Read this paper RB dependent transcriptional regulation at mitotic centromeres preserves genome stability www.life-science-alliance.org/content/9/3/... in our Cancer Biology Collection 2026: www.life-science-alliance.org/content/canc...

SATB1 regulates FoxP3 expression, preserving lineage fidelity in conventional CD4+ T cells maintaining FoxP3 target gene repression in Tregs. Deleting SATB1 disrupts Treg function, unleashing potent anti-tumor immunity. www.life-science-alliance.org/content/9/10...

In a male rat model of metabolic syndrome, renal denervation before the high-fat diet has only a transient effect, suggesting that hypercaloric diet-induced endocrine changes trigger hypertension independently of renal sympathetic activity. www.life-science-alliance.org/content/9/10...

Take a look at this Methods paper recently published in LSA: DiffMethylTools:a toolbox of the detection, annotation and visualization of differential methylation www.life-science-alliance.org/content/9/9/...

smn-1 silencing in C. elegans caused distinct defects in neuronal process morphology with pronounced neuron-specific differences in sensitivity between neurons of the same class. www.life-science-alliance.org/content/9/9/...

Septin7 is widely considered essential for cell division. Surprisingly, deleting Septin7 in lymphoid and myeloid cells does not impair blood cell development. We show that Septin7 is required during early hematopoiesis but not at later stages. www.life-science-alliance.org/content/9/10...

This work in our Genetics, Genomics, and Epigenomics collection illustrates the importance of accounting for EPIC version in DNA methylation-based tools, specifically in research scenarios when samples profiled across different versions are harmonized. www.life-science-alliance.org/content/gene...

Check out this paper in LSA: TERT drives liver tumorigenesis beyond telomere elongation @cnrs.fr www.life-science-alliance.org/content/9/9/...

Pant et al. show that deleting exon 2 of Sptlc1 has dosage-dependent effects in mice: homozygous deletion is lethal, while heterozygous mice remain neurologically normal. @deveshp.bsky.social www.life-science-alliance.org/content/9/9/...

New @LSAjournal! CDK4/6i & doxorubicin push cancer cells down very different molecular paths into senescence, but both have NF-κB inflammation (SASP). Blocking NF-κB cuts SASP without reversing arrest! www.life-science-alliance.org/content/9/9/...

This one protein accounts for almost all Ca2+-dependent repair by activating at least 3 distinct pathways. www.life-science-alliance.org/content/9/9/...

Filling a critical gap in the human interactome, we define a comprehensive peroxisomal interaction network that enables network-based hypothesis generation for tissue-specific function, disease mechanisms, and therapeutic exploration. www.life-science-alliance.org/content/9/9/...

In our Cancer Biology Collection, this Perspective explores how the Integrated Stress Response maintains homeostasis during acute stress but may become maladaptive when chronically engaged, driving pathological cell trajectories with key implications in chronic diseases.

“We chose Life Science Alliance because we value its reputation for publishing high-quality research that contributes to the foundational knowledge of our field.” — Jérémie Rossy, University of Konstanz. Learn more about LSA: hubs.ly/Q04ldCnb0

Dual-omics profiling of spontaneous myopia in guinea pigs reveals distinct susceptibility and remodeling states. Human GWAS integration and CYP26A1 validation support relevance to human myopia. www.life-science-alliance.org/content/9/9/...

An accessible, label-free mass spectrometry workflow resolves single cells from patient skin tumors, identifying immune populations and biology that bulk proteomics overlooks. @reviewcommons.org www.life-science-alliance.org/content/9/9/...

An integrated pipeline accurately identifies differentially methylated loci and regions, linking these epigenetic signals to biological functions through robust annotation and visualization www.life-science-alliance.org/content/9/9/...

The study identifies a UCA1-miR-148b-mediated regulatory axis that modulates fetal hemoglobin expression in adult erythroid cells, highlighting a potential RNA-based therapeutic strategy for β-hemoglobinopathies. www.life-science-alliance.org/content/9/9/...

Check out this Resource paper in our Genetics, Genomics, and Epigenomics Collection: TaoChongBao: A Large-Scale C. elegans Missense Variant Database Bridging Worm and Human Genomes 👇 www.life-science-alliance.org/content/gene...

Mice expressing Tert or its inactive variant under the 21 promoter develop HCC with distinct mutational profiles, prompting a reassessment of Tert's role in hepatocellular carcinoma generation. @cnrs.fr www.life-science-alliance.org/content/9/9/...

A new mouse model reveals dosage-dependent effects of Sptlc1-ALS. Deletion of exon 2 causes early lethality in homozygous mice, while heterozygotes show no ALS-like phenotype. @deveshp.bsky.social www.life-science-alliance.org/content/9/9/...

This study presents a comprehensive peroxisomal interactome: 92 proteins profiled, 333 novel interactions identified, & 29 drug repurposing candidates prioritized. A new systems-level resource to uncover disease mechanisms and therapeutic opportunities. www.life-science-alliance.org/content/9/9/...

How do cnidarians respond to stress? 🪸 This study shows that HSP60 regulation differs across three cnidarian species, revealing lineage-specific stress responses and offering new insights into coral resilience and bleaching in a warming ocean. www.life-science-alliance.org/content/9/9/...

This study uses retina-choroid-sclera dual-omics to map molecular programs in spontaneous myopia, identifying a primed susceptibility state, a remodeling state during progression, and translational links to human myopia genetics. www.life-science-alliance.org/content/9/9/...

In our July issue: How the thyroid copes with high oxidation in fish and mice, how germline cells suppress transposable elements, and a microRNA generated in lysosomes. Check out these and more 👇️ www.life-science-alliance.org/content/9/7

#coral #cassiopea and #aiptasia heat shock proteins www.life-science-alliance.org/content/9/9/...

The TRK-T3 oncogenic fusion protein forms biomolecular condensates driven by a hydrophobic segment that drives both morphology and MAPK activation. @ucsandiego.bsky.social www.life-science-alliance.org/content/9/9/...

The study identifies site-specific SINE B2 RNA editing as an early epitranscriptomic response to amyloid beta neurotoxicity in the mouse hippocampus. www.life-science-alliance.org/content/9/9/...

Protein condensates are emerging as organizers of cell signaling. Here, a cancer-associated RTK fusion forms condensates whose organization directly controls growth signaling strength. @ucsandiego.bsky.social www.life-science-alliance.org/content/9/9/...

This study identifies site-specific SINE B2 RNA editing as an early epitranscriptomic response to amyloid beta neurotoxicity in the mouse hippocampus. www.life-science-alliance.org/content/9/9/...