Roles of NRF2 in DNA damage repair pmc.ncbi.nlm.nih.gov/articles/PMC... NRF2 plays roles in maintaining the integrity of the genome by — repairing DNA damage — regulating the cell cycle — regulating antioxidant defense 🧪 #cell #physiology #signaling

Chrononutrition & Energy Balance www.mdpi.com/2072-6643/17... Early time-restricted eating offers significant benefits: — weight control — glycemic regulation — lipid profiles — mitochondrial efficiency — even in the absence of caloric restriction 🧪 #health #lifestyle #research

Curiously, to score 100% daily, you must consume: >80 g poultry >150 g refined grain 250-400 g wine 60-400 g beer < 100 g legumes While whole fruit, whole vegetables, fish & herbs/spices are considered irrelevant! (Perhaps all artifacts of studying the UK population?) 🧪

Here's part of the transcript of the conversation of Dr. Topol with Dan Buettner, Founder and Chairman of the Board of BLUEZONES LLC.

Here's how my VO2max increased since AUGUST 2025 while performing consistent HIIT since 2016 Coincident with my supplementing #creatine + #taurine during AUG 2025, and one-month abstinence from #taurine during MAR 2026 Fascinated to encourage further physiological study of these phenomenon

Excellent & chilling article! Thanks @justinling.ca for writing & sharing!

#heart health linked to #gut health via dietary #fiber www.acc.org/Latest-in-Ca... — feeds good gut bacteria — lowers inflammation, cholesterol, blood sugar — lowers cholesterol, BP, body weight — 25-38 g fiber/d from fruits, vegetables, legumes, whole grains #cardiovascular #diet #longevity

And when you click "file a complaint" here's what you get

Yes, this website is a joke A very good joke I admit Here's what you get when you submit a paper for reformatting!

Here's the source article: Combined Effects of Diet Quality Scores & Frailty on All-Cause Mortality & Life Expectancy in Middle-Aged & Older Adults www.mdpi.com/2072-6643/17... @atanas-g-atanasov.bsky.social @science-george.bsky.social @elizabethjacobs.bsky.social @virusesimmunity.bsky.social

Republicans say the loss of enhanced tax credits are irrelevant? Here's what happens to my #ObamaCare premium: Currently $489/mo When I sign up NEXT MONTH, my premium will be $489 + $389 = $878/mo That's an 80% increase! Thank you Democrats for forcing a shut down until Republicans fix this!

I just canceled my Hulu account! Have you? I started noticing ABC news was beginning to neglect coverage of a particular news story… #standup #democracy #firstamendment #freespeech

Based on my VO2max, my 56-yo body can sprint as fast as the top 25% of men in their 20s & 30s! Curiously, I had to change my calendar age from 56 to 36 to get my fitness app to report my recent VO2max values There were 3 weeks of missing values when I began exceeding the max for my 50s age group!

Looking for a biomarker of #longevity? I recommend biomarkers of fitness & resilience Every morning, I run interval sprints for about 10 minutes to boost my VO2max Here are the VO2max values you should target based on calendar age using an Apple Watch & iPhone fitness app #health #science #aging

Curiously, shorter lifespan also associated with delaying meals to later in the day www.nature.com/articles/s43... @atanas-g-atanasov.bsky.social @science-george.bsky.social @alisyngayle.bsky.social @janelleanthro.bsky.social @drlaurahaynes.bsky.social

I like the risk factors they identified, but these are static metrics & need to be expanded to include dynamic metrics Important dynamic metrics include: > cardiovascular fitness: VO2max, sprint speed > muscle strength: push ups, pull ups, sit ups > balance: one legged stand eyes closed

Economists confirm what we already knew Democrats buy electric vehicles Tesla CEO Elon Musk’s move to right is alienating his customer base sherwood.news/tech/economi... ▶️ How do Tesla customers justify their EV purchase paying for "DRILL BABY DRILL"? ▶️ Why not sell your Tesla?

Does the building on the left look like a #resort or #prison? • Left image was edited to remove swimming pool which makes building look surprisingly frightening to me • The original image on right is Universal Terra Luna Resort in Florida They just need a moat filled with hungry alligators! 🐊🪱

Can you overdose on exercise? Finnish researchers observe a U-shaped relationship between #exercise and #aging link.springer.com/article/10.1... "participants in the sedentary and highly active classes were biologically older than those who were moderately active and active" #health #longevity

Dynamics of blood #NAD and #glutathione in #health, #disease, #aging and under NAD-booster treatment www.biorxiv.org/content/10.1... — normal distribution in blood — remain unchanged during aging — NAD-boosting increased NAD+ 4-6x — NADs & glutathiones show disease-dependent ″redox fingerprints″

⬆️ Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy @atanas-g-atanasov.bsky.social @science-george.bsky.social @sergey2023.bsky.social @agingdoc.bsky.social

Aging and longevity require avoiding accidental injury And the car you drive appears linked to injury & fatality Here is a list of cars most associated with fatal accidents. www.iseecars.com/most-dangero... 1. Are you surprised to see the Corvette & Porsche 911 ? 2. What about Tesla ? #health