Alejandro Montenegro
@aemonten
Molecular Biologist (aemonten.github.io) 丨Chief Editor @ CSH Protocols (cshprotocols.cshlp.org) 丨Head of the Integrity in Publishing Group at CSHL Press 丨Chair "Molecular Biosystems Conference" (molbiosystems.com) 丨(Oxford) Comma King 丨Central Dogma Police
A new issue of CSH Protocols is out! @cshlpress.bsky.social The cover image highlights the work by Pierce, Hostetler, & @erinsparks.bsky.social, who describe a protocol for quantifying individual root mechanics in maize using a three-point bend test 🌽 ⬇️Links below
"We show here that the protein sequence is insufficient for the biogenesis of fully active IDR-containing transcriptional regulators in cells, suggesting that mRNA 3′ UTRs control their activity by preventing co-translational misfolding" doi.org/10.1016/j.ce...
Not a single mention of the role that *academics themselves* play in maintaining this system, setting the incentives, etc 😅 The power of change lies within. journals.sagepub.com/doi/10.1177/...
"Our goal is to guide the design of experiments that balance biological relevance, sensitivity, and interpretability to ultimately answer a deceptively simple question: What TFs directly regulate the expression of my GOI?" genome.cshlp.org/content/36/3...
"This difference is as good as significant on a binomial test (p=.0502)"
I wonder how many retractions these or similar types of errors will lead to
A new issue of CSH Protocols is out! @cshlpress.bsky.social The cover image highlights the work by Char et al., who provide a comprehensive protocol for CRISPR–Cas9 gene editing in maize 🌽 ⬇️Links below
And ICMJE guidelines state that editors should check the accuracy of those tools
Ideally, you. But AI tools are already checking everything else, so yes.
First time I've seen an autographed paper www.linkedin.com/posts/peng-j...
A paper was submitted with 4 authors. During revision, the *entire* group of 4 original authors was replaced with others during revision. No explanation. The authors *disagree* with the retraction 😅
The editors resigned over this. And SN will close the title. 25% is *a lot*. On the other hand, the journal publishes 12 articles a year... retractionwatch.com/2026/06/05/n...
A new issue of CSH Protocols is out! @cshlpress.bsky.social The cover image highlights the work by Mullens et al., who describe a protocol for high-throughput inoculation of #maize leaves with C. nebraskensis, enabling large-scale field evaluations of disease resistance. 🌽 ⬇️Links below
What fraction of the human genome is essential for cellular viability? More precisely, how much of the genome is DISPENSABLE for the growth of a haploid cell line? Somewhere between 50 and 96% (nb. as expected). www.biorxiv.org/content/10.6...