“JGP is also a journal I turn to for rigorous, impactful science, and it's wonderful when scientific excellence and a commitment to equity go hand in hand.”— Theanne Griffith (@doctheagrif.bsky.social). JGP, where scientists set the course 👉 hubs.la/Q04lcxPj0

Half of muscle RyR channels lack voltage sensor contact-so how do they activate? New model from Rios and Pizarro shows that allosteric propagation through the couplon explains it all. rupress.org/jgp/article/... #Biophysics #IonChannels #ComputationalBiology #SkeletalMuscle

Howell, Xu, & Cohen (@harvard.edu) provide a framework for predicting & interpreting bioelectrical dynamics in small structures, such as bacteria, viruses, & intracellular vesicles, where they are strongly affected by stochastic gating of single #ionchannels. rupress.org/jgp/article/... #Biophysics

Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels. New Review from Philipp Schmidpeter (UTSA) and Crina Nimigean @weillcornell.bsky.social: rupress.org/jgp/article/... #Biophysics #Biochemistry #MembraneTransport #Lipids #membranes #IonChannels

Kinetic reconstruction of graded membrane excitability in #Paramecium. New tudy from Takashi Tominaga and Yoko Tominaga (Tokushima Bunri University): rupress.org/jgp/article/... #CellularPhysiology

#CallForPapers 📣 You are invited to submit papers on the topic “What’s Hot in #Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function and Disease.” Learn more & submit here 👉 rupress.org/JGP/pages/ca...

Evolution, hibernation, and inactivation of voltage-gated Na channels. New Hypothesis from John S. Willis @universityofga.bsky.social: rupress.org/jgp/article/... #IonChannels #Biochemistry #Biophysics #MolecularPhysiology #CardiacMuscle

From our July issue: rupress.org/jgp/issue/15... Representative images of HEK293 cells transfected with a membrane marker (red), Kv1.3-YFP (green), and KCNE4-CFP variants (blue). From Magalí Colomer-Molera, Daniel Sastre, and Antonio Felipe @ub.edu: doi.org/10.1085/jgp....

Conformational changes upon pore blocker removal reveal conductive states of TMEM16A. New study from Christina A. Stephens, Frank V. Marcoline, Christian J. Peters (University of Illinois College of Medicine), and Michael Grabe (UCSF): rupress.org/jgp/article/... #ProteinStructure #ProteinDynamics

Hearts of hibernating mammals continue to beat at near 0°C thanks to continued excitability. Several members of a minor group of voltage-gated Na channels in the heart are found to contain a mutation unique to hibernators. From John S. Willis @universityofga.bsky.social: rupress.org/jgp/article/...

Takashi Tominaga and Yoko Tominaga develop a kinetic framework for the major membrane-current components in #Paramecium. The framework integrates late-component, leak, and inward Ca2⁺ currents, including Ca2⁺-dependent inactivation and slow recovery. rupress.org/jgp/article/...

Label-free real-time imaging of mitochondrial matrix volume changes and permeability transition in living cells. New Methods and Approaches from Yaw Akosah, Paolo Bernardi, Evgeny V. Pavlov and colleagues (New York University): rupress.org/jgp/article/... #CellBiology #Mitochondria

On the mechanism of #hypomagnesemia with treatment-resistant seizures caused by variants of the Na⁺,K⁺-ATPase α1 subunit (ATP1A1). New study from Nicolas Colmano, Daniel Self, Pablo Artigas (Texas Tech University Health Sciences Center) and colleagues: rupress.org/jgp/article/... #Biophysics

📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV. New study by Maxime Lammens, Frank Bosmans et al. (Ghent University) rupress.org/jgp/article/... #IonChannels #Biophysics #MolecularPharmacology

Our July issue is here! rupress.org/jgp/issue/15... The cover shows neural coding in the electrosensory system of weakly electric fish. From Amin Akhshi, Maurice J. Chacron, Anmar Khadra et al. doi.org/10.1085/jgp....

Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity. New study from Héctor Gaitán-Peñas, Salomé Llabrés, Marina Pedrola, Rodolfo Lavilla, Raul Estevez and colleagues @ub.edu: rupress.org/jgp/article/... #ComputationalBiology #ChlorideChannels

An #epilepsy-associated Kᵥ3.1 potassium channel variant acts via dominant positive effect. New study from Jerome Clatot, Ethan M. Goldberg @ethangoldberg.bsky.social and colleagues @childrensphila.bsky.social: rupress.org/jgp/article/... #IonChannels #Biophysics #Pathophysiology

Along with membrane potential and respiration, mitochondrial matrix volume is a critical parameter that is linked to physiological and pathological states. Akosah et al. present an assay for detection of the dynamic changes in mitochondrial matrix volume in living cells. rupress.org/jgp/article/...

Na/K pump α1 subunit variants cause several disease phenotypes. Colmano, Self, Artigas et al. show that all variants known to cause hypomagnesemia and seizures carry aberrant leak currents and have both reduced function and reduced plasmalemma expression. rupress.org/jgp/article/...

Regulation of olfactory chloride and cyclic nucleotide-gated channels by cholesterol. New study from Samsudeen Ponissery Saidu, Alexander Kross, Michele Dibattista, Katharina Gaus, and Johannes Reisert (Monell Chemical Senses Center): rupress.org/jgp/article/... #Lipids #IonChannels #Biophysics

Gaitán-Peñas, Llabrés, Pedrola, Lavilla, Estevez et al. @ub.edu show that DCPIB inhibition of volume-regulated anion channels does not depend on a single residue but relies on adaptable binding modes combining electrostatic and hydrophobic interactions. rupress.org/jgp/article/...

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions. New study from Sofia F. Nazarova, Vadim А. Alekhin, Nikolay S. Ilyinsky (Moscow Institute of Physics and Technology) et al.: rupress.org/jgp/article/... #ComputationalBiology #Biophysics #Lysosomes

Publishing in JGP enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: 👉 rupress.org/pages/nih-hh...

Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of #SkeletalMuscle fatigue. @rainbowlabuol.bsky.social and @richardbj.bsky.social discuss new work from Scala and Chen et al. @colinnicholslab.bsky.social (rupress.org/jgp/article/...): rupress.org/jgp/article/...

Unfurling the role of dysferlin's C2A domain. New work from Lukyanenko, Muriel, Weisleder, Bloch et al. (rupress.org/jgp/article/...) featured in our latest Research News: rupress.org/jgp/article/...

Nazarova, Alekhin, Ilyinsky et al. present an interactive model of lysosomal ion homeostasis that remains robust during different biologically relevant stresses. rupress.org/jgp/article/... #Lysosomes #Biophysics #ComputationalBiology #CellularPhysiology #MembraneTransport

At JGP, editorial decisions are made by active researchers who dedicate time to thorough peer review, ensuring evaluation is based purely on research quality. Learn how scientists set the course and join Dr. Okamura in publishing your paper in JGP: hubs.la/Q048xDZ70

Rainbow and Barrett-Jolley discuss Scala et al. (rupress.org/jgp/article/...), who demonstrated that Kir6.2/SUR2-containing KATP potassium #IonChannels are the functionally relevant isoform that modulate contractile behavior of fast-twitch muscle during fatigue. (1/2) rupress.org/jgp/article/...

Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets. New review form Shimon Schuldiner @hebrewuniversity.bsky.social: rupress.org/jgp/article/... #Biochemistry #Biophysics #CellularPhysiology #Lipids #membranes #Neuroscience