New research now out in Nature Cell Biology, led by Nathaniel F. Henneman in Ganna Panasyuk team, shows that nuclear class 3 PI3K co-activates fasting-specific chromatin remodelling. Read the article here: tinyurl.com/4h4vybsb Learn more about it and about the first author: tinyurl.com/2pdbjdk7

They all have been awarded funding from the @agencerecherche.bsky.social under the #AAPG 2026 call for proposals!

📅 SAVE THE DATE | 2026 INEM Prestige Lecture Series From 1 to 4 December 2026, INEM will welcome Professor Fiona Watt, @embo.org Director and an internationally recognised leader in stem cell biology. 📍 INEM : 160 rue de Vaugirard, 75015 Paris More details on our website: tinyurl.com/kp2z4ybv

👏 A huge congratulations to Guillaume Canaud on being awarded the 2026 Mendel Medal, an award recognising his significant work on rare diseases linked to mutations in the PIK3CA gene and on the development of innovative treatments for patients! @eshg.bsky.social

New research now out in Cell Death & Disease from @natureportfolio.nature.com, led by Véronique Baud in @mario-pende.bsky.social team, shows that the alternative NF-kB RelB subunit is a novel critical sensor of lipid metabolism to promote tumor development.

New research now out in Cellular & Molecular Biology Letters, led by Edouard Le Guillou in Ganna Panasyuk team, shows that restoration of lysosomal membrane integrity in cell models of Pompe disease depends on fatty acid synthase and its product palmitic acid. tinyurl.com/ytu86hj9

New research now out in @jci.org, led by Manal Mazloum in @fabiolaterzi.bsky.social team, shows that cilia to basement membrane signalling is a biomechanical driver in models of autosomal dominant polycystic kidney disease tinyurl.com/5ahn88ns

📢 INEM Friday Seminar Series At INEM Auditorium 2 Today, Zayna Chaker from the Institute of Functional Genomics of Lyon will present her work at the INEM seminar series "The puzzle of adult brain stem cell coordination: A functional and evolutionary perspective" Details here➡️ tinyurl.com/5xmnjkpn

📢 INEM Friday Seminar Series At INEM - Auditorium 3 Today, Marat Yusupov, from IGBMC, Strasbourg, France, will present his work at the INEM seminar series "Study of ribosome structure for the development of drugs" Details here ➡️ www.institut-necker-enfants-malades.fr/node/4474

📢 INEM Friday Seminar Series Today, Robert E. Schwartz, from Weill Cornell Medical College, New York, USA, will present his work at the INEM seminar series "Vascular Identity, Stromal Diversity, and the Challenge of Building a Bioartificial Liver" Details here ➡️ tinyurl.com/szfbjmdc

Retour sur la retraite de l'INEM de ces 2 derniers jours près de Fontainebleau Les membres de l'INEM se sont réunis pour des conférences scientifiques… et vulgarisées 🎤 et pour des activités ludiques🎉 👏 Bravo aux présentateur·ices Et merci aux organisateur·rices et sponsors pour cet événement !

Le 6 mars 2026, Fabiola Terzi, directrice de l’Institut Necker Enfants Malades, a reçu la Légion d'honneur des mains de Gérard Friedlander. Une reconnaissance qui honore un parcours et les valeurs d’ouverture portées par l’INEM. Plus d'information sur le site de l'INEM : tinyurl.com/3ssxkc2b

Aujourd'hui vendredi 13 mars, l'invité du Friday Seminar à l'INEM était Aude Bernheim, chercheuse de l'Institut Pasteur. Invitée par la cellule égalité professionnelle de l'INEM, son séminaire s'intitulait "Ce que le féminisme fait découvrir à la biologie" Plus d'info ici : tinyurl.com/55jmhnh6

📢 Paris Postdocs Seminar 📅 March 5th 📍 INEM Room 4 (-1) Next week, Alexandre Pierga from @institutimagine.bsky.social will present the @parispostdocs.bsky.social "Loss of MTPAP disrupts mtRNA processing causing upregulation of type I interferon signaling" ➡️ tinyurl.com/4stwnnu7

📢 INEM Friday Seminar Series 📅 February 27th 📍 INEM Auditorium 3 Today, Gioacchino Natoli from the European Institute of Oncology, Milan will present for the INEM seminar series "Control of genic and extragenic transcription in inflammation and cancer" Details here ➡️https://tinyurl.com/3pfa6u29

📢 INEM Friday Seminar Series 📅 February 20th 📍 INEM Auditorium 3 Tomorrow, Vassili SOUMELIS from Inserm U976 HIPI will present for the INEM seminar series "Multi-Omic data for patient stratification and personalized medicine in immuno-inflammatory diseases" Details here ➡️ tinyurl.com/jezjvcab

📢 Paris Postdoc Seminar 📅 February 19th 📍 INEM Room 4 (-1) Tomorrow, Hugo Barreto from @institutcochin.bsky.social will present the @parispostdocs.bsky.social "Eco-evolutionary dynamics of bacterial strains across Human gut microbiotas" ➡️ tinyurl.com/5p82htud

📢 Journée des Fournisseurs/Supplier's Day 📅 February 17th 📍 Institut Necker Enfants Malades Next week, INEM is hosting its Supplier's Day ! Over 20 suppliers available to meet with Necker campus researchers & collaborators all day 👩‍🔬👨‍🔬 Organised by the HappyNEM association ➡️ tinyurl.com/mpekc5tb

[SEMINAR] 🗓️ Join us today, for a #seminar with Henri-Francois RENARD, group leader at Université de Namur. Pr. RENARD will explore the molecular mechanisms of clathrin-independent endocytosis. Don’t miss it! Invited by @membramics-lab.bsky.social

[SEMINAR] 📢 Paris Postdoc Seminar at INEM on Thursday January 22 Maria Lizarralde-Iragorri from @institutimagine.bsky.social will present the @parispostdocs.bsky.social seminar "Investigating Hematopoiesis and Erythropoiesis in Sickle Cell Disease" More info ➡️ tinyurl.com/ykjnp873

[PUBLICATION] The Schnupf lab shows how SFB remodel their adhesive tip during development from unicellular to filamentous forms - now out in @natcomms.nature.com 👏🏼 First author: @anaraquelcruz.bsky.social 🔗 nature.com/articles/s41467-025-66892-5 📰 Read more on INEM website: tinyurl.com/yjfvbzu2

❄️Bonne année 2026 !❄️Happy New Year!❄️ Un bonhomme de neige s’est invité devant l'INEM pour vous souhaiter le meilleur pour cette nouvelle année☃️ ✨Que vos résultats soient significatifs et que vos contrôles fonctionnent à chaque fois !✨May your results be significant and your controls always work!✨

[PUBLICATION] The @membramics-lab.bsky.social team shows how keratin is involved in melanin genome photoprotection at the cell level. 👏🏼 Co-1st authors: Silvia Benito Martinez & @laurasalavessa.bsky.social 🔗 doi.org/10.1038/s415... 📰 Read more on INEM's LinkedIn, and website: tinyurl.com/yr9pntvb

After a few months away, INEM is back on Bluesky! 📢 Paris Postdoc Seminar on Thursday Alberto Iannuzzo will present the @parispostdocs.bsky.social seminar "Deciphering the mechanisms responsible for the pathogenicity of CDC42 variants identified in autoinflammatory syndromes" ➡️ tinyurl.com/84bsf5ee

[PUBLICATION] The @membramics-lab.bsky.social shows how Influenza A virus rewires ER lipid metabolism to promote vRNP egress. 👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social journals.plos.org/plosbiology/... w/ @institutpasteur.bsky.social & IPNP @plosbiology.org

[PUBLICATION] NEW in @cp-cellreports.bsky.social @julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation. 📖 www.cell.com/cell-reports... @membramics-lab.bsky.social

[CAREER] A 3-year PhD position is open in Paris to explore how air pollution contributes to CKD. The project combines experimental and environmental science and is hosted by INEM & LISA. 📨 Apply by Sept 1. 🟢 Start Nov–Dec 2025. www.institut-necker-enfants-malades.fr/offre-demplo...

🚨 We're hiring! INEM is recruiting a Group Leader in #Immunology. Join a vibrant biomedical research institute with strong clinical & academic links. 🗓 Apply by Sept 20, 2025 🔗 More info: institut-necker-enfants-malades.fr/careers

[PUBLICATION] New study with the Bharat lab @cellbiol-mrclmb.bsky.social reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. 🦠 Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis. @mathieucoureuil.bsky.social @pnas.org www.pnas.org/doi/10.1073/...

[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key. | Canaud Lab @pnas.org 🔗https://www.pnas.org/doi/10.1073/pnas.2424867122