This case report describes a 60-year-old woman presenting with sudden loss of muscle tone with preserved consciousness and severe daytime sleepiness. ja.ma/4fMpmgB

In #PrimaryProgressiveAphasia, automated #SpeechAnalysis of a brief picture description task distinguished nonfluent, logopenic, and semantic variants and produced interpretable speech profiles. ja.ma/4w4A2xg

In #MultipleSclerosis, higher serum glial fibrillary acidic protein was associated with greater risk of progression independent of relapse activity, while neurofilament light chain was more closely associated with relapse risk. ja.ma/3TTRpU9

JAMA Neurology EIC S. Andrew Josephson, MD, selected this as his 2025 Editor's Choice: Clinical Trial of the Year for its important findings on relapse risk after discontinuing disease-modifying therapy in stable MS. 🔗 Read the Editorial: ja.ma/3S5wbSN

In a RCT published in JAMA Neurology, stopping first-line disease-modifying therapy led to more inflammatory disease activity vs continuing treatment for patients with stable #MultipleSclerosis (MS) for at least 5 years. ja.ma/3TOFkzx

Patients with functional #neurological disorder exhibit frequent psychiatric and neurological comorbidities, worse functional outcomes, higher health care use, and increased mortality compared with multiple sclerosis. ja.ma/3Rvrq4N

Limiting #ParkinsonDisease genetic testing to onset ≤50 years misses most carriers of pathogenic variants, including many eligible for gene-targeted therapies; broader, age-inclusive strategies may improve diagnostic yield. ja.ma/3RXVm9J

#Dementia prevalence increased over 2 decades in Mexico, Peru, and Puerto Rico, while rates remained stable in Cuba and the Dominican Republic, indicating an uneven and rising burden compared with high-income countries. ja.ma/4heaiuy

📑 JAMA Neurology #Review: Gene delivery platforms for #Glioblastoma include viral vectors, lipid nanoparticles, and nanocarriers, with oncolytic HSV gaining approval and new nonviral approaches entering early clinical trials in #NeuroOncology. ja.ma/4bomipD

Presented at #AAIC26 from @JAMA.com: #Amyloid clearance was most efficient in gyral crests, not sulcal depths, and correlated locally with reduced #tau #pathology and #neurodegeneration after aducanumab therapy in #AlzheimerDisease. ja.ma/3SYsxtZ

This case report describes a 71-year-old woman presenting with altered speech, gait difficulties, and hearing loss diagnosed with infratentorial superficial siderosis and a thoracic spinal cord cleft. ja.ma/4vKlSlR

Among veterans with prior #TraumaticBrainInjury, the plasma p-tau217/Aβ42 blood test for #AlzheimerDisease missed over half of brain amyloid-positive cases, indicating reduced diagnostic accuracy in this population. ja.ma/4wmWkLp

A patient with isolated peripheral nerve vasculitis developed reversible bilateral hypoglossal palsy and tongue atrophy, with resolution of bulbar symptoms following immunosuppressive therapy and reinnervation, a rare neurological outcome. ja.ma/3SVI9yg

💬 Perspective from JAMA: Monoclonal antibodies for #AlzheimerDisease clear brain amyloid-β and modestly slow cognitive decline in early stages, supporting a causal role but with clinically limited impact and risk for imaging abnormalities. ja.ma/4acXv7D

Among patients with familial or sporadic #Frontotemporal #Dementia, cerebrospinal fluid TMEM106B levels were lower with greater disease severity, progression, smaller brain volumes, and in carriers of the protective rs1990622 genotype. ja.ma/3SzcpPm

Machine learning analysis of patient-clinician conversations identified cognitive impairment with sensitivity 68% and specificity 64%, supporting passive speech-based screening in routine #PrimaryCare. ja.ma/3Q7JeCl

💬 Editorial: Routine clinical conversations in #PrimaryCare contain acoustic signals that machine learning models can use for passive cognitive impairment screening, but risks and potential biases must be evaluated before clinical adoption. ja.ma/4ePVXTw

Among adult #Ebola survivors, neurological symptoms such as memory loss, headaches, and depression remained common even 7 years post-infection, although most improved over time. ja.ma/4oycleA

Among adult #Ebola survivors, neurological symptoms such as memory loss, headaches, and depression remained common even 7 years post-infection, although most improved over time. ja.ma/3S9IQ72

Randomized clinical trial indicates middle meningeal artery embolization with n-butyl cyanoacrylate plus standard care reduced #SubduralHematoma recurrence and need for surgery vs standard care alone, with comparable safety profile. ja.ma/3S25VbG

Integrating genetic and pathological data increased diagnostic accuracy and identified ancestry-related differences in #ParkinsonDisease, supporting biologically informed diagnostic tools and future pathology-targeted therapeutic trials. ja.ma/4go5uSS

Integrating genetic and pathological data increased diagnostic accuracy and identified ancestry-related differences in #ParkinsonDisease, supporting biologically informed diagnostic tools and future pathology-targeted therapeutic trials. ja.ma/4e5sepx

Self-reported seizure durations in a large outpatient sample were often longer than laboratory-recorded values, with 90% of seizures lasting ≤4 minutes and substantial variation by seizure type and age group in #Epilepsy. ja.ma/3SvgmVa

A reperfusion-guided systolic blood pressure strategy improved functional outcomes and reduced hemorrhagic transformation for patients with acute #Stroke after endovascular therapy compared with guideline-recommended management. ja.ma/4fzbvfs

Among patients with acute ischemic #stroke due to large-vessel occlusion, standard-dose tenecteplase resulted in greater early reperfusion vs low-dose #alteplase, with comparable functional and safety outcomes. ja.ma/4vAqp9R

Performance of the FDA-cleared Lumipulse plasma #biomarker for amyloid pathology detection in #AlzheimerDisease varied by site and reagent lots, highlighting need for local assay verification and ongoing quality control. ja.ma/4xbynYr

An unusual congenital fusion of the left and right oculomotor nerves was identified in a child with complex #strabismus and ptosis, demonstrating a rare variant of cranial nerve dysgenesis on neuroimaging. ja.ma/4uVpalR

Peripheral neuropathy involves nerve damage that can cause numbness, tingling, pain, and mild muscle weakness in the legs and, sometimes, the arms. 📄 This JAMA Patient Page describes common symptoms, diagnosis, and treatment of peripheral neuropathy. ja.ma/4fqdbYx

A plasma staging model using #eMTBRtau243 and %p-tau217 demonstrated strong concordance with PET-based staging and clinical severity, supporting scalable, minimally invasive #AlzheimerDisease stratification. ja.ma/4fQNmRr

Neurological teleconsultations in rural German #PrimaryCare shifted referrals from ambulatory neurologists to other specialists and hospitals, but did not increase sole management within general practice. ja.ma/3PLgb79