🧠 Is #mentalhealth a mediator between nonsurgical interventions and pain and function in people with #OA 🔓 Read more for free in this month's issue from Richelle Caya et al. - www.oarsijournal.com/article/S106...

#Denosumab use was associated with a reduced risk of knee #osteoarthritis compared with bisphosphonates in adults with osteoporosis, Read more from Zhaohua Zhu et al. in this month's issue - www.oarsijournal.com/article/S106...

🦵 New in this month's issue! The prevalence of #varusthrust is 27% of individuals with knee osteoarthritis Prevalence also increases with greater structural OA severity and is higher in people with varus alignment. Read for free from Haonan Shen et al. - www.oarsijournal.com/article/S106...

#New #Basic #Science in #OAC This month Mohana-Borges et al. assessed the mysterious meniscus ossicle and their role in #knee OA. Read more: www.oarsijournal.com/article/S106... #Basic #Science in #OAC

August's Editors Choice (Clinical) is all about #ACI Snow et al investigated the long-term effects of #autologous chondrocyte implantation (ACI) and found it to be an effective option vs alternative forms of surgical cartilage management in the knee www.oarsijournal.com/article/S106...

New findings this month! CREB5 protects against intervertebral disc degeneration by inhibiting ferroptosis and mitochondrial oxidative stress via the NR4A1–PGC-1α axis. A novel therapeutic target for IDD! #Ferroptosis #IDD #Mitochondria #CREB5 Read more🔗: www.sciencedirect.com/science/arti...

New in #OAC! Heluany et al. identified miR-544a-3p as a new, important modulator of the Wnt signalling network within the articular cartilage! Read more to determine how miR-544a-3p modulates cartilage homeostasis! 🔗: www.sciencedirect.com/science/arti...

🧘 Yoga and osteoarthritis Yoga was associated with lower societal costs and slightly higher QALYs compared to strength training for knee #osteoarthritis Read more from Bedru Jemal Abafita and colleagues in this month's issue - www.oarsijournal.com/article/S106...

🔥 New this month about #metformin 💊 10 year cumulative #osteoarthritis incidence in metformin initiators were 3% lower than non-initiators Read more from Magnusson et al. - www.oarsijournal.com/article/S106...

🤔 Are clinical guidelines for knee osteoarthritis failing the global population? This months Editors Choice (Clinical) looked at 241 RCTs to reveal some blind spots Read for free from Low et al. - www.oarsijournal.com/article/S106...

New in #OAC Cartilage breakdown in #OA is driven by proteinases. Wilkinson et al. stresses that understanding and measuring proteinase activity - or historical evidence of activity - should be an important consideration in basic OA research. Read more 🔗: sciencedirect.com/science/arti...

🚀 OAC is on the rise! The 2025 Journal Impact Factors just dropped and OAC continues to be one of the top journal destinations for our community. Huge congratulations and thanks to our dedicated editors, authors, reviewers, and staff! Let's keep the momentum going. 📈

👀 Must read in this month's issue on new early imaging biomarkers of osteoarthritis Read for free by Gareth Jones et al. - www.oarsijournal.com/article/S106...

🔥 Just out! The first of OAC's Osteoarthritis "Fundamental series" covers #diagnosis and #assessment A clinician’s diagnosis is a vital step to facilitate access to and engagement with treatment. Read more from Lauren King and Abhishek Abhishek here: oarsijournal.com/article/S106...

📈Knee arthroplasty in OECD countries has hit a tipping point New study by Backes, Pabinger, Lothaller & Geissler tracked 25 countries over 17 years and found that patients under 65 now make up >50% of all procedures - up from ~37% in 2005. Read for free: www.oarsijournal.com/article/S106...

#New this month our #Basic #Science Editor's Choice for #June. PAR2 in bone accelerates late-stage OA, showing bone turnover’s key role in joint damage and the age- and cell-specific complexity of PAR2. #Osteoarthritis #BoneHealth Read more 🔗: www.sciencedirect.com/science/arti...

🦴Is waiting for knee replacements (TKR) slowing down drug discovery? Using intermediate endpoints might make trials faster: 🔹CKOASO: Cuts sample size from 3,000 to 229 🔹esKOA: Strongest predictor of future TKR (5.7RR) 🔹FNIH: High feasibility doi.org/q5p8

Getting geared up for OARSI?🤩 Mark your calendars for the OAC/OAC Open Journal Session on April 23rd, 2026 11 am-12:30 pm EST. 🌴

Our #Basic #Science infographic for the month of #April is this work by Sun et al. This work investigates the role of ac4C modifications in cartilage endplate degradation as a result of excessive compression. Read more: sciencedirect.com/science/arti...

Have you ever wondered how synovial fibroblasts respond to different types of injury? Collins et al. used single-cell RNA-sequencing to study the fibroblast responses to different types and duration of joint injury in mice. Read more📑: www.oarsijournal.com/article/S106...

Why does a bad night’s sleep make everything hurt more? On this week's JointAction podcast, @profdavidhunter.bsky.social hosts Prof. Michelle Hall to explore the cycle between sleep and pain, and offer some practical strategies to help regain both rest and relief. shows.acast.com/joint-action...

Our #OMICs #Special #Issue features work by Jachim et al. identifying gene regulatory networks that drive human articular cartilage cell fate and establishing an in vitro model showing promise as a tool to study cartilage development and homeostasis. 🔗: oarsijournal.com/article/S106...

🤔 Is there a relationship between osteoarthritis (OA)-induced neuroinflammation and neurodegenerative disorders? 👀 Read all about this interesting topic in this review by Prasoon et al - oarsijournal.com/article/S1063-…

The basic science #EditorsChoice for #Feb is this work by de Roy et al. Learn about the tribological impact of synovial fluid (SF) viscosity and composition during the different stages of #OA! Read more📚: www.oarsijournal.com/article/S106...

🏳️‍🌈 Sexual orientation and #OA ⏰ Feb's Editor's Choice by Sha et al. investigated the relationship between #sexualorientation and OA risk in LGBTQIA2S+ population ✅ They found a higher risk of OA in bisexual & lesbian women but a lower risk in gay men oarsijournal.com/article/S106...

This month in #OAC Hyodo et al. assessed the effects of imeglimin, a novel anti-diabetic agent related to metformin, on the development and progression of knee #OA. Read more 📚: sciencedirect.com/science/arti...

More #Basic #Science in #OAC this work by Simoes et al. develops a #translational strategy inhibiting aggrecanase activity in #OA using TIMP-3. Learn more 🔗 sciencedirect.com/science/arti...

New in #OAC, Xu et al. investigates parathyroid hormone-related peptide nuclear localization segment (PTHrP-NLS) and parathyroid hormone 1 receptor (PTH1R) signal-dependent rehabilitative effects of CD90+ chondrocytes on degenerative TMJ cartilage. oarsijournal.com/article/S106...

How do sex differences in the brainstem alter experimental #osteoarthritis ?🧐 Check out this work by Rodrigues et al. www.sciencedirect.com/science/arti...

Ziemian et al. demonstrates repetitive loading induced protective effects in the joint & attenuated OA progression over time relative to a single bout of loading even when applied at hyperphysiological load magnitudes known to initiate cartilage damage. Read more🔗 pubmed.ncbi.nlm.nih.gov/40020990/