Plenty of dust/sand zooming across the Atlantic all the way to the Caribbean and Gulf of the Mad King. (PM₁₀ & surface winds)

Typhoon Bavi is right on course to make landfall just north of Wenzhou, a city of ~ 10 million people.

#proteomics_101 How would you go about estimating the number of tyrosine kinases necessary to generate this pattern of pY acceptor occupancy in human or mouse KIT:p?

Typhoon Bavi is heading for the north coast of Taiwan & on course for landfall at Wenzhou, China.

proteomics_101 Yeast ELO3 is an ER type II membrane enzyme that extends very long fatty acids. It has 6 or 7 TM regions, depending on which algorithm you ask. How would you go about determining which is correct & explain why "both" isn't a viable answer?

The trillion dollar goofball managed to come up with a grammatically correct but even more giggle-inducing alternative than any that had occurred to me.

Heat Shock (transcription) Factors 1 & 2 are frequently discussed in the literature as very similar paralogs. However, HSF1:p seems to use exon 9 as a cyclin-dependent regulatory element via S+phosphoryl acceptors, while HSF2:p does not. Provide the case for […] [Original post on mastodon.social]

#proteomics_101 Develop a classification scheme for these 8 E2F transcription factors based on their phosphorylation & 3D structure patterns. How does this classification scheme compare with the conventional grouping of these proteins into activators & repressors.

The thing that will usually cause me to bail out of accessing a web site before I even get there.

#proteomics_101 Why does UniProt's list of Gene Ontology terms for yeast ACL4:p include entries associated with mitochondrial outer membrane transport, even though the only known function of this protein is to act as an important chaperone for mitochondrial assembly?

Looks like there may be some #aurora tonight in North America!

The Ω pattern that is causing the heatwave in Europe this week. (winds @ 250 hPa)

In the final instalment of the #queso_conundrum, SkyNet tips its hand on the choice of materials for a new Terminator weapons system.

#queso_conundrum These parables are an amusing example of a category error where LLMs fail badly if used to discover new things. They have no info regarding cheese as a structural material, so when asked they generate the appearance of an argument based they […] [Original post on mastodon.social]

#queso_conundrum of the day. I particularly like the storage suggestions at the bottom of the page to show that it is serious about the durability of its suggested Russian cheese.

The markets' ability to accurately price the value of a company has moved solidly from "the wisdom of the crowd" to "the madness of crowds" in just 1 year.

POR1:p uses β-strand transmembrane domains that are only 10 residues long held in place by extensive inter-strand hydrogen bonds. This makes it possible to pack 19 into the 283 residue sequence. This type of TM does not cause any problems for MS-based proteomics: >90% coverage is not unusual.

#queso_conundrum Even though the trillion dollar mechanical Turk believes it has found a solution, there are no words to describe the horror show that would result from using ground cheese (of any type) as cat litter.

#queso_conundrum I frequently hear that one of the motivations behind spending more money than exists on LLM-based systems is their potential to revolutionize science & medicine. Seems a bit too much "Pinky" and not enough "the Brain" for my tastes.

The jet stream (winds @ 250 hPa) in the Northern Hemisphere is a pretty tangled skein at the moment.

Another #queso_conundrum, this time enthusiastically taking on the task of replacing lab benches with slabs of Pecorino Sardo, potentially creating a run on its renewable source material (Sardinian sheep's milk). Can world domination be far off?

Plenty of precipitable moisture (cyan) piled up by the wind on the northern coast of the Gulf of the Mad King will result in lots of rain for the next day or two.

@dtabb73 The PTM in question is the formation of a 2nd carboxylate group on glutamic acid to form γ-carboxyglutamic acid in a small number of key proteins, significantly altering their function by promoting intramolecular calcium binding.

Another #queso_conundrum (this time sin queso) provides a garden path to go down if you want to waste a year or two proving that a simple back-of-an-envelope was correct: if you want to do MALDI you are stuck with a pulsed laser.

Another #queso_conundrum. I'm guessing that there are lots of references to cheese shapes in its text corpus, so the syntactical hop-scotch leading from "brick of cheese" to "brick made of cheese" to "load bearing wall made of cheese" was a predictable outcome.

This is the sort of LLM-led material science breakthrough that I am expecting to see in the next generation of Teslas (particularly the Cybertruck 2).

I can hardly wait until the first generation of products designed by these little rascals. And, for the impressionable amongst us and for the love of God, do not use anything described as "floss" as a clothesline.

After yesterday's revelation of a break-through in mass spectrometry design (replacing all that 316 stainless steel with the much easier-to-machine Parmesan cheese), Gemini's LLM has another blockbuster realization, this time taking on the HPLC cartels.

#proteomics_101 Referencing the attached diagram, propose a membrane topology for the yeast ER protein ALE1:p (lysophospholipid acyltransferase); TMs are marked in grey. Also, propose at least 1 testable hypothesis for why & when pS acceptors might be used to modulate the activity of this enzyme.