suggestions?
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 6 Prompt PIERCE Pdb: 8HO3 8HQO 8HQZ 8HRE 8HRG Structure of a bacteriophage DT57C that carries a special piercing tip to attack bacteria. Next: STARFISH Suggestions?