John Harrold

@abumirchi

I like math, I make drugs.

1.048 Folgt881 Follower3.849 Posts

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John Harrold@abumirchi· Jul 8

Ninja shoes. I like ninja shoes. www.yamatobudogu.com/cdn/shop/pro...

John Harrold@abumirchi· Jul 4

Looking through this reminds me of one of my favoriate illustrations I made for one on my papers.

Fig. 1. Common subclasses of therapeutic proteins for treatment of autoimmune and other inflammatory conditions based on points of intervention and mode of action. 1 cytokine/cytokine receptor antagonists; 2 lymphocyte-depleting agents; 3 agents that interfere with T cell– receptor (TCR) complex-mediated signal transduction and costimulatory signaling in T cell activation, including tolerance-inducing agents; 4 agents that interfere with cell trafficking or adhesion of T cells to APCs (such as dendritic cells, macrophages, B cells) and/or endothelium (including integrin antagonists); 5 agents that target components of the innate immune system, including anti-complement (5a), anti-chemokine drugs (5b), or drugs targeting cellular components of the innate immune system (5c). Agents in subclasses 1, 3, 4, and 5c may exert their function by blocking the ligand–receptor interactions and/or by downmodulation of the expression of cell surface molecules. Some agents have multiple modes of actions and thus may be included in more than one subclass. Additional therapeutic proteins that do not directly fall in the above subclasses, as described in the text. TCR-associated complex includes TCR, CD3, CD8, or CD4 on T cells and MHC presenting an antigenic peptide on APCs. Costimulatory factors include CD28 and lymphocyte function-associated antigen-1 (LFA) on T cells, CD80, CD86, and intercellular adhesion molecule 1 (ICAM1) on APCs. Phagocytes=dendritic cells, macrophages, and/or neutrophils

John Harrold@abumirchi· Jun 23

I'm doing the post your most recent cooking picture if you’re a straight man. This was breakfast for my kid a couple days ago.

Breakfast oriented like a face. Eyes: two poached eggs, Nose: bread slideced in quarters, and a banana for the mouth.

John Harrold@abumirchi· May 29

I went to start filling out my ballot today and I found this mailer in the pile of stuff. And my first thought was: Wow law enforcement supports Becerra. Then I looked into it and this is a voter guide where you pay to be in it, it has nothing to do with cops, and it's expensive to get in it.

COPS VOTER GUIDE mailer supporting Becerra.

John Harrold@abumirchi· May 17

John Harrold@abumirchi· May 12

So I went to claude design and told it create a web UI for this mine craft server admin service I created. It ground a way and made something that looked pretty cool. So I told it to package it up. I downloaded the zip file and a told claude code to apply that to the current ui.

John Harrold@abumirchi· May 9

My kid wanted to play Java Minecraft and was asking for a PC. I asked Claude about using our Steamdeck because I didn't want to buy a new computer for this. I could have done this with @kagi.com but this got me where I wanted to be pretty quickly. This is a pretty common experience for me w/Claude.

Claud output for: Can you play it on a steam deck?

Yes, you can play Minecraft Java Edition on a Steam Deck! It takes a bit of setup since it's not natively on Steam, but it works well. Here's how:
Method 1: Using the Desktop Mode (Most Common)

Switch to Desktop Mode (hold Power button → Switch to Desktop)
Open the Discover Software Center
Search for and install PrismLauncher (a free, open-source Minecraft launcher — works great on Steam Deck)
Log in with your Microsoft account and install Java Edition
Launch and play!

Method 2: Add to Steam (for Game Mode)
After installing via PrismLauncher, you can add it to Steam so you can launch it from Gaming Mode:

In Desktop Mode, open Steam → Add a Non-Steam Game
Browse and select the PrismLauncher executable
Now it'll appear in your Steam library and can be launched from Game Mode

Controls

Java Edition is designed for keyboard & mouse, so you'll want to either:

Use a Bluetooth keyboard/mouse
Or configure the Steam Deck's trackpads and gyro as mouse input (works surprisingly well)
Install a mod like Controllable for full controller support

Performance

Minecraft Java runs well on the Steam Deck
You can get solid 60+ FPS with default/medium settings
Adding OptiFine or Sodium (performance mods) can boost it further

John Harrold@abumirchi· May 9

It costs like $9 a month but @kagi.com is like google used to be and they don't sell your data.

Screenshot of kagi search for "police in spanish" with automated translation below it.

John Harrold@abumirchi· May 7

Most of them are just out there. Here is a PDF where you can read their statements: vig.cdn.sos.ca.gov/2026/primary... There are some good ones like this guy:

LivingForGod AndCountry DeMott | NO PARTY PREFERENCE
My Legal Name LivingForGod Means: Living A Life Refecting The Good Character of
Jesus Christ; it is my foundation, my operating system, and compass. As a chaplain it is
my opinion that any success built on the foundation of deceit and corruption is like
building a castle on the sand. So when the storm screams against the windshield, I will
not finch! When it comes to the kind of turbulence that brings planes down, I will be
the pilot who punches through the storm so the passengers (You the People) can
breathe again. As a successful business man I built Big Time Pest Control from the
ground up, then sold it trading upper management to serve as a chaplain, in the
trenches, kneeling hand-in-hand, with the forgotten, and the broken. My heritage is a
map of U.S. American grit, stretching from Samuel Fuller, the Doctor of the Mayfower
to the lightning rod of Ben Franklin. But I’m not looking back—I’m looking forward to all
of California, where people are feeling abandoned and betrayed! I have a plan to STOP illegal ICE operations; and
a chaplain’s heart to remember who the system serves. I’m 100% against the miles-driven tax. To Make California
Great Again, PROTECT THE PEOPLE! As the old parties are debating the heat over who bought the matches,
while the dumpster fre burns; I’m handing you a fre extinguisher! That’s why I am the best choice for Governor of
California. • www.DeMottForGovernor.com

John Harrold@abumirchi· May 5

I'm pretty sure that @kagi.com supports it. You have to pay, but at least you're not the product. kagi.com/search?q=%22...

Kagi search results for "Affinity optimization of monoclonal antibodies (mAbs) is essential for developing drug candidates"

John Harrold@abumirchi· May 4

Claude draw me a picture of econmaett.

John Harrold@abumirchi· May 2

This was three hours ago.

Screenshot of Will Stancil feeding his trolls.

John Harrold@abumirchi· Apr 28

This is an example (I also have translation built in, and I was testing it with this). You can see how the meme has text, but there is also text in the background, the persons shirt, etc. The summary is kind of funny.

Example showing a clipping tool with automated AI analysis built in. Also automated translation.

John Harrold@abumirchi· Apr 20

We're getting these in California as well.

Original messge:

State of California Department of Vehicles(DMV) Final Notice: Enforcement Penalties Begin on March 3.
Our records show that as of today, you still have an outstanding traffic ticket. In accordance with State of California Administrative Code 15C-16.003, If you do not complete payment by March 2, 2026, we will take the following actions:

1. Report to the DMV violation database
2. Suspend your vehicle registration starting March 3
3. Suspend driving privileges for 30 days
4. Transfer to a toll booth and charge a 35% service fee
5. You may be prosecuted and your credit score will be affected
Pay Now:

https://ca.org-gtavv.bond/dmv

Please pay immediately before enforcement to avoid license suspension and further legal disputes.
(Reply Y and re-open this message to click the link, or copy it to your browser.)

Response:
Oh dear. And it appears the DMV is now working out of the Philippines and using .bond instead of .ca.gov domains. What has befallen my fair state?

John Harrold@abumirchi· Apr 18

Here's an example. This is a service I created to sort of bookmark or clip things for me. If I clip a youtube video it creates a local archive and you can see the automated AI analysis below it in purple. I have it save the full transcript as well (there is a tab for it).

Galaxy brain card for Dread Zepplin A Song of Hope showing automated AI processing results.

John Harrold@abumirchi· Apr 14

Killtopia Phantoms #1 just showed up on my porch from @davecook.bsky.social

Picture of two killtopia comics: Phantoms #1 and Anthology 001

John Harrold@abumirchi· Apr 11

Is this what you're looking for?

Jay Campbell is a prominent figure in the field of hormonal optimization and therapeutic peptides. He is a five-time international bestselling author and co-founder of BioLongevity Labs. Through his books, website, and media appearances, Campbell provides research and guidance on using peptides to enhance health, longevity, and physical performance.Key Books and Resources"30 Days 2 Shredz": A guide focused on rapid fat loss and body transformation."Optimize Your Health with Therapeutic Peptides": Often cited as a primary resource for those looking to understand the specific protocols for various peptides.JayCampbell.com: His official website contains deeply researched articles on hormone optimization, fitness, and spirituality.Core Concepts in Campbell's WorkHormonal Optimization: Advocates for a holistic approach to maintaining hormonal health, which often involves the discussion of peptides alongside other therapeutic interventions.Health and Longevity: Focuses on the use of various substances and lifestyle changes intended to improve physical performance and recovery.Integrated Wellness: Emphasizes that physical health optimization should be paired with mental and spiritual development.Safety and Medical ConsiderationsThe use of therapeutic peptides is a complex medical field. It is important to consider the following:Professional Consultation: Before starting any peptide regimen or hormone therapy, consulting with a qualified healthcare professional is essential. Self-administering these substances without a prescription and medical oversight can lead to serious health complications.Regulatory Status: Many peptides discussed in fitness and longevity circles are not approved by regulatory bodies like the FDA or Health Canada for the purposes of fat loss or muscle building.Unauthorized Products: Buying peptides online from unauthorized sources poses significant risks, as these products may be contaminated, incorrectly labeled, or unsafe for human use.

John Harrold@abumirchi· Apr 7

This person needs some "Horn OK, Please" flair.

Back of truck in India painted with a lotus flanked by peacocks over the words HORN OK PLEASE written in all caps.

John Harrold@abumirchi· Mar 29

I've been testing this theory. I used to pay $250/year for Adobe Acrobat Pro. I only used a handful of features. So I asked Claude Code to build me a native macOS app in Swift to replace it. I'd never written Swift before.

Spindrift splash page with a wave on the left based on traditional Japanese art crashing onto a tree covered with buds and some flowers and the name spindrift below the tree.

John Harrold@abumirchi· Mar 18

I somehow have this. I don't remember where I got it though:

Screenshot of After the Astronaut from the Butthole Surfers in iTunes.

John Harrold@abumirchi· Mar 17

Just to add onto this point. The dynamic update above the headline says: Saudi Arabia says it has intercepted over a dozen drones today.

The headline says: The US-Israeli strategy against Iran is working. Here is why
Every aspect of Iran’s ability to project regional power is being successfully degraded.

Dynamic update says: Saudi Arabia says it has intercepted over a dozen drones today

John Harrold@abumirchi· Mar 16

I'll have to wait to read it, but it looks great.

Pillfreak advertisement with a woman in a bikini holding brains in the palm of her hands. This is set over a person sitting in a chair throwing pills in his mouth with an ephemeral woman standing behind him caressing his brain.

John Harrold@abumirchi· Mar 11

This shows that the CPAP machine is working what other data do I have? Here you can see the effects on O2 saturation. All figures done in #rstats and #shiny. Dataset and Shiny app were built with Claude Code.

O2 saturation with dashed line horizontal guides at greater than 95% (normal) and less than 90% (low). You can see the data dip below normal until January when I started using the CPAP and it goes up above 96%.

John Harrold@abumirchi· Mar 11

The data overlap pretty well. We can plot the common data together to see how they relate to each other. What you can see here is that the apple watch data consistently over predicts by about 2 events per hour but the slope is about 1.

Events/hr data wit Apple Watch measurements on the y-axis and CPAP measurements on the x-axis. The line of identity is there for a reference. A linear fit shows the correlation is consistently about 2 events/hr higher.

John Harrold@abumirchi· Mar 11

I put it off but managed to go to a sleep doctor at the end of last year and took an at home sleep test. I was diagnosed with sleep apnea and I got a CPAP. I've been using it for about 5 weeks now and it works pretty well. I exported the data from that and merged it with my Apple Health data.

Breathing disturbances over time (December 2025 to present) showing the decrease in breathing disturbances starting on January 25th. Yellow data from Apple Watch and the blue data are from the CPAP machine.

John Harrold@abumirchi· Mar 11

Is there anyone out there getting #sleepapnea messages from their Apple Watch and wondering if it means anything? I've always snored, and my wife thought I was stopping breathing while sleeping. I was also getting those messages from Apple Health (I wear the watch while I sleep).

Breathing disturbances over time (Jan 2025-Jan 2026) showing values greater than normal (less than 5/hr) and often elevated (greater than 15/hr)

John Harrold@abumirchi· Mar 9

By the way, this was the prompt I used:

I want to create a pdf reading and creation tool that has a subset of features
that I need from Adobe Acrobat. I want this to run as a native Mac
application. Here are the features I want are the ability to:

- Read in transparent png file and stamp them on to the pdf
with the ability to resize and move the stamps. I want to be able to resize
and move them even after I close and reopen the file.
- Fill in form variables
- Combine multiple files of different file type (pdf, image
files, etc) into a single pdf file with bookmarks for the file.
- Add comments to the file.
- Run OCR on text in document, and if the document is scanned pages overlay
that text on the pdf to make it selectable.
- The ability to edit the file including: add text boxes with controls for
font, color, size, etc; edit the text to highlight, underline, and strike
through.

John Harrold@abumirchi· Mar 4

You can see the errors that were generated below in the first tab. You can see the ticket that was generated and the container for the shiny_server was restarted and the problem fixed. All this happened before I even noticed there was an issue.

Notifications showing several services are unhealthy or unreachable.

When you click on a notification it will take you to the ticket created to address it. Here you can see that the Shiny Server was down and that it had to restart docker to address it.

John Harrold@abumirchi· Feb 28

Each user can adjust how this works by specifying reccomendation preferences in their settings. Here you can see I added Britis Crime Drama and Bollywood movies. You can also add keywords and specify languages you prefer movies to be in.

John Harrold@abumirchi· Feb 28

And I had it embed Youtube trailers for the movies as well. Everything I'm showing you here is on my own network at home. And I've consolidated everything into one place I control.