✨ New metal-free route to fluorescent spirooxindoles! K-10 clay enables the #synthesis of green-emissive fluorophores in excellent yields in just 45 min. The method also features a domino hydrogen-harvesting step for more #sustainable fluorophore synthesis. 🔗 Read now: bit.ly/4pW4KaB #ChemSky

👋 Meet the Editorial Board! Dr. Ch. Raji Reddy (CSIR–IICT, India) is a member of the #SynOpen Executive Board. His research spans propargylic alcohols, enyne-assisted annulation, dearomatization, complex API development, and N-cyanamide chemistry. 🔗 bit.ly/44SydIB #MeetTheEditors

A simple route to new functionalized benzazoles! This one-pot, copper-catalyzed C–H activation strategy delivers new sulfonyl-imine benzazoles from readily available starting materials under mild conditions, with yields of up to 92%. 🔗 Read now: bit.ly/3RrGQXJ #ChemSky #OrganicChemistry #OpenAccess

👋 Meet the Editorial Board! Prof. Tian-Sheng Mei (Shanghai Institute of Organic Chemistry, China) is a member of the #SynOpen Executive Board. His research focuses on transition-metal-catalyzed electrosynthesis reaction. 🔗 bit.ly/44SydIB #MeetTheEditors

🧪 New possibilities for the Horner–Wadsworth–Emmons reaction! Using KHMDS, the authors developed a practical route to 3-iminoacrylic esters, valuable ketenimine building blocks rarely accessed by HWE chemistry. 🔗 Read more: bit.ly/4poUVBQ #ChemSky #OrganicChemistry

👋 Meet the Editorial Board! We're launching a new series introducing the team behind #SynOpen. First up: Editor-in-Chief Prof. Thierry Ollevier (Université Laval, Canada). His research focuses on catalyst design, diazo & diazirine chemistry, and green synthesis. 🔗 bit.ly/44SydIB #MeetTheEditors

🧪 New pyrazolo[1,5-a][1,3,5]triazines with promising anticancer activity! Lead compounds showed broad-spectrum growth inhibition, low cytotoxicity, and favorable predicted ADMET properties. 📖 Read the full paper: bit.ly/4eT1Zl1 #ChemSky #MedicinalChemistry #CancerResearch #DrugDiscovery

🏆 Congratulations to the winners of the #SynOpen Best Paper Award! 🎉 Limei Qian, Yi Jin & co-workers developed a mild, metal-free PIFA-mediated strategy to access valuable 2-hydroxy diarylureas. A scalable, efficient & more sustainable approach! Read the paper: bit.ly/3Su93gG #ChemSky #OpenAccess

🏆 Join the next Thieme Cheminar! Hear from the award-winning authors recognized by SYNTHESIS, SYNLETT, and SCNow. Chaired by Prof. Tanja Gulder, Assoc. Editor of @synlettjournal.bsky.social 📅 June 24, 2026 ⏰ 14:00 CEST 👉 Register here: bit.ly/3QtzzpM #Cheminar #ChemSky #OrganicChemistry

🧬 New paper on SIRT1 activators! This study reports new 1,5-benzodiazepine-based SIRT1 activators, combining organic synthesis, #molecular docking & biological evaluation. A lead compound demonstrated promising #antidiabetic activity in vivo. 🔗 Read now: bit.ly/4xkL1EK #ChemSky #MedicinalChemistry

🧪 Carbene or nitrene? This graphical review explores the diverse landscape of #carbene and #nitrene precursors, highlighting their synthesis, activation strategies, reactivity profiles & key synthetic applications. 🔗 Read here: bit.ly/4x2HBpT #ChemSky #OrganicChemistry #Synthesis

⚗️ From our #Catalysis Virtual Collection An aryl iodide-catalyzed oxidative strategy enables intramolecular C–N/C–O bond formation from diphenylpropanamides under mild, transition-metal-free conditions. 🔗 Read the full paper: bit.ly/3RX5qPP #ChemSky #OrganicChemistry

💡 From our #Catalysis Virtual Collection A metal-free iodide/peroxide strategy for direct C–H functionalization of quinoxalin-2(1H)-ones via cross-dehydrogenative coupling & arylation. Efficient access to valuable heterocycles! 🔗 Read here: bit.ly/4nvE66Z #ChemSky #OrganicChemistry

⚡ From our #Catalysis Virtual Collection An aerobic iron(III)-catalyzed direct thiolation of imidazo[1,2-a]pyridines enables regioselective access to C3-sulfenylated heterocycles under mild conditions. Efficient #synthesis with promising bioactive derivatives! 🔗 Read now: bit.ly/4eVcCpt #ChemSky

💡 From our #Catalysis Virtual Collection A visible-light-mediated photocatalytic oxidative cleavage of geminal diazides, using an organic dye as catalyst, enables efficient access to oxamates under mild, metal-free conditions. 🔗 Read here bit.ly/4utWTlC #ChemSky #OrganicChemistry #Photocatalysis

🚀 From our #Catalysis Virtual Collection An atom-economical, iodine-catalyzed oxidative route to olivetol, methyl olivetolate & protected derivatives from common precursors. A mild, efficient & scalable approach to valuable building blocks. 🔗 Read more: bit.ly/41ZwGzc #ChemSky #OrganicChemistry

🧪 1,1-Dibromoolefins: versatile building blocks in synthesis! Featuring two reactive C–Br bonds, they enable rapid access to heterocycles, functionalized olefins & alkynes from simple precursors. 📚 Explore the graphical review: bit.ly/4dU0yEk #ChemSky #OrganicChemistry #Synthesis

Discover boron chemistry in #catalysis in our next Thieme #Cheminar with our speakers Hirohisa Ohmiya (Japan), Elena Fernández (Spain), and James Morken (USA). Chaired by Martin Oestreich. 📅 Apr 14 | 🕑 14:00 CET 👉 Sign up now to save your spot: bit.ly/4t2czfA #ChemSky

🧪 Efficient Pd/C-catalyzed hydrogenation of diene carboxylates! A catalyst from Pd₂(dba)₃ on activated carbon (5% Pd) delivers high yields of fully saturated products, including challenging 5-membered rings. 🔗 Read more: bit.ly/4mbFnQk #ChemSky #Catalysis #OrganicChemistry

Join the Thieme Chemistry Journals Awardees 2026 #Cheminar and explore cutting-edge research in #photocatalysis, #sustainable solvents, novel #heterocycles & more. 📅 Mar 30 🕔 4 PM CEST 👉 Register here: bit.ly/4uOWN95 #ChemSky #OrganicChemistry

⚡Electrophotocatalysis for C(sp²)–H functionalization! Graphical review by Jiusi Yang & Peng Qian on #photoelectrocatalytic C–H activation, merging light & electricity for selective functionalization of arenes, heteroarenes, #alkenes & imines 🔗 Read now: bit.ly/4799ul2 #ChemSky #Photochemistry

🧪 Copper #catalysts for alcohol #oxidation This graphical review highlights advances in Cu-catalyzed oxidation and dehydrogenation of alcohols (2015–present), including aerobic oxidation, acceptorless dehydrogenation, and homogeneous & heterogeneous systems! 🔗 Read now: bit.ly/3Pif6TL #ChemSky

⚡ Greener alcohol oxidations! Graphical review by @conchem.bsky.social & Prof. @klchemistry.bsky.social on non-transition-metal electrochemical #oxidation of alcohols. Featuring TEMPO and other mediator systems in #electrosynthesis. 🔗 Read more: bit.ly/4rRzoSr #OrganicChemistry #ChemSky

💡 Visible light unlocking #heterocycles! Eosin Y–catalyzed reductive cyclization of N/O-aryl bisenones affords functionalized pyrrolidines & THFs, exclusive trans #isomers & enantioenriched products! 🔗 Read the full paper: bit.ly/4tXrvwj #ChemSky #Photochemistry #OrganicChemistry

🚨 Last call to the Thieme #Cheminar! “Strain-Release Chemistry” with speakers Dr. Durga Hari (🇮🇳), Prof. Jérôme Waser (🇨🇭) @lcsolab.bsky.social & Prof. Peter Wipf (🇺🇸). Chaired by Akkattu T. Biju (Assoc. Editor of @synthesis1969.bsky.social) 📅 Feb 24, 2026 | ⏰ 11:00 AM(CET) 🔗 Register: bit.ly/4kGHtqm

📢 Join our next Thieme #Cheminar! 🧪 Strain-Release Chemistry 📅 Feb 24, 2026 | ⏰ 11:00 AM (CET) Discover how strained #molecules open new pathways for innovative transformations. Chaired by Akkattu T. Biju (Associate Editor of @synthesis1969.bsky.social) 🔗 Register here: bit.ly/4kGHtqm

🧪 New quinazoline-based #lidocaine analogue Scalable 7-step synthesis (10-g scale) delivers a promising next-generation local anesthetic with enhanced activity and improved pharmacokinetic profile! 🔗 Read the full paper: bit.ly/4rXt4Zw #ChemSky #MedicinalChemistry #DrugDiscovery

An efficient and mild dibromination of aromatics using Fe(NO₃)₃·9H₂O/FeBr₃ at room temperature. This protocol delivers good to excellent yields, avoids hazardous Br₂, and is scalable to gram scale. 🧪 🔗 Read here: bit.ly/4riD0gk #ChemSky #OrganicSynthesis #Halogenation #GreenChemistry

🌱 Polar organometallic reagents can thrive in #sustainable solvents! This graphical review highlights how organolithium, #Grignard, and related #reagents operate in water and deep eutectic solvents, redefining classical reactivity through #GreenChemistry. 🔗 Read now: bit.ly/4qVloXj #ChemSky

🧩 Sterically controlled, template-assisted macrocyclization enables hemisquaraine #rotaxanes with enhanced #fluorescence and stability. By combining #SupramolecularChemistry, photophysics, and DFT, this study reveals how steric effects control rotaxane formation. 🔗 Read here: bit.ly/3ZE8UaF