Yes, it works for me on Feedly consistently! I use this URL: www.science.org/blogs/pipeli...

Communicating better about the weaknesses and strengths of science, and being specific about how to improve it, and rejecting bad ideas, is the goal now. If your reform ideas happen to get mixed up with an OSTP that writes groveling propaganda like this, it's not time to celebrate, but to critique.

Key figure:

ohhhhh man it is another amazing paper from @masarunobu.bsky.social that's a Microgenomates growing on a Chloroflexi:

And here's another email from the DOE's Z-Division, which finds the science in the Yan Report 'credible'. It is tempting to believe that the government has top secret intelligence. In this case they were impressed by something so cringe that public conspiracy theorists are deeply embarrassed by it.

stalking this thread a bit, learning... I think you are operating on a more abstract and semantic level than many of us biologists are used to or enjoy, BUT: recently, there has been some shift in understanding host 'defense' genes as selfish elements themselves: journals.plos.org/plosbiology/...

"Binder design" tutorial coming soon...

Yeah I also don't know of any great solution here there. Here's an Opus 4.7 approach for you: gist.github.com/alexcritschr... it works *ok*, gets the numbering right in this case tho (this is *probably* a bad answer for you, but, nonetheless, thought it couldn't hurt to throw some slop at it)

I don't buy that it's really such a dichotomy myself... But it's an informative article and I think it's true that there are simply too many cows is probably a bigger problem than the cows aren't ecologically efficient enough. Good to try to fix both problems, though

Dear @virusesimmunity.bsky.social, the thoughtful engagement is here with us on bsky! 😇

oh that's very very cool:

I just caught this really interesting paper today. They obtained genomes for a new species of Treponema using genome-resolved metagenomics, associated with Noma diease:

We saw this on biorxiv last year, nice to see it published! I like their table of efficiency by strain - tough luck in some species, but still very cool.

Here are the computational biology parts of the Claude Opus 4.7 update today. Certainly impressive benchmark numbers, and likely to be an exciting model to work with in the real world if they hold up. www.anthropic.com/news/claude-... cdn.sanity.io/files/4zrzov...

Lots of great figures in this one, check them all out (also yes, sometimes I judge papers positively when they agree with my priors and untested beliefs 😇)

Absolute banger: "find that metaSPAdes consistently outperforms MEGAHIT" "Binning refinement, which combines bins from multiple different algorithms, leads to reduced performance" "We further show that CheckM2 systematically overestimates completeness and underestimates contamination"

An Asgard archaeon from a modern analog of ancient microbial mats (Current Biology) Beautiful microscopy of an Asgard archaeon, in the same family as Lokiarchaea, in syntrophy with a sulfate-reducing bacteria Very very nice paper we saw in preprint form: www.cell.com/current-biol...

Absolutely astounding paper. Massive 36,000 AA proteins facilitate cell-cell interactions in this bacterial symbiosis. Really beautiful scientific work.

I'm not at Asilomar myself, but we've started sharing a lot of our recent fungal work at fungi.cultivarium.org/image-atlas. Check out the growth timelapse videos on a dozen media for each species (here's Penicillium chrysogenum):

Weird day for microbiology

Great rally in Boston today! Here are some actions anyone can take: -- support the DRIVE Initiative, which would invest $400M in MA research+higher education -- support H.2554, which will close irresponsible loopholes in vaccine requirements for children in MA -- Protest ICE and war on March 28

If you are in the Boston area, come out and bring a friend to the common for @standupforscience.bsky.social this Saturday! There's a great speaker lineup, music, tables... will be a jam!

Really crazy that these massive genes are 6% of the 1.5 Mbp genome in this bee gut symbiont:

First Waymo spotting in Brookline today:

e.g., when you see full reads in a sample mapping to one species' mtDNA, evenly spaced, with better mappings than to other species' mtDNA evenly across the genome, there's really no question what it is at the species or sub-species level, even if it's very few reads

methods are scaring me tho - kraken on full WGS databases is a very very fuzzy approach with only a semblance of reality 😅 re-analysis could be cool!

Good thread. Another issue with the editorial is overall NIH funding is not a good measure of success. That doesn't bring back global public health cuts, the lives lost, cancer trials disrupted, vaccine research ended, diversity grants eliminated, foreign subcontracts killed, or grants disrupted.

Ktedonobacteria are so freaking cool, with 10+ Mbp genomes, interesting morphologies and tons of BGCs

mystery has been solved: It is actually New England Baptist Hospital, not NEB. You can see that logo here: www.yelp.com/biz_photos/n... And the stylized NEB square with the rose used to be on the sign: Anyhow, if you see this on facebook marketplace in Boston, be warned it's not sweet NEB gear!