🆕 in JMCC: Enhancing mitochondrial SK channels restores mitochondrial Ca²⁺ and redox homeostasis, suppresses pro-arrhythmic Ca²⁺ release, and rescues Ca²⁺ cycling in HFpEF cardiomyocytes, highlighting a promising antiarrhythmic strategy⚡️ www.jmcc-online.com/article/S002...

🚨 New in JMCC: This review highlights how single-cell multi-omics and computational approaches are transforming our understanding of cardiac aging, revealing cell type-specific remodeling and new therapeutic targets in aging hearts 💊 ❤️‍🩹 www.jmcc-online.com/article/S002...

🆕 in JMCC: L-menthol protects cardiomyocytes from lipid overload by preserving TRPM8 signaling, mitochondrial Ca²⁺ homeostasis, and mitochondrial function. Stabilizing TRPM8 may represent a new therapeutic strategy for metabolic heart disease🫀 www.jmcc-online.com/article/S002...

🚨 New in JMCC: Integrated single-cell multi-omics identifies fibroblast-like smooth muscle cells as a progenitor-like population driving aortic aneurysm progression through a KAT5-mediated metabolism-epigenetic axis regulating phenotypic switching 🧬 www.jmcc-online.com/article/S002...

🆕 in JMCC: A CRISPR-generated non-phosphorylatable phospholamban (PLB) mouse model reveals that PLB phosphorylation is essential for a full adrenergic response, preserving SR Ca²⁺ load, Ca²⁺ reuptake, and excitation-contraction coupling ⚡️ www.jmcc-online.com/article/S002...

🆕in JMCC: Peroxisomes are critical regulators of lipid metabolism, redox balance, & cellular homeostasis, yet their roles in the 🫀 remain underexplored. This review by Rungreang et al highlights emerging evidence linking peroxisomes to cardiac health and disease www.jmcc-online.com/article/S002...

🆕 in JMCC: Roman et al. uncover a mechanism underlying sex differences in cardiac ischemia/reperfusion injury. Increased S-nitrosylation of MCU in female hearts limits mitochondrial calcium accumulation during ischemia♀️♂️🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: Zhou et al. reveal strikingly similar metabolic signatures in human end-stage ischemic and nonischemic cardiomyopathy. Both exhibit altered amino acid metabolism, oxidative stress, purine breakdown, and depleted glutathione ⚡️🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: Liu et al. identify hematopoietic PI3Kγ as a key driver of abdominal aortic aneurysm progression. PI3Kγ promotes macrophage trafficking, aortic inflammation, and aneurysm growth, highlighting a potential therapeutic target 🎯 www.jmcc-online.com/article/S002...

🚨 New in JMCC: Jiang et al. identify the CYLD-RIPK1 axis as a key regulator of DNA damage and pathological cardiac hypertrophy. Targeting CYLD attenuated remodeling and preserved cardiac function in pressure-overloaded hearts 🎯 www.jmcc-online.com/article/S002...

🆕 in JMCC: Bacchini et al. show that aging and cardiomyopathy jointly reshape unfolded protein response pathways, highlighting defective proteostasis as a key contributor to myocardial dysfunction and heart failure 👴🏼👵🏼🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: PERK is a key regulator of the unfolded protein response, but its activation mechanisms remain unclear. Georgoula et al. identify stable PERK assembly states that persist during ER stress, suggesting new modes of regulation 👏🏼 www.jmcc-online.com/article/S002...

🆕 in JMCC Special Issue on The Diabetic Heart: Kanki and Young review the role of mineralocorticoid receptor signaling in diabetic cardiomyopathy and its potential as a therapeutic target to reduce cardiovascular risk 🫀 💪🏼 www.jmcc-online.com/article/S002...

🚨 New in JMCC: Zheng et al. identify DPP4 as a key regulator of endothelial ferroptosis in atherosclerosis. DPP4 promotes ferritinophagy, endothelial dysfunction, and plaque progression, highlighting a potential therapeutic target 🎯 www.jmcc-online.com/article/S002...

🚨 New in JMCC: Zhang et al. identify LARP7 as a regulator of cardiomyocyte proliferation and cardiac regeneration. LARP7 promotes G2/M transition and, with CDK4/CCND1, improves heart repair after injury ❤️‍🩹 www.jmcc-online.com/article/S002...

🆕in JMCC: Single-cell analyses reveal activated, dysfunctional cardiac T cells in dilated cardiomyopathy. Distinct CD4⁺ subsets, including tissue-resident memory T cells, show pro-fibrotic signaling linked to ERα activity and systolic dysfunction 🫀 www.jmcc-online.com/article/S002...

🆕in JMCC: AAV-mediated delivery of WT TNNI3 rescues thin filament-mediated dilated cardiomyopathy in a murine model of Tnni3 mutation. Gene supplementation restored troponin function and prevented the development of heart failure🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: Transcription initiation factor TIF-1A regulates vascular smooth muscle contraction and blood pressure by controlling ribosome biogenesis. Smooth muscle-specific Tif-1a loss reduces vasoconstriction and protects against Ang II-induced hypertension 💪🏼 www.jmcc-online.com/article/S002...

🆕 in JMCC: Atrial t-tubules undergo dynamic postnatal remodeling as Ca²⁺ handling matures. Despite structural changes and reduced ICa-L and SR Ca²⁺, decreased Ca²⁺ buffering helps preserve Ca²⁺ transients during development 🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: JTC801 suppresses HIF-1α–mediated CA9 activation to trigger alkaliptosis in vascular smooth muscle cells, restoring intracellular pH homeostasis and reducing aortic dissection formation in a mouse model 👏🏼 www.jmcc-online.com/article/S002...

Check out this 🆕 article in JMCC: METTL3-driven m6A modification enhances LGMN translation via YTHDF1, promoting macrophage ferroptosis and accelerating atherosclerosis. Targeting this pathway may offer new therapeutic opportunities 🫀 www.jmcc-online.com/article/S002...

🆕 in JMCC: Genetically encoded biosensors reveal real-time redox dynamics in cytosol and mitochondria of live cells. The study shows metabolic pathways shape compartmental redox balance and that mitochondrial redox status is highly sensitive to stress ⚡️ www.jmcc-online.com/article/S002...

🆕 in JMCC: Acetylation of ACTC1 at K326 and K328 weakens actin-tropomyosin interactions and reduces thin filament inhibition under low Ca²⁺, promoting contractile activation. New work reveals how actin modification can tune cardiac thin filament regulation 🫀 🦾 www.jmcc-online.com/article/S002...

🚨 🆕 in JMCC: Circadian rhythms are essential for cardiovascular health, yet hypertension & heart disease can disrupt the molecular clock itself. This review explores the bidirectional relationship between circadian biology, blood pressure, and CV disease 🕰️ 🫀 www.jmcc-online.com/article/S002...

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🚨🆕in JMCC Special Section: The Diabetic Heart This review highlights the angiotensin type 2 receptor (AT2R) as a therapeutic target in diabetic cardiomyopathy. Preclinical data show AT2R agonists ⬇️ inflammation & fibrosis & improve cardiac function. www.jmcc-online.com/article/S002...

🚨 🆕in JMCC Special Section: Better Together - Exp+comp models in cardiac remodeling. This study shows lactation prolongs postpartum heart growth in mice, while non-lactation reverses hypertrophy. Modeling reveals complementary mechanical and biological drivers. www.jmcc-online.com/article/S002...

🆕in JMCC: IGF-1 accelerates cardiac pacemaking by increasing cell surface expression of HCN4 channels in the sinoatrial node. This effect depends on Rab11-mediated endocytic recycling, offering a mechanistic explanation for IGF1-associated tachycardia. www.jmcc-online.com/article/S002...

🆕in JMCC: In silico modeling reveals how stretch-activated ion channels drive ventricular re-entry. Arrhythmias emerge from interactions between stretch-induced depolarization and repolarization, shaped by stimulus timing, spatial gradients, & tissue properties. www.jmcc-online.com/article/S002...

🆕in JMCC: Fibroblast-specific USP7 drives post-MI cardiac fibrosis by stabilizing KLF7 and activating pro-fibrotic GATA3 signaling. Genetic deletion of USP7 limits myofibroblast activation, improves cardiac function, and mitigates adverse remodeling. www.jmcc-online.com/article/S002...