Journal of Cell Science

@jcellsci

Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio

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Journal of Cell Science@jcellsci· 20d

In their Cell Science at a Glance article & poster, Pascal Höhne, Marie Hugenroth & Maria Bohnert @bohnertlab.bsky.social @uni-muenster.de highlight the multifunctionality & metabolic plasticity of the NVJ & its integration into the contact site network. journals.biologists.com/jcs/article/...

JCS poster: The nucleus–vacuole junction at a glance

Journal of Cell Science@jcellsci· 21d

Did you know that JCS publishes Short Reports? These articles (of up to 3000 words and 4 display items) report a significant finding that furthers our understanding of cell biology and provides the foundation for future studies. Find out more: journals.biologists.com/jcs/pages/re... #notforprofit

Journal of Cell Science@jcellsci· 21d

In this Review, Coral Zhou dissects the causes and consequences of genome size variation from the perspective of 3D genome organisation. journals.biologists.com/jcs/article/...

Cartoon speculating how changes in genome size are reflected at the level of single nucleosomes, TADs and subnuclear compartmentalisation. How do genomes adapt to changes in size? As genomes get bigger, their organization in 3D space dramatically shifts in ways we do not understand, likely requiring innovations at the molecular scale in order to maintain the same functions. Here we speculate on these changes at the level of single nucleosomes, TADs and subnuclear compartmentalization. (A) Based on previous work in Drosophila suggesting that heterochromatin machinery is titrated with increasing genome content (Dimitri and Pisano, 1989), we speculate that H3K9me3, an epigenetic mark associated with heterochromatin, will be less abundant on newly polyploid genomes. (B) Based on some evidence from axolotl (Schloissnig et al., 2021), we also hypothesize that TADs will generally scale with increasing genome size. (C) As genomes get bigger, nuclei also grow, resulting in a decrease in the ratio between nuclear surface and nuclear volume. Since the nuclear envelope is the source of many nuclear activities, including nuclear transport and communication with the endoplasmic reticulum, we speculate that major changes in nuclear shape and an increase in NPCs are required to accommodate a bigger genome. We also hypothesize that membraneless subnuclear compartments such as the nucleolus and heterochromatin domains will scale with genome size, and it will be interesting to measure how these changes affect ribosomal RNA production and gene silencing, respectively. Created in BioRender by Zhou, C., 2026. https://BioRender.com/6dz6avq. This figure was sublicensed under CC-BY 4.0 terms.

Journal of Cell Science@jcellsci· 21d

In this Opinion article, Peter Cook looks at the impact of clusters of RNA polymerases in linking DNA sequence and cell fate. journals.biologists.com/jcs/article/...

Waddington landscapes and transcriptional noise. Iconography adapted from Waddington (1957) and Urban and Johnston (2018). (A) Example landscape. Top, a stem cell (blue ball) differentiates as it rolls down through the landscape towards different valleys leading to different cell fates, presented here as fibroblast, myoblast or neuron. Bottom, according to the traditional model, individual lineage-specific genes are transcribed in different local minima. (B) Transcriptional noise is visualized as a transient ‘speed bump’ that diverts a fibroblast progenitor incorrectly down the myoblast path. (C) Increasing valley depth mitigates the effect of a speed bump. (D) Clusters will be in deeper minima, mitigating effects of transcriptional noise.

Journal of Cell Science@jcellsci· 22d

Haritha Prabha, Priscilla Phan and Daniel Levy review the emerging mechanisms regulating nuclear scaling and morphology. journals.biologists.com/jcs/article/...

Cartoon showing the regulators of nuclear size. (A)A variety of different biophysical forces are thought to act on the nucleus. Nucleocytoplasmic transport dictates the proteomes of the nucleoplasm and cytoplasm, which each give rise to different densities & osmotic pressures in these two compartments. Lower density in the nucleoplasm correlates with higher macromolecular diffusion rates. The NE is viscoelastic, which allows for NE growth while also producing membrane tension that can restrict growth. Weakening of the NE can cause membrane blebs that rupture & repair, also affecting nuclear size and shape. The overarching model is that the magnitude of these different biophysical forces and how they balance each other determine steady-state nuclear size in different cell types, developmental stages & organisms. However, in many instances, rigorous testing of this model awaits future investigation. (B) LINC complexes mediate interactions between the lamina & chromatin inside the nucleus & the actin & microtubule (MT) cytoskeletons in the cytoplasm, producing mechanical forces on the NE that affect nuclear size & shape. Additionally, force produced by intranuclear F-actin can drive nuclear growth and cytoplasmic vimentin filaments can resist NE deformation. (C) Other NE components that mechanically influence nuclear size include lamins and lamin–histone interactions, heterochromatin-binding proteins and lipid composition. (D) Chromatin is another mechanical effector that produces force on the NE. Chromatin forces are influenced interdependently by chromatin amount, histone modifications, chromatin compaction and stiffness, chromatin topology, chromatin-associated RNAs and protein condensates. H3K9ac, histone H3 acetylated at K9; H3K9me, histone H3 methylated at K9; H3K4me3, histone H3 trimethylated at K4; H3K27me3, histone H3 trimethylated at K27. Created in BioRender. Prabha, H., 2026. https://BioRender.com/5qy8f5g. This figure was sublicensed under CC-BY 4.0 terms.

Journal of Cell Science@jcellsci· 22d

In their Review, Caleb Embree @cembree.bsky.social & Katherine Borden summarise the similarities & differences of mRNA cap-binding chaperone proteins NCBP1–NCBP2 & eIF4E, describing their roles in mRNA processing in the nucleus & in translation. journals.biologists.com/jcs/article/...

Simplified summary of the journey of mRNA through cap-chaperone regulated RNA metabolism steps.

Journal of Cell Science@jcellsci· 23d

Also in Issue 13: - Research Highlights on a fungal virulence factor, ER-Golgi contact sites, ammonium transporters and neuron-epidermal attachment. - Opinion on the response to lysosomal damage - Primary cilium disassembly Review journals.biologists.com/jcs/issue/13...

Schematic showing the mechanisms contributing to cilia disassembly.

Journal of Cell Science@jcellsci· 23d

Issue 13 is complete Explore our Toc: journals.biologists.com/jcs/issue/13... On the cover: images of a C. elegans tail showing the localisation of AGEF-1 (gold, cyan & orange puncta) & RAB-35 (blue, green & yellow). See article from Bonacossa-Pereira et al. journals.biologists.com/jcs/article/...

JCS cover: Deconvolved confocal images showing a lateral view of the tail of the nematode Caenorhabditis elegans, highlighting the localisation of epidermal AGEF-1 (an orthologue of BIG2; gold, cyan and orange puncta in the top, middle and bottom images, respectively) and RAB-35 (cyan, green and yellow blobs and striated patterns in the top, middle and bottom images, respectively). AGEF-1 interacts with RAB-35 in the nematode epidermis to modulate the integrity of touch-sensing nerves embedded within the skin. See article by I. Bonacossa-Pereira et al. (jcs264565).

Journal of Cell Science@jcellsci· 23d

This article is associated with a field mapletree, planted in The Forest of Biologists. forest.biologists.com/landscape/

Tree no. 15506
Field maple (Acer campestre)

Sturdy broad-leaved deciduous tree, with a wide ecological range and natural distribution over most of Europe. Field maple has a light brown and flaky bark, with brown slender twigs that develop corky ridges with age. Its small, dark-green leaves have five lobes with rounded teeth, and fade to a rich golden-yellow or red before falling in autumn. A hermaphroditic species – its small, yellow-green, clustered flowers are pollinated by insects and develop into large, winged crimson fruits (samaras) that are dispersed by wind.

Field maple has a compact habit and grows in woods, scrub and hedgerows. While extremely tolerant to shade during the first decade, its light requirements are higher in seed-bearing years. It prefers warmer climates, but can also tolerate hard winters. Highly resistant to air pollution, the trees are widely planted in gardens and parks.

Journal of Cell Science@jcellsci· 23d

In their Review, Alexandra Edwards and Elizabeth Finn discuss how genome organisation underlies evolution and development. journals.biologists.com/jcs/article/...

Schematic showing evolutionary diversity in genome organisation

Journal of Cell Science@jcellsci· 27d

Read more about this research in our ‘First person’ interview with Hongzhe Peng: journals.biologists.com/jcs/article/...

Journal of Cell Science@jcellsci· 27d

Hongzhe Peng, Runyu Qiao, Bo Dong and colleagues discover that asymmetrical MTOCs drive posterior positioning of nuclei in Ciona notochord development. journals.biologists.com/jcs/article/...

Figure showing nuclear positioning and deformation in the Ciona notochord.

Journal of Cell Science@jcellsci· 27d

Deepash Kothiwal, Shalu Joseph and Shikha Laloraya find that cohesin sumoylation is required for repression of subtelomeric gene expression in Saccharomyces cerevisiae. journals.biologists.com/jcs/article/...

Figure showing telomere organization in cohesin sumoylation defective cells.

Journal of Cell Science@jcellsci· 28d

Ayse Mubine Turkmen, Katharine Ullman and colleagues discover that progerin-induced nuclear envelope remodeling is shaped by cell division and NUP153. journals.biologists.com/jcs/article/...

Figure showing that in interphase-arrested cells, progerin forms NE-associated foci that correspond to INM invaginations, whereas the ONM is unaltered.

Journal of Cell Science@jcellsci· 29d

Pleased to be a media partner for @embo.org @embl.org Symposium - DNA replication and genome maintenance: from basic biology to human health Abstract submission: 28 Jul 2026 Registration (On-site): 8 Sep 2026 Registration (Virtual): 13 Oct 2026 bit.ly/4qjhhnF #EESReplication

EMBO EMBL Symposium
DNA replication and genome maintenance: from basic biology to human health
20-23 October 2026
EMBL Heidelberg and Virtual

Journal of Cell Science@jcellsci· 29d

Luv Kishore Srivastava, Allen Ehrlicher and colleagues discover that progerin cross-linking stiffens the nucleus and impairs mechanosensation in Hutchinson–Gilford progeria syndrome. journals.biologists.com/jcs/article/... #nucleus #cellbiology

Figure showing nuclear wrinkling in progeria cells.

Journal of Cell Science@jcellsci· Jul 13

Chonkit Lio, Yuexia Wang, Paige Wilson, Howard Worman, Wakam Chang, Gregg Gundersen & team find that farnesylated prelamin A variants associated with premature aging disorders disrupt mobility of LINC complex proteins leading to defects in polarity. journals.biologists.com/jcs/article/...

Figure showing nuclear positioning and centrosome orientation in prelamin A-expressing cells treated with shRNA against SUN1 or the dynein inhibitor HPI-4.

Journal of Cell Science@jcellsci· Jul 10

Read more about this research in our ‘First person’ interview with Lily Schumacher: journals.biologists.com/jcs/article/...

Journal of Cell Science@jcellsci· Jul 10

Lily Schumacher, Iris Meier and colleagues find that Arabidopsis KASH domains are differentially required for distinct LINC complex roles in stomata, roots and pollen. journals.biologists.com/jcs/article/...

Figure showing that the SINE1 KASH domain is required for stomatal dynamics.

Journal of Cell Science@jcellsci· Jul 8

Working on stem cell biology? Our expert Academic Editor, Aryeh Warmflash (@warmflashlab.bsky.social), handles articles on this topic so send your article our way. It's FREE to publish in JCS and we're not-for-profit. Find out more: journals.biologists.com/jcs/pages/re... #stemcells #ISSCR2026

Journal of Cell Science@jcellsci· Jul 8

Yoichi Miyamoto, Hisato Saitoh and colleagues uncover a non-canonical function of importin α in genomic instability and cancer development. journals.biologists.com/jcs/article/...

Figure showing euchromatin localisation of importin α1 in micronuclei.

Journal of Cell Science@jcellsci· Jul 7

This article is associated with an alder tree, planted in The Forest of Biologists. forest.biologists.com/landscape/

Tree no. 16689
Alder (Alnus glutinosa)
Alder
Adaptive and fast-growing deciduous tree found in moist ground across most of Europe. It has a dark, fissured bark and long, dark green, leathery leaves with serrated edges. A monoecious species with pendulous male catkins, the green, oval-shaped female catkins turn into small brown cones after wind pollination, with seeds being dispersed by wind and water.

Alder prefers deep soils with a high water table and is resistant to waterlogging. Its roots prevent soil erosion, contributing to flood control and the stabilisation of riverbanks. It can grow in nutrient-poor soils owing to its association with nitrogen-fixing bacteria and can quickly colonise bare ground, making it a valuable pioneer species in improving soil conditions for other plants, particularly on reclamation sites. Alder woodlands host and shelter many forms of wildlife all year round, thus contributing to biodiversity.

Journal of Cell Science@jcellsci· Jul 7

Lucas Newton, Patrick Humbert and colleagues find that CDK9 interacts with a RanGTP–importin-β complex to regulate erythroid enucleation. journals.biologists.com/jcs/article/...

Summary of CDK9 co-immunoprecipitation mass spectrometry results in HUDEP-2 cells. (A) Venn diagram of identified interactors of CDK9 in undifferentiated (Day 0) & differentiated (Day 6) HUDEP-2 cells. Proteins were considered an interactor when present in all three replicates & ≥3 fold enriched compared to the IgG controls. (B) STRING analysis of the 13 common proteins identified in both undifferentiated (Day 0) and differentiated (Day 6) HUDEP-2 cells. STRING analysis was performed using medium confidence (0.4) for interaction score. Aqua lines represent known interactions from curated databases; purple lines represent experimentally determined known interactors. Green, red and blue lines represent predicted interactors; yellow lines represent text mining identification and black lines represent known co-expression. (C) Venn diagram of identified interactors of CDK9 overexpression, CDK9-T186A and CDK9-D168N lines in differentiated (Day 6) HUDEP-2 cells. Proteins were considered an interactor when present in all three replicates and ≥3 fold enriched compared to the IgG controls. See Table S2 for a complete list of identified proteins. (D) STRING analysis of the nine common proteins identified in all three HUDEP-2 CDK9 overexpression cell lines. STRING analysis was performed using medium confidence (0.4) for interaction score. Aqua lines represent known interactions from curated databases; purple lines represent experimentally determined known interactors. Green, red and blue lines represent predicted interactors; yellow lines represent text mining identification and black lines represent known co-expression. (E) Heatmaps of clusters 1–4 described in Fig. S5. Proteins identified in each cluster were compared to the average abundance found in CDK9, CDK9-T186A and CDK9-D168N overexpression HUDEP-2 cell lines. Top biological processes (GO) and molecular functions (GO) identified in STRING are listed below for each cluster (strength >2, false discovery P<0.001).

Journal of Cell Science@jcellsci· Jul 7

Read more about this research in our ‘First person’ interview with Pallavi Deolal @pallavideolal.bsky.social: journals.biologists.com/jcs/article/...

Journal of Cell Science@jcellsci· Jul 7

Pallavi Deolal @pallavideolal.bsky.social, Krishnaveni Mishra and colleagues discover that Uip4 governs nuclear shape by modulating the Saccharomyces cerevisiae lipidome. journals.biologists.com/jcs/article/...

Figure showing that uip4Δ cells have increased lipid droplets as compared to the wild-type cells.

Journal of Cell Science@jcellsci· Jul 6

Read more about this research in our ‘First person’ interview with Adesh Vaidya: journals.biologists.com/jcs/article/...

Journal of Cell Science@jcellsci· Jul 6

Adesh Vaidya, Alexander Fezovich and Sally Wheatley dissect the relationship between nuclear survivin and the PRC2 complex and its impact on H3K27me3-directed transcriptional repression. journals.biologists.com/jcs/article/...

Figure showing that survivin is nuclear in hypoxic cells.

Journal of Cell Science@jcellsci· Jul 6

Samantha Bunner, Katie Huang, Anish Shah, Schuyler Figueroa, Andrew Stephens @andrewdstephens.bsky.social and colleagues investigate how cell cycle-based changes in nuclear and actin mechanics impact nuclear integrity and shape. #CellBio #nucleus journals.biologists.com/jcs/article/...

Journal of Cell Science@jcellsci· Jul 3

Pei-Shang Wu, Todd Fallesen and Frank Uhlmann @crick.ac.uk use super-resolution microscopy and semi-automated measurements to dissect chromosome size determinants in fission yeast. journals.biologists.com/jcs/article/... #CellBio #nucleus

Figure showing chromosome size in larger cells

Journal of Cell Science@jcellsci· Jul 2

David Kohlhause, Ralph Kehlenbach and colleagues identify TMEM209 as an integral component of the nuclear pore complex which cooperates with Nup210 in cell cycle progression and cell proliferation. journals.biologists.com/jcs/article/... #CellBio #nucleus