🗺️ Mapping RNA modifications: #Yeast study uses Nanopore sequencing and adapted D-seq method to map base modifications across mitochondrial tRNAs. Identifies Dus1 and Smm1 enzymes responsible for specific dihydrouridine sites 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🎮 Mitochondrial fine-tuning: #Yeast phospholipase Fmp30p controls PI lipid levels ➡️ regulates CoQ production. When PI accumulates, CoQ biosynthesis increases with enzyme expression, showing how membrane lipids control energy metabolism 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💌 Molecular matchmaking for DNA repair: #Yeast Rad55-Rad57-SHU complex selectively delivers Rad51 to damaged DNA sites. Cryo-EM snapshots show how this conserved tumor suppressor pathway works across species 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🧰 Genome editing upgrade! Multiplex CRISPR platform: ✅ enables simultaneous editing of multiple #Yeast genes 🚫 no complex vectors ‼️One editing round modified 9 targets and boosted target production >9fold ➡️ #biomanufacturing applications 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💪 Vesicle protection revealed: #Yeast Atg23 protein is protective escort for Atg9 vesicles during autophagy, preventing premature fusion on way to autophagosome formation sites- phosphorylation switch releases escort on arrival 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🗑️ Protein quality control enhancer: #Yeast Ufd2 (E4 enzyme) adds extra ubiquitin tags to ensure problematic proteins get degraded. Extension system is essential for handling protein stress, maintaining cell health 🧬 #YeastResearch 🧪 #SGD 🔬 @micropub7n.bsky.social www.yeastgenome.org/reference/S1...

🤝 Molecular helper discovered: #Yeast Pbr1 protein's long-mysterious function revealed as Fks1 folding assistant in the ER. Without this helper, cell wall synthesis fails and cells become unstable- teamwork at the molecular level 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🎯 Genome repair targeting: #Yeast Smc5/6 complex preferentially binds single-strand DNA gaps and junctions using its head-NSE module. High-resolution imaging shows "bead-on-stick" structure that homes in on DNA damage sites for repair 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

👉Species-specific enzyme evolution: Human MINDY3's EF-hand domain serves dual purpose, binding long ubiquitin chains AND recruiting DNA repair factors. Comparison to #Yeast homolog Miy2 reveals different cleavage patterns across species 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🧠 Repurposed hypertension drug has potential against #Alzheimer's: Terazosin increases cellular energy production. #Yeast SNF1 mutants provide key testing ground- low ATP cells reveal how enhancing glycolysis reduces protein aggregation 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🏷️ Sugar tag recognition system: #Yeast adds O-mannose tags to misfolded ER proteins as "destroy me" signals. Study suggests Emp46 & Emp47 lectins read these tags and escort tagged proteins to ERAD degradation machinery for elimination 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📡 Powerhouse ↔️ Command center: Mitochondria coordinate stress responses by integrating signals between organelles via physical contacts & retrograde pathways, revealing roles beyond energy production! Mechanism conserved #Yeast ➡️ human 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🌱 Plant waste to biofuel breakthrough: #Yeast naturally can't efficiently transport C5 sugars from plant biomass. Advanced protein engineering creates specialized transporters for sustainable bio-based industrial production 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🥳🎉 Yippee for stress resistance: #Yeast Yippee-like protein Moh1 creates cellular trade-offs. Increased resistance to H2O2 & acetic acid but greater sensitivity to sodium azide & sulfuric acid, linking metabolism to selective protection 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔍 Hidden interaction hub: #Yeast SIR complex transitions from dynamic spreading ➡️ stable chromatin compaction. Sir2 deacetylase connects to Sir4 scaffold through coiled-coil domain, controlling gene silencing switch 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

Join the Pacific Northwest Yeast Club for the 2026 PNWYC annual meeting! July 31st, 2026 at Western Washington University, Bellingham, WA. Registration's FREE. Anyone working in any type of fungal system is welcome! www.pnwyc.net/home

🤼 Chromatin wrestling match: #Yeast Swi-Snf (gene activator) & Tup1-Cyc8 (repressor) battle for control at gene promoters. Both complexes are present simultaneously, with their wrestling match determining whether genes turn on or off 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🚉 Cellular train station: #Yeast nucleus-vacuole junction acts as bustling hub connecting ER and vacuole for lipid metabolism, storage, & transfer; interface adapts its structure & protein residents based on metabolic needs 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🍷Hidden yeast compounds revealed: Profiling 48 wine #Yeast strains revealed previously uncharacterized bioactive lipids (LNAPEs) & major strain differences in beneficial omega-3 & -6 fatty acids; could optimize fermentation & wine quality 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

☄️ Tiny protein, big discovery: Tyc1 (Tiny #Yeast Comet 1) forms braided, comet-tail shaped polymers that wrap around microtubules and prevent their destruction by ice-cold CaCl₂ stress. Cross-species insights into cytoskeleton protection 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🏰 rDNA guardian revealed: #Yeast Paf1 elongation factor prevents transcriptional arrest & maintains rDNA stability. Without Paf1, R-loops accumulate, DNA breaks, and copy number chaos ensues ➡️ transcription quality 🤝 genome integrity 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

💪 Cellular pressure valve: #Yeast uses Csf1 lipid transfer protein to remodel membranes when physical stress threatens bilayer integrity. High pressure reveals hidden lipid remodeling network that maintains flexibility at ER-PM sites 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

📍 Protective positioning system: #Yeast uses nuclear pore protein Nup60 to sequester SUMO protease Ulp1, preventing premature synaptonemal complex breakdown. Engineered tethering rescues defective mutants= location-based enzyme control 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔄 Smart feedback system: #Yeast SNF1 phosphorylates its own activator Sak1 to control nuclear entry timing. Blocking this self-regulation enhances nuclear SNF1 activity and glucose starvation adaptation, self-tuning metabolic control 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔄 Cell cycle safety net: #Yeast G1-cyclin monitors polarity establishment & boosts its own activity when cells struggle to form proper bud axis. Feedback ensures coordination but can create multinucleate cells if defects persist 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🎯 Protein targeting precision: #Yeast SRP (protein escort system) preferentially binds transmembrane domains as they emerge from ribosomes, but only selects minority of signal peptides. New algorithm predicts which proteins reach ER 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

🔎 Strategic elimination approach: With AlphaFold modeling & mutation screening, #Yeast researchers rule out multiple Atg11 regions for Atg9 binding. Valuable #NegativeResults in @micropub7n.bsky.social help guide future search efforts 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...

Thanks to everyone who stopped by our #SGD booth at last night's #Yeast26 poster session! Especially our best bud who's clearly ready for some serious budding yeast research 🐕✨ Who needs AirBud when you've got a YeastBud? 🧬💙 🧪 #SGD #YeastResearch

🔥 Thanks to everyone who came to our #Yeast26 #SGD workshop! Great to see so many ready to level up their #Yeast game! 🙌 Come find us at our poster session table tonight - we're excited to help with #SGD, @alliancegenome.bsky.social & GO tools, answer questions & 🍻🍷 chat about #YeastResearch! ✨🧬

Really great opening so far to ☀️ #Yeast26 🌊, including a superb Winge-Lindegren Address from our very own Gavin Sherlock! 🧬 #YeastResearch #Yeast