💬 Viewpoint: Longitudinal precision functional mapping combines individualized brain network mapping with repeated imaging to distinguish trait-like illness markers from state-like symptom changes in #Psychiatry. ja.ma/4qartja

Family genetic risk scores across 18 psychiatric disorders indicated six correlated factors: psychotic, externalizing, anxiety, neurodevelopmental, mood, and eating disorders. ja.ma/4wWaoMz

#SelectiveSerotoninReuptakeInhibitors are an essential component of perinatal mental health care, and treatment decisions in pregnancy should balance risks of untreated major depressive disorder with benefits and potential risks of treatment. ja.ma/4hoQ4hX

Machine learning models using periodic health assessment data identified US Army soldiers at elevated risk of subsequent #Suicide and nonfatal #SuicideAttempt, with distinct predictors between the two. ja.ma/4q9KRgp

#GLP-1 receptor agonist use and misuse were common among people with #EatingDisorders, with many reporting adverse events, underscoring the need for pharmacovigilance as availability increases. ja.ma/3U8ePFp

The FDA approved gepirone extended release for #Depression based on 2 positive trials despite 11 negative or inconclusive trials, highlighting the agency's use of regulatory flexibility and trial-level statistical significance. ja.ma/4fM3gMB

Disease development trajectories in #MentalDisorders vary by diagnosis at first contact, sex, and age, with younger patients exhibiting more diagnostic shifts and psychiatric contacts, highlighting the need for targeted preventive care. ja.ma/4fNaQqs

Among #veterans with #PosttraumaticStressDisorder and distress related to killing in war, impact of killing psychotherapy improved psychosocial functioning and showed greater benefit than present-centered therapy present-centered therapy. ja.ma/3TIH65u

💬 Editorial: Reduced temporal stability of #EEG microstates shows promise as a scalable biomarker for predicting clinical outcomes in individuals at high risk for psychosis. ja.ma/45fjk3n

📝 JAMA Psychiatry #Review: Peripheral #Biomarkers in #Psychiatry depend more on study design than on analytic sophistication, with signal most likely when studies reduce confounding, select reliable phenotypes, and match biomarker use to clinical need. ja.ma/3Slfbbd

In #StimulantUseDisorder trials, no medication significantly outperformed placebo for abstinence, but cabergoline supported greater reduced cocaine use when nonabstinence outcomes were included. ja.ma/4fNbzba

💬 Viewpoint: In clinical high risk for developing #Psychosis, impaired social functioning is both a predictor of psychosis onset and a major source of disability, supporting trials that measure recovery with person-centered functional outcomes. ja.ma/4cgbuKz

📝 JAMA Psychiatry #Review: Peripheral #Biomarkers in #Psychiatry depend more on study design than on analytic sophistication, with signal most likely when studies reduce confounding, select reliable phenotypes, and match biomarker use to clinical need. ja.ma/4vU5bU0

💬 Viewpoint: In #Psychiatry, large language models should be used as clinical instruments, with clinician accountability and source-grounded verification before output influences care. ja.ma/4xcXbyL

Among adolescents in substance use disorder treatment who used nicotine #ECigarettes, urine cotinine concentrations increased abruptly beginning in October 2024. ja.ma/4hIXIUi

Among patients with prior #SexualViolence, hypervigilance remained the highest #PTSD symptom over time, while negative alterations in cognition and mood recovered most slowly. ja.ma/4wfUNXb

Dan-Mircea Mirea, PhD, and John Torous, MD, discuss how receiving more “likes” on social media posts led to greater increases in posting among users with #depression compared to those without depression. 🎧 Listen now: ja.ma/4vs61HE

Military sexual trauma prevalence remains high among US veterans, especially females, and is associated with increased risk for suicidal thoughts and behaviors. ja.ma/44lGKDV

📄JAMA Psychiatry #Review: Functional unblinding was common in most #psychedelic randomized clinical trials for psychiatric disorders, with >70% correctly identifying treatment allocation, raising concerns for trial validity. ja.ma/4vSymHT

Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/4phhfNB

Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/44lg06w

In #overweight or #obese patients with #Depression, adjunctive oral #semaglutide reduced effort discounting and improved motivation on a validated effort-expenditure task compared with placebo. ja.ma/4b5knX9

💬 Editor's Note by Dost Öngür, MD, PhD: In a randomized clinical trial, semaglutide reduced hemoglobin A1c and body weight and improved physical quality of life in patients with #schizophrenia, #prediabetes, and #obesity, w/o negative effects on mental health. ja.ma/4xZHYSH

In a nationwide Finnish cohort, adolescents exposed to peers’ mental disorder diagnoses and genetic predispositions had increased risk for later mental disorders, especially within school-based peer networks. ja.ma/4feupay

Individualized, connectivity-based targeting of accelerated transcranial magnetic stimulation produced significantly greater antidepressant effects than scalp-based targeting in adults with treatment-resistant #Depression. ja.ma/4v5sqKI

Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4eaNSIU

Disrupted gastrointestinal interoception predicted relapse and symptom severity in weight-restored females with #AnorexiaNervosa, supporting ingestible mechanosensory probes as scalable tools for monitoring and relapse prevention. ja.ma/4a4UDcM

This narrative review suggests mental disorders are statistical clusters of biopsychosocial properties, not sharply defined categories, mirroring concepts in species classification and supporting dimensional #MentalHealth frameworks. ja.ma/4xw5dDO

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns. ja.ma/4e5qlJo

Administration of ketamine during general anesthesia preserved high-frequency EEG changes but lacked low-frequency modulation, suggesting neurophysiologic components of ketamine can be selectively altered. ja.ma/4e6qA6X