Journal of Clinical Investigation
@jci
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
Winners of Lasker Foundation Video Contest announced: www.jci.org/articles/vie...
Featuring a behind-the-scenes glimpse at co-first author Michelle Hua collecting data. Music by Bensound.com/royalty-free-music, License code: Z9ZQJVCTOJK96LG2 Artist: : Benjamin Tissot
Linking neuronal hyperactivity to epilepsy & cognitive impairment: doi.org/10.1172/JCI1... This issue’s cover features work by Guang Yang & team @ucalgarymed.bsky.social on pathogenic variants in the RNA-binding protein CELF2 that are associated with at least two neurodevelopmental disorders.
Mechanoreceptor Plexin D1 regulates lymphatic valve morphogenesis and lymphedema pathogenesis: doi.org/10.1172/JCI1...
How does mechanical frictional force guide lymphatic valve development? doi.org/10.1172/JCI1... Ellie Tzima & team report on mechanoreceptor plexin D1 in the regulation of lymphatic valve morphogenesis and lymphedema. @petrovalab.bsky.social
Deficiency of muscular dystrophy-related gene JAG2 causes NOTCH signaling dysfunction in muscle stem cells: doi.org/10.1172/JCI1...
Attention researchers in muscle biology, stem cell biology, neuromuscular disorders, and Notch signaling👇 doi.org/10.1172/JCI1... Atsushi Asakura & team report that deficiency of the muscular dystrophy–related gene JAG2 causes NOTCH signaling dysfunction in muscle stem cells
17β-Estradiol limits pathological microtubule stabilization and improves cardiac function in pulmonary artery–banded rats: doi.org/10.1172/JCI2...
New information on how estrogen impacts the heart: doi.org/10.1172/JCI2... Using iPCs and two rodent models, Kurt W. Prins @kurtprins.bsky.social @the-asci.org & team find estrogen exerts cardioprotective effects by regulating microtubules.
Spotlight: Offering a potential new therapy for aggressive, treatment-resistant pediatric brain tumors: doi.org/10.1172/JCI1... Rongze Olivia Lu & team @neurosurgucsf.bsky.social find targeting protein phosphatase 2A induces tumor cell senescence & boosts immune response in medulloblastoma models.
Anti-IL6R therapy diminished AtpTreg cell and improves clinical outcomes. doi.org/10.1172/JCI2...
From this week: Can we alleviate immune checkpoint inhibitor–induced inflammatory arthritis while maintaining anti-tumor immunity? doi.org/10.1172/JCI2... Ma et al. discover a Treg cell subset that causes ICI-IA—in which IL-6R block offers a safe treatment without compromising anti-tumor immunity.
Nephrin autoimmunity: signal, noise, and a path to clarity: doi.org/10.1172/JCI2... Dhruti P. Chen and Ronald J. Falk provide a Commentary on Pecoraro et al. doi.org/10.1172/JCI2...
Ammonia in the Crosshairs: Microbial targets for metabolic dysfunction-associated steatohepatitis prevention: doi.org/10.1172/JCI2... Vanessa A. Leone and Arion Kennedy comment on Qu et al. doi.org/10.1172/JCI2...
Checkpoint inhibitors create rogue regulatory T cells: doi.org/10.1172/JCI2... Smriti Parashar and Klaus Ley comment on Ma et al. doi.org/10.1172/JCI2...
Anti-nephrin antibodies are not enriched in patients with primary and post-transplant recurrent podocytopathies: doi.org/10.1172/JCI2...
See the accompanying Commentary by Dhruti P. Chen and Ronald J. Falk: www.jci.org/articles/vie...
Challenging the view that anti-nephrin antibodies are a primary driver of podocytopathies: doi.org/10.1172/JCI2... Ariela Benigni & team report anti-nephrin antibodies are not enriched in patients with primary and post-transplant recurrent podocytopathies.
Read the associated Commentary by Vanessa A. Leone & Arion Kennedy: www.jci.org/articles/vie...
Metabolic dysfunction-associated steatohepatitis exacerbated by Clostridium perfringens-derived ammonia is attenuated by tripeptide DT-109: doi.org/10.1172/JCI2...
Targeting gut microbiota offers a strategy for MASH doi.org/10.1172/JCI2... Y. Eugene Chen @the_asci.org & team show an ammonia-producing bacterium weakens the gut barrier & over activates liver immune cells in MASH models. And DT-109 lowered ammonia & improved disease
Pulmonary arterial hypertension induces a metabolic and inflammatory hepatopathy: doi.org/10.1172/JCI2...
The 1st cellular and molecular analysis of the liver in pulmonary arterial hypertension (human tissue): doi.org/10.1172/JCI2... @kurtprins.bsky.social & team find PAH reshapes liver metabolism, inflammation & fibrosis in a manner distinct from NASH & Fontan-associated liver disease. @the-asci.org
Behind the scenes: Cell-free DNA extraction by research associate Hailu Fu and computational analysis of cf DNA fragmentation led by first author Ravi Bandaru, a medical student.
Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer: doi.org/10.1172/JCI1...
Predicting immunotherapy response in head and neck cancer: doi.org/10.1172/JCI1... Yaping Liu & team developed rMDS (regional motif diversity score), representing a biologically meaningful, clinically actionable biomarker for the immunotherapy response in HNSCC.
Proposing a new approach for aggressive, treatment-resistant pediatric brain tumors. Rongze Olivia Lu & team @neurosurgucsf.bsky.social target protein phosphatase 2A (PP2A) to induce tumor cell senescence and boost immune response in medulloblastoma models: doi.org/10.1172/JCI1... #medulloblastoma
Another side to a biological pacemaker of the heart: doi.org/10.1172/JCI1... Wang et al. find long-term TBX18 expression in rodents causes fibrosis and fails to induce pacemaker activity, while Hcn2 reliably generates pacing, making it a candidate for biological pacemakers.
Offering a potential new therapy for aggressive, treatment-resistant pediatric brain tumors: doi.org/10.1172/JCI1... Rongze Olivia Lu & team @neurosurgucsf.bsky.social find targeting protein phosphatase 2A (PP2A) induces tumor cell senescence and boosts immune response in medulloblastoma models.
Spotlight: A shared atherogenic mechanism across multiple non-LDL lipoproteins that contribute to residual cardiovascular risk: doi.org/10.1172/JCI1... Cabodevilla et al. identify a region in APOB critical for atherosclerosis development & generate a peptide that reduces atherosclerosis in mice.