Signal Transduction and Targeted Therapy
@sigtrans-sttt
Signal Transduction and Targeted Therapy (STTT) | A Nature Portfolio journal | Impact Factor 52.7 | Q1 in Biochemistry, Cell Biology & Molecular Medicine | Open Access Visit:
Learn how aging influences cancer development and treatment efficacy. This review explores shared #molecularpathways and emerging therapeutic strategies that advance healthy aging and #cancerprevention and treatment. #OpenAccess in #STTT: doi.org/10.1038/s413...
Tumor-derived EVs often suppress immune responses, limiting #Cancer treatment. Researchers developed #Nanoproteolysis-targeting chimera (EVOTAC) that reprogram these vesicles toward immunogenic phenotypes to boost anti-tumor responses. #STTT #OpenAccess: doi.org/10.1038/s413...
New therapeutic strategies are needed to overcome treatment resistance in #MultipleMyeloma. Inhibiting COPII-dependent endoplasmic reticulum export disrupts proteostasis and metabolic resilience, suppressing tumor growth. #STTT #OpenAccess: doi.org/10.1038/s413...
#StressHormones prioritize cardiac energetics! This study identifies a two-strata energy flux system that prioritizes cardiac energetics during physiological demand coordinating metabolic regulation and #CardiovascularHomeostasis. #STTT #OpenAccess: doi.org/10.1038/s413...
More effective #Antivirals are needed against emerging viral threats. In this study, researchers developed novel brincidofovir and HPMPA derivatives with greater potency against #Orthopoxviruses and human #Adenoviruses. @fudan-university.bsky.social #OpenAccess in #STTT: doi.org/10.1038/s413...
What controls #LipidHomeostasis in alcohol-associated liver disease? This study identifies the AKAP12-PKA axis as a key regulator of hepatic lipid metabolism and a promising #TherapeuticTarget against #LiverInjury. #STTT #OpenAccess: doi.org/10.1038/s413...
#Atherosclerosis and #VascularCalcification remain difficult to treat. This study shows that the tripeptide DT-109 reduces these pathologies in primates by targeting #OxidativeStress, supporting its translational potential. #STTT #OpenAccess: doi.org/10.1038/s413...
Chronic stress is a major driver of #AtrialFibrillation. This study links #ChronicMildStress to atrial fibrillation through S100A8/A9-driven neutrophil extracellular trap formation, revealing a #TherapeuticTarget. #STTT #OpenAccess: doi.org/10.1038/s413...
How does #WntSignaling influence health & disease? This review in #STTT explores canonical & non-canonical pathways, regulation and therapeutic advances targeting Wnt signaling across multiple disorders. #OpenAccess: doi.org/10.1038/s413... #Cancer #RegenerativeMedicine #LifeSciences
#Phototherapy is reshaping #Cancer treatment through advances in photodynamic, photothermal & #Photoimmunotherapy. This review details the mechanisms, delivery strategies, clinical progress & challenges limiting its translation. #BiomedicalResearch #STTT #OpenAccess: doi.org/10.1038/s413...
Excessive #Inflammation during #InfluenzaA infection causes severe tissue damage. This study identifies Ninjurin-1 as a driver of #PANoptotic cell lysis and inflammatory responses, revealing a potential #TherapeuticTarget. @tsinghuauniversity.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...
Achieving broad-spectrum protection against diverse #Influenza strains? A new #Nanobody-based #PROTAC shows promise by targeting and degrading viral proteins, thus providing broad-spectrum protection against diverse influenza viruses. #OpenAccess: doi.org/10.1038/s413...
How do tumors promote immune suppression? This study identifies proton-sensing GPR65 as a regulator of the immunosuppressive #TumorMicroenvironment, highlighting a promising target for #Cancer #Immunotherapy. @unimainz.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...
This study shows that #Hypoxia-induced microRNA-27b drives pathological cardiac endoreplication, providing mechanistic insights and highlighting it as a potential #TherapeuticTarget for #CardiacDiseases. @goetheuni.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...
How do #Glycosylation sites affect vaccine immune response? This review explores the mechanisms influencing #COVID19 vaccine #Immunogenicity, providing guidelines for designing effective & resilient vaccines for better protection. #STTT #OpenAccess: doi.org/10.1038/s413...
Immune suppression limits #Myeloma treatment. SSTNIV, a syndecan-1-targeting #PeptideChimera, reverses immune suppression by remodelling the immune microenvironment, offering a promising strategy to inhibit disease progression. @unmc.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...
Understanding disease cellular crosstalk is complex. This study presents #iS2C2, a cointelligent platform that integrates #ArtificialIntelligence with biological expertise to uncover mechanisms of disease-associated cellular crosstalk. #STTT #OpenAccess: doi.org/10.1038/s413...
This randomized, controlled phase 2a trial evaluated the acute effects of #TPN171H and demonstrated favorable hemodynamic improvements with an acceptable safety profile, supporting further clinical development. #STTT #OpenAccess: doi.org/10.1038/s413... #Therapeutics #HeartHealth
Durable responses in advanced #NSCLC remain challenging. This study shows that low-dose #Radiotherapy enhances PD-1 blockade by reprogramming neutrophils, improving antitumor immunity and survival in #LungCancer. #STTT #OpenAccess: doi.org/10.1038/s413...
This study identifies ADAMTS4 as a driver of #LiverFibrosis in metabolic dysfunction-associated steatotic liver disease (#MASLD), showing that targeting ADAMTS4 reduces myeloid cell recruitment, liver injury, and #Fibrogenesis. #OpenAccess in #STTT: doi.org/10.1038/s413...
This phase II SILENSES trial showed that sintilimab plus lenvatinib converted advanced unresectable #HepatocellularCarcinoma to resectable disease in over half of patients, enabling curative surgery and durable survival benefits. #STTT #OpenAccess: doi.org/10.1038/s413...
How does protein #Lactylation regulate cellular function in health and disease? This review explores the mechanisms, biological roles, and implications of protein lactylation in metabolic regulation and disease #Pathogenesis. #STTT #OpenAccess: doi.org/10.1038/s413...
This randomized phase III trial showed that first-line orelabrutinib improved progression-free survival and demonstrated a favorable safety profile compared with #Chemoimmunotherapy in treatment-naive #CLL/SLL. #STTT #OpenAccess: doi.org/10.1038/s413... #Oncology #CancerResearch
The phase II NAIVE study shows that tislelizumab + #Neoadjuvant #Chemotherapy improves tumor responses and surgical outcomes in advanced epithelial #OvarianCancer while identifying immune signatures linked to treatment benefit. #STTT #OpenAccess: doi.org/10.1038/s413...
Demonstrating GRANPA, an engineered inhibitory #Chemogenetic receptor activated by the brain-permeant antihistamine diphenhydramine, enabling reversible neuronal silencing and on-demand seizure suppression. @ucl.ac.uk #STTT #OpenAccess: doi.org/10.1038/s413...
Why does #ColorectalCancer spread to the liver? This study in #STTT reveals how ENO2 drives M2 macrophage polarization, creating a pro-#Metastatic #TumorMicroenvironment. Discover the mechanism here: www.nature.com/articles/s41...
Could your existing measles immunity boost cancer therapy? Researchers from @upv.es used mRNA-lipid #nanoparticles to express measles hemagglutinin, significantly enhancing antitumor T cell responses. #STTT #OpenAccess: doi.org/10.1038/s413... #TumorImmunology #Oncology
Can processing alter the therapeutic activity of plant-derived RNAs? This study shows that processing methods influence the integrity, uptake and #Bioactivity of the honeysuckle-derived #miRNA MIR2911. #STTT #OpenAccess: doi.org/10.1038/s413...
This study identifies HDAC-dependent #Epigenetic repression as the cause of osimertinib-induced #Cardiotoxicity and shows that vorinostat restores cardiac function while maintaining anticancer efficacy. #STTT #OpenAccess: doi.org/10.1038/s413...
Can #Thrombosis be prevented without compromising hemostasis? This study in #STTT demonstrates that partial downregulation of platelet glycoprotein VI by low-affinity antibodies provides sustained, safer #Antithrombotic protection. @uni-wuerzburg.de #OpenAccess: doi.org/10.1038/s413...