JCI insight
@insight
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists:
GZMK deficiency alleviates target-organ pathological injury in murine aGVHD.
GZMK-expressing tissue-resident memory CD8+ T cells participate in human intestinal acute graft-versus-host disease: doi.org/10.1172/jci....
This issue’s cover features work by Hua Jin & team on the discovery of a GZMK-expressing CD8+ T cell subset linked to severe intestinal GVHD and poorer patient outcomes after stem cell transplantation: doi.org/10.1172/jci.... Image generated using ChatGPT.
Cancers often arise in an environment characterized by fibrosis and inflammation Romain Desert et al. contribute a Review to JCI Insight’s 📗Special Issue on Fibrosis: The ECM in cancer-associated fibrosis: molecular mechanisms and clinical relevance: doi.org/10.1172/jci....
Fontan associated liver disease can occur after open-heart surgery for children with a single functional heart ventricle doi.org/10.1172/jci.... Here, Lehrich et al. identify a population of metabolically exhausted hepatocytes unique to FALD with advanced fibrosis
TGF-β coordinates alanine synthesis and import for myofibroblast differentiation in pulmonary fibrosis: doi.org/10.1172/jci....
ICYMI⭐️ William M. Oldham @willoldham.bsky.social & team discover scar-forming cells in pulmonary fibrosis rely on alanine as a metabolic building block and simultaneously blocking its synthesis & uptake suppresses fibrosis in lung tissue: doi.org/10.1172/jci.... with @edykimlab.bsky.social
Saturday Spotlight⭐️ 📗From our Special Issue on Fibrosis Robert Schwabe & colleagues provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @rkramann.bsky.social @the-asci.org
Presenting a rigorous multicohort translational study: doi.org/10.1172/jci.... Baldwin et al. @columbiamed.bsky.social report on a blood protein that identifies people with lasting lung scarring after COVID19 & reveal ongoing airway cell changes that may drive fibrosis years after infection.
Multi-omics analysis reveals dermokine as a regulator of keratinocyte differentiation and adhesion: doi.org/10.1172/jci....
When wound healing gets stuck Chiara Francavilla & team identify a molecular signal in non-healing wounds that links dermokine with cell-cell adhesion: doi.org/10.1172/jci....
Primary sclerosing cholangitis is a progressive liver disease marked by periductal pathology doi.org/10.1172/jci.... Yunguan Wang & team find a communication axis involving stellate cells & macrophages around bile ducts implicated in driving liver fibrosis in pediatric patients
📗A Review from our Special Issue on Fibrosis: doi.org/10.1172/jci.... The inflammatory/fibrotic axis across organs: myelofibrosis as a model of reversibility by Greven et al.
📗From our Special Issue on Fibrosis Robert Schwabe & colleagues provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @the-asci.org
Spotlight: 📗From our Special Issue on Fibrosis Benjamin D. Humphreys @humphreyslab.bsky.social provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @the-asci.org
Longitudinal multiorgan transcriptomic atlas of salt-induced hypertension: doi.org/10.1172/jci....
ICYMI: How does organ injury that’s caused by salt-related hypertension progress? doi.org/10.1172/jci.... Here, Alexander Staruschenko & team mapped gene changes across organs over time in a rat model, revealing shared and tissue-specific pathways and potential targets for precision therapies.
Behind the scenes: The Cheng lab celebrates their publication with a lunch outing.
Symptoms often persist after surgical treatment for Hirschsprung disease doi.org/10.1172/jci.... Here, Lily S. Cheng & team report increased fibrosis, stiffness & alterations in ECM composition may contribute to persistent dysfunction of the ganglionic intestine in HSCR.
📗From our Special Issue on Fibrosis Benjamin D. Humphreys @humphreyslab.bsky.social provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @the-asci.org
Behind the scenes: meet the team from the Shimizu lab and the place they call home.
📗Special Issue on Fibrosis Curated by Editors Gavin Arteel and Melanie Königshoff The cover, from Ippei Shimizu & team: PCPE-1 promotes cardiac fibrosis with aging and obesity, was generated using Google Gemini, representing fibrotic cardiac tissue. doi.org/10.1172/jci....
Presenting a detailed examination of 77 isolates of the human malaria parasite Plasmodium malariae from 4 African countries: doi.org/10.1172/jci.... @zachpopkin-hall.bsky.social & team find that P. malariaie is atypical among human malaria for low levels of genetic diversity.
Aortic rupture is a major risk in vascular Ehlers-Danlos syndrome doi.org/10.1172/jci.... @elenamacfarlane.bsky.social & team find inhibition of androgen & mineralocorticoid receptor signaling improves survival in mice by upregulating ECM organization and cell-ECM interactions
A biopsy-based observational study on the effects of age in kidney transplants: doi.org/10.1172/jci.... Halloran & team report older donor age correlates with more injury and lower function in kidney transplants, but the actual impact of age on function and survival is small.
Providing an important dataset to the field of dermatology: doi.org/10.1172/jci.... In this Research Letter, Qing-Sheng Mi & team find tunnels in hidradenitis suppurativa have a transcriptional signature like mucosal epithelia that may contribute to inflammation in the condition.
PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension: doi.org/10.1172/jci....
Achieving tissue-specific & time-dependent genetic manipulation in mice: doi.org/10.1172/jci.... Benjamin R. Thomson @thomsonlab.bsky.social & team report on a nanoparticle-assisted approach in which PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension
Glioblastoma cancer stem cells are vulnerable to WDR5 inhibition, but current inhibitors have limited blood-brain barrier passage. Here, Justin D. Lathia & team provide proof-of-concept that WDR5-inhbitors can be redesigned for improved BBB permeability: doi.org/10.1172/jci....
Detection of cytokine release syndrome using wearables and cytokine profiling following CAR-T therapy for myeloma: doi.org/10.1172/jci....