'Uncertainty should be the rule, not the exception: Integrating fibre orientation variability in cardiac electrophysiology modelling' Ovais Ahmed Jaffery & Caroline Helen Roney from @qmul.bsky.social offer this #Perspective on Tanner et al. (2026)✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Martin Dvoulety & Michal Sitina present a #modelling study into the haemodynamic-energetic mechanism of sudden cardiac death in severe aortic #stenosis 🫀 ⚙️ Read the #research👇️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Lindsay C. R. Tanner from @utah.edu and colleagues conducted #uncertainty quantification via polynomial chaos expansion of #myocardial fibre orientation and cardiac activation patterns 🫀 ✍️ Read the #research👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Dennis Ogiermann from @ruhr-uni-bochum.de and colleagues used a simple voltage-modulated Markov chain #model for the #Piezo1 ion channel to investigate #electromechanical pacing 🧫 ⚡️ Read the study here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Ludovica Cestariolo and colleagues provide a mathematical #model of the zebrafish ventricular #cardiomyocyte action potential and calcium transient🫀 ⚙️ Ready the article👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Karin C. Smits from @carimmaastricht.bsky.social and colleagues provide insights from electrocardiographic #imaging as they investigated the influence of delayed ventricular activation on cardiac #repolarization 📸 🫀 Read the #research 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Stefan Meier from @carimmaastricht.bsky.social et al. employed #computational modelling of the pro- and antiarrhythmic effects of atrial high rate-dependent trafficking of small-conductance calcium-activated potassium channels 🔬 ⚙️ Read the study👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'There are more things in heaven and Earth than we dream of in our physiology' Read this #LettertotheEditor by Denis Noble from @oxforddpag.bsky.social in response to the Perspective article by Maltsev et al. (2025) ✍️ ✉️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Sophia Bäck from @liu.se and colleagues investigated virtual left atrial appendage occlusion in paroxysmal #atrialfibrillation during sinus rhythm, and found that it predicts variable reductions in blood #stasis 🫀 🔎 Read the #research 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

When structure breaks, does electricity learn new routes? Aimée Obolari Durço and colleagues examine the recent article by Villar-Valero et al. (2026) ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

🎓️ EDITOR'S CHOICE🎓️ In a mouse model of cancer cachexia, Tsitkanou from @uarkansas.bsky.social et al. show the potential for exercise training not only to mitigate muscle loss, but also to reduce tumour burden. physoc.onlinelibrary.wiley.com/doi/10.1113/...

Julia H. Musgrave and colleagues observed that metabolite-sensitive cross-bridge models of human #atria reveal the impact of #diabetes on muscle #mechanoenergetics 🔎 💡 Read the study 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Cardiac remodelling in type 2 #diabetes: Pathophysiological mechanisms and opportunities for multiscale computational #modelling and #simulation' 💻️ 🫀 Read this review by Ambre Bertrand from @compscioxford.bsky.social and colleagues 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this study, Francesco Tripoli and colleagues assess the #cardiac function from micro-gravity to hyper-gravity conditions through a validated multiscale #modelling approach 🛰️ 💻️ Read the #research 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Our latest cover image was created by the Salman Group at @ox.ac.uk and depicts the #neurovascular interface as a dynamic connection between the brain and its vasculature 🖼️ 🧠 Read the latest issue here🔗 👇️ physoc.onlinelibrary.wiley.com/toc/14697793...

'The cardiac #pacemakers: A #paradigm of robustness in evolutionary biology' 📜 Read this review by Denis Noble from @oxforddpag.bsky.social 🔎 🫀 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Freddy L. Bueno-Palomeque of @unizar.es et al. offer insights from clinical and computational data based on their research into #electrophysiological characterization of pre-adolescents born with intrauterine growth restriction 🫀 💻️ Read the study👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Charles Stark and colleagues examine advances in cardiac devices and #bioelectronics augmented with #artificialintelligence in this #TopicalReview 🫀 💡 Read their work👇️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Cardiac digital twins: Modelling the arrhythmic substrate of chemotherapy' Radomir Chabiniok & Vlad G. Zaha provide this #TranslationalPerspective on the work by Villar-Valero et al. (2026) ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Jie Yang and Eric A. Sobie emphasize the utility of integrating computational (‘dry lab’) models with information from experimental (‘wet lab’) datasets in future iPSC-CM studies💻️ 🔬 Read the review👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Research by Vladimír Sobota and colleagues finds that the apicobasal dispersion of ventricular #repolarization in humans is associated with #age and affects arrhythmia vulnerability 🫀 🔬 Read the study👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

🎓️ EDITOR'S CHOICE 🎓️ Anuradha Kulathilaka et al. examined structural determinants of re-entrant drivers in atrial fibrillation, revealing insights from digital twins derived from 3D micrometre-resolution imaging of human heart 🫀 💻️ Read the study👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Caterina Vidal Horrach from qmul.bsky.social and colleagues explore how the combination of #experimental and #computational techniques can enhance our understanding of the arrhythmogenic effects of fibrosis💻️ 💉 Read the #TopicalReview👇️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

'From microgravity to hypergravity: Perspectives on circulatory adaptation through multiscale modelling' Dario Collia and co-authors offer this perspective on the work of Tripoli et al. (2026) ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this study, Moritz Linder from @kit.edu and colleagues observed that sympathetic stimulation can compensate for hypocalcaemia-induced #bradycardia in human and rabbit sinoatrial node cells 🔎 🫀 Read the #research 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'From molecule to bedside and back: the integration of computational and experimental physiology in the digital age' In this opening Editorial, Viviane Timmermann & Axel Loewe introduce the articles included in the latest special issue ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Remembering Professor Alistair J. Gunn (1958–2026) Explore this virtual collection of his influential contributions to JPhysiol, celebrating a remarkable scientific legacy. Professor Gunn was awarded the 2025 Prime Minister's Science Prize with Joanne Davidson and Laura Bennet. 🔗 buff.ly/B9QSSPP

Latest issue now live! 🎉 🫀 This special issue explores 'Integrating experimental and mathematical approaches to advance cardiac physiology research' 🎓️ Organised by Dr Axel Loewe of @kit.edu and Dr Viviane Timmermann of @uni-freiburg.de physoc.onlinelibrary.wiley.com/toc/14697793...

Martin G. Frasch presents this #Opinion piece, 'Causal thinking in physiology: A search for vertically organizing principles' 💭 Available here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Jimena Siles and colleagues present an integrated platform for 2-D and 3-D optical and electrical #mapping of #arrhythmias in Langendorff-perfused rabbit hearts 🫀 ⚡️ Read the article 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...