Danielle Beckman

@daniellebeckman

PharmD, MS in Biophysics, PhD in Biochemistry 🇧🇷 Rio 🇺🇸 Sacramento 🇩🇪 Munich International Society of Long COVID & Post-Acute Infection Syndromes: daniellebeckman.com

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Danielle Beckman@daniellebeckman· 8d

"ICUs all over the country were empty." Tell that to the families who lost loved ones, to the exhausted healthcare workers who watched patients die day after day. Tell that to the cities forced to dig mass graves because morgues were overwhelmed. History doesn't change because someone rewrites it.

From NBC News in April 10, 2020

Video shows giant trench being dug on NYC's Hart Island to bury coronavirus victims
The public cemetery is now getting five times the usual number of unclaimed bodies every week.

Danielle Beckman@daniellebeckman· 8d

Progress happens when people work together. Honored to be part of the new International Society of Long COVID & Post-Acute Infection Syndromes (islc-pais.com). Together, we're advancing understanding, treatment, and prevention of post-infectious diseases through rigorous science. #LongCOVID #PAIS

Danielle Beckman@daniellebeckman· 11d

Seeing is understanding. That's why we're working hard to build the next generation of biomedical imaging at @deeppiction.bsky.social. Because tomorrow's cures begin with seeing what was once invisible. #FluorescenceFriday #PrecisionMedicine

Danielle Beckman@daniellebeckman· 14d

One more nail in the coffin of the "it's just deconditioning" hypothesis. 60 days of strict bed rest ≠ #LongCOVID or #MECFS. Rob's group shows that while exercise capacity may be similarly reduced, the underlying skeletal muscle biology is VERY different. Time to move beyond outdated assumptions.

Nature Communications
Article in Press
Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest

Danielle Beckman@daniellebeckman· 16d

Our review covering the major Neuroinflammatory events in Long Covid is finally online and open access here! www.nature.com/articles/s41... #NeuroCovid #LongCovid 🤓🧠

Expert Review
Open access
Published: 21 July 2026
Understanding neuroinflammation in post-COVID-19 syndrome: biological mechanisms, diagnostic biomarkers, and therapeutic prospects

Danielle Beckman@daniellebeckman· 16d

Excited to be serving on the International Abstract Committee for the 2026 ISLC-PAIS Conference in Amsterdam next month! If you have new findings on #LongCOVID, #MECFS, or #PAIS, don't miss the Late Breaking Abstract deadline on July 30. We'd love to see your work! islc-pais.org/abstract-sub...

ISLC Pais Conference Poster - Amsterdam 26-29 August 2026

Danielle Beckman@daniellebeckman· 25d

This is not AI. This is real microscopy! 🔬 An intact gut, rendered transparent and imaged in 3D using light-sheet microscopy! 🤓 Looking inside organs to investigate where pathogens, immune cells, or disease processes may persist. More at: www.nature.com/articles/s41... Happy #FluorescenceFriday!

Danielle Beckman@daniellebeckman· Jul 11

🧠 What if #LongCovid is, in part, a disorder of dopamine? Our new commentary explores how disrupted dopamine signaling may help explain fatigue, brain fog, and autonomic dysfunction, and what this could mean for future therapies. Open access link: shorturl.at/vLAfU

Article at eBiomedicine:
Dopaminergic vulnerability in long COVID: striatal PET imaging at the brain-body interface

Eric Guedja, Danielle Beckman

Danielle Beckman@daniellebeckman· Jul 10

An intact human heart, rendered transparent. Because disease doesn't happen in 2D. Whole-organ tissue clearing and light-sheet microscopy reveal coronary vessels (magenta) and atherosclerotic plaques (gold) across the intact organ. More at: shorturl.at/iqTBh 🫀🔬 #FluorescenceFriday!

Danielle Beckman@daniellebeckman· Jul 4

I had fun editing these videos 😎 Whole-body imaging is really opening new possibilities for biology. Seeing the whole picture changes the questions we can ask, and ultimately the discoveries we can make. Read more: 🔬 DISCO-seq www.biorxiv.org/content/10.6... 🚀 LipiGo www.biorxiv.org/content/10.1...

Danielle Beckman@daniellebeckman· Jun 25

Nothing else to say.

Mary Lasker’s iconic quote, "If you think research is expensive, try disease."

Danielle Beckman@daniellebeckman· Jun 22

Biology was never meant to be studied in 2D. One of the coolest things about my new work is being able to visualize: 🧠 Neural circuits 🩸 Vascular networks 🎯 Drug biodistribution 🎗️ Disease progression Here's a small glimpse of what we're building at @deeppiction.bsky.social 🤩🔬 #3DImaging

Danielle Beckman@daniellebeckman· Jun 22

As #HPV vaccine coverage continues to rise, cervical cancer deaths among young women plummeted. In the most highly vaccinated cohorts, deaths fell to ZERO. Among unvaccinated women, mortality rates barely changed. Vaccines save lives. www.thelancet.com/journals/lan...

Cervical cancer mortality trends following HPV vaccination in England, 2001–24: an analysis of population-based mortality data

Danielle Beckman@daniellebeckman· Jun 17

A recent study by @zalaly.bsky.social shows a ~40% reduction in major cardiovascular events among >1 MILLION participants after vaccines. The findings suggest the SARS-CoV jab not only protects against infection but can also reduce #LongCOVID cardiovascular issues. jamanetwork.com/journals/jam...

Image shows the title of the paper: Original Investigation
2024-2025 COVID-19 Vaccine and Major Adverse Cardiovascular Events Among US Veterans
A graph that shows the reduction of major adverse cardiovascular events (MACEs) following COVID vaccination.

Importance: COVID-19 vaccines were previously shown to reduce risk of major adverse cardiovascular events (MACEs)
Conclusions and Relevance The substantially larger reduction in all-cause MACE suggests that the vaccine’s protective association extends to the hidden burden of undetected SARS-CoV-2 and its sequelae.

Danielle Beckman@daniellebeckman· Jun 17

Not all brains age the same🧐🧠 Using whole-brain 3D imaging combined with spatial proteomics, @erturklab.bsky.social revealed multiple trajectories of cerebrovascular aging. A fascinating new study: biorxiv.org/content/10.6... I'm always excited to share great work from my colleagues! #Neuroscience

Danielle Beckman@daniellebeckman· Jun 12

Great to see @virusesimmunity.bsky.social last paper highlighted at natrevimmunol.bsky.social. One of the strongest pieces of evidence yet for autoimmunity in #LongCOVID. Not proof that autoimmunity explains all neurological Long COVID, but it's getting harder to dismiss as one important mechanism.

Image shows the title of the article: Pathological potential of autoantibodies in long COVID, and the text:
Using mice with fluorescently labelled pain-sensing neurons to explore the potential mechanisms of pathogenicity, the authors found that mice receiving long COVID IgG exhibited a reduction in intraepidermal nerve fibres (a hallmark of small fibre neuropathy) alongside increased circulating neurofilament light chain, consistent with axonal injury. Whole-brain mapping with iDISCO imaging revealed widespread neuronal activation after IgG transfer across areas associated with pain perception, fatigue, emotional regulation and cognition. These findings
suggest that circulating autoantibodies can access neural tissues and perturb both sensory pathways and higher-order brain networks. The finding that patient IgG is sufficient to induce disease-relevant phenotypes in mice raises the possibility that therapies that target circulating antibodies could ameliorate some symptoms of long COVID and suggests that autoimmunity is one mechanistic axis for long COVID, among others.

Danielle Beckman@daniellebeckman· Jun 11

And sadly these numbers are very conservative. They are back from 2024, when the ONS gave up monitoring 🙄.

Estimated number of children suffering from Long covid:
March 2023: 62,000 (England, Scotland, Wales and N Ireland)
March 2024: 118,816 (England & Scotland only)

Danielle Beckman@daniellebeckman· Jun 10

2026 update: pig semen eye drops exist. GTA 6 still doesn't.

Nature news: Eye drops made from pig semen deliver cancer treatment to mice
Minuscule particles with the ability to cross hard-to-penetrate barriers can be loaded with drug treatments to target intractable diseases.

Danielle Beckman@daniellebeckman· Jun 10

Danielle Beckman@daniellebeckman· Jun 10

“If the cells are frequently turning over but there is still viral persistence, what other plausible explanations are there for this other than replication?” That's a very good question someone asked, let's do a thread about VIRAL PERSISTENCE in #LongCovid to cover this! (1/10)

Image shows that Viral persistence is one of the potential causes of Long Covid, together with reactivation of latent viruses, multi-tissue damage/autoimmunity, disturbance in gut microbiota, and viral superantigen activation of the immune system

Danielle Beckman@daniellebeckman· Jun 10

Bad news: many kids under 8 never received the original Wuhan #COVID vaccines. Their immunity was shaped mostly by Omicron infections. New data suggest the "Cicada" variant (BA.3.2.2), now re-emerging in several countries, may be particularly good at evading those antibody responses.

Text reads the author Yunlong Richard Cao's tweet: Our latest preprint is out, where we investigated a profound SARS-CoV-2 epidemiological anomaly: BA.3.2.2 is selectively infecting children. Here, we show that the lack of ancestral-strain immune imprinting is promoting BA.3.2.2 pediatric infections.

Danielle Beckman@daniellebeckman· Jun 9

Happy birthday to Michael J. Fox! His foundation invested more in #Parkinson research than the U.S. government itself. "Optimism is a political act." In a world full of uncertainty, setbacks, and reasons to give up, choosing optimism is an act of courage. Video: Too Young for this Sh*t Podcast

Danielle Beckman@daniellebeckman· Jun 9

C'mon @wired.com, you have a chance to do better. Instead of amplifying pseudoscience, why not talk to the patients living with #LongCovid and the researchers studying its biology? Levinovitz is not a physician, neuroscientist, or virologist. His expertise is in religion. Try again!

Alan Levinotvitz, author of the journalist article about Long Covid at Wired.
He is also the author of "The Gluten Lie" and "Natural". He is an assistant professor of philosophy at James Madison University. Levinovitz shared insight about the connection between religious thinking and dietary philosophy, and the importance of virtue of uncertainty as a guiding character trait.

Danielle Beckman@daniellebeckman· Jun 8

The anatomical proximity and direct connection between the olfactory bulb and the orbital prefrontal cortex (OFC) make it a key neuroinvasion route for #COVID in the brain. In patients with #NeuroCovid, we observe thrombotic events, hypometabolism and atrophy in this region.

The image shows a text that reads:
The orbitofrontal cortex (OFC) is part of the olfactory cortex. Also controls emotions, reward value, reward-related decision-making, and inhibitory behavior
Damage to the OFC can lead to disinhibition, characterized by perseveration (repeated actions), reduced reversal ability (difficulty adapting to changing rules) and impulsive choices.

Followed by microscopy images showing Cerebral microhemorrhages (CMHs) in the OFC after COVID-19 infection

Danielle Beckman@daniellebeckman· Jun 8

Let's rip the band-aid off

Figure of a human brain with a text that reads: All quiet on the frontal lobe

Danielle Beckman@daniellebeckman· Jun 8

Happy to share that, after a prolonged peer-review process, our review on the major Neuroinflammatory events in #LongCovid was accepted for publication in Translational Psychiatry by @natureportfolio.nature.com! Coming out soon, but preprint available here: www.preprints.org/manuscript/2...

Title of the review article: Understanding Neuroinflammation in Post-COVID-19 Syndrome: Biological Mechanisms, Diagnostic Biomarkers, and Therapeutic Prospects, by Daniel Martins ,Danielle Beckman,Marco Loggia,Alessandra Constanza,Alessandra Borsini

Danielle Beckman@daniellebeckman· May 30

How it feels moving to a new country that you don't speak the language

Message shared from *Freud.intensifies* that reads: If anyone has any experience with anything or knows anything about something please let me know

Danielle Beckman@daniellebeckman· May 29

Not all organs respond equally to #COVID infection. DISCO-seq, a new technique led by my talented friend @harsharanbhatia.bsky.social, combines 3D imaging and single-cell analysis to map Spike Protein tropism and found mostly in the liver, lungs, intestine & kidneys www.biorxiv.org/content/10.6...

Danielle Beckman@daniellebeckman· May 28

Is #LongCovid going away? Data show it is not. In a cohort study with 457.950 Covid cases, 1 in 6 patients developed Long Covid. Prevalence is 13-23% of US population, increasing 0.4%-1.5% every 3 months. Cases remained stable through 2022 but started to increase in late 2023.

Study: Long COVID Persistence and Surveillance Gaps Across 58 US Hospitals
Conclusions and Relevance In this cohort study, approximately 1 in 6 patients with COVID-19 developed PASC, and 89.31% of these patients had at least 1 chronic condition. Current diagnostic coding captured fewer than one-half of the cases, obscuring a substantial chronic disease burden. The persistently increasing prevalence through 2024 indicated an accumulating health care burden requiring investment in surveillance infrastructure and integrated care pathways.

Danielle Beckman@daniellebeckman· May 28

My American kitties finally relaxing for the first time after realizing their Brazilian mom isn’t getting deported, she just escaped the U.S. and relocated the entire operation to Germany. 😎🐈‍⬛🐈‍⬛