Mary Lyon Centre at MRC Harwell
@mrcharwell
The UK’s national facility for mouse genetics and the use of mouse models for the pre-clinical study of human disease
#Training: Cryopreservation allows long-term storage of embryos and sperm, providing a convenient way to preserve, protect, and transport your mouse line, as well as removing the need for continued animal breeding. Book your place on our Cryopreservation course now!
#Training: Join us in October for our 2-day Mouse Necropsy and Tissue Processing course to learn how to perform a basic standard mouse necropsy, as well as how to treat collected tissues in preparation for histological processing and embedding:
Want to understand genetic drift and how to maintain integrity in both simple and complex genetically altered mouse lines? Book your place on our 3-day Mouse Genetics and Colony Management for Researchers course and join us in October!
#Training: Our Practical Laboratory Skills course covers basic theoretical and practical lab skills, including use of standard equipment, such as biosafety cabinets, centrifuges, pipettes, and balances We have multiple dates through the year, including 18th November:
#Training: Our Laboratory Skills for Animal Technicians course is for #technicians who would like to develop their lab skills, including processing blood samples, dose calculations, and use of standard equipment. Join us in October:
#Training: Book your place on our Mouse Necropsy practical training course to learn how to perform a basic standard mouse necropsy and describe gross observations made during this process This course is running again in November. Book now!
Today is Be Open about Animal Research Day #BOARD26. We are committed to openness and transparency about our use of animals, so today we are sharing our recently updated annual statistics for animal use at the MLC in 2025. www.har.mrc.ac.uk/news/use-of-...
#Training: Our Practical Laboratory Skills course covers basic theoretical and practical lab skills, including use of standard equipment, such as biosafety cabinets, centrifuges, pipettes, and balances We have multiple dates through the year, including 15th July:
#Training: Laboratory management is a subject that is often learned on the job, with limited training opportunities for those new to the role. This course is aimed at both researchers new to management and managers new to the lab setting.
Want to understand genetic drift and how to maintain integrity in both simple and complex genetically altered mouse lines? Book your place on our 3-day Mouse Genetics and Colony Management for Researchers course and join us in October!
#Training: Book your place on our Mouse Necropsy practical training course to learn how to perform a basic standard mouse necropsy and describe gross observations made during this process This course is running again in November. Book now!
#Training: Our new 2-day Using Conditional Transgenic Models course is designed for anyone using or planning to use conditional models and will equip trainees with a clear understanding of how these models function biologically, as well as the practical ways in which they can fail. Join us in July:
#Training: Our Practical Laboratory Skills course covers basic theoretical and practical lab skills, including use of standard equipment, such as biosafety cabinets, centrifuges, pipettes, and balances We have multiple dates through the year, including 15th July:
#Training: Cryopreservation allows long-term storage of embryos and sperm, providing a convenient way to preserve, protect, and transport your mouse line, as well as removing the need for continued animal breeding. Book your place on our Cryopreservation course now!
#Training: Our Laboratory Skills for Animal Technicians course is for #technicians who would like to develop their lab skills, including processing blood samples, dose calculations, and use of standard equipment. Join us in June:
#Training: Our Practical Laboratory Skills course covers basic theoretical and practical lab skills, including use of standard equipment, such as biosafety cabinets, centrifuges, pipettes, and balances We have multiple dates through the year, including 13th May and 15th July:
#Training: Our new 2-day Using Conditional Transgenic Models course is designed for anyone using or planning to use conditional models and will equip trainees with a clear understanding of how these models function biologically, as well as the practical ways in which they can fail. Join us in July:
#Training: Basic lab skills are key to high quality, reproducible research. Our Practical Laboratory Skills course covers a range of basic skills, including use of standard equipment, such as centrifuges, balances, pipettes, and fume hoods We have multiple dates scheduled, including 13th May:
Our very own Michelle Stewart was presenting training initiatives at an #INFRAFRONTIER #INFRAPLUS meeting yesterday
Last week we held our Mouse Embryo and Sperm Cryopreservation course for the 34th time, this time with delegates from Lancaster, Leeds, and Kuwait! Thanks to all our colleagues who helped make the course such a success!
@lydiateboul.bsky.social at #FELASA2025 reports on the recent development of the lag-r.org guidelines, an international for the correct and standardised reporting of animal models’ genetic makeup. This system will have a significant impact on #reproducibility and #rigour. Great attendance! #LAG-R
Sharing what we know again! Decades of experience distilled into a workshop at #FELASA2025 in which, our senior team talk about how to reduce severity of animal procedures right from the start of a project using GA mice, and limiting welfare issues. #3Rs #AnimalWelfare #training
The MRC and the @mrcharwell.bsky.social were a strong presence at the @ox.ac.uk Biomedical Services Research Delivery Day, From Insight to Impact: Delivering Research for Real-World Change, a full day dedicated to cutting-edge research, fostering collaboration between researchers and research cores
Arl13bCerulean-Fucci2a is a fluorescent cilia and cell cycle biosensor that allows live imaging of cell cycle progression and cilia assembly/disassembly kinetics in cells and mice. archive.har.mrc.ac.uk/stock?id=9690 #MouseMuse #Cilia #CellCycle Image source: doi.org/10.1016/j.de...
Today we are delighted to host RYUSEI MAEDA from our long standing friend and collaborator Toru Takeo’s lab in Japan. It’s great to find out about his work and interest in science communication as he spends a bit of time in our labs. And it’sa full lecture room! #collaboration #ReproductiveBiology
The genetic cause for hearing loss due to otitis media with effusion was investigated in a recent panel of #DownSyndrome (DS) #MouseModels. Find the DS mouse models used in the study in the National Mouse Archive #MouseMuse #WorldDownSyndromeDay archive.har.mrc.ac.uk/stock?id=6435
Thymosin β4 knockout mice have been used to study vascular smooth muscle cell development, vascular wall stability and podocyte cytoskeleton in glomerular disease. Find more phenotypic information via the National Mouse Archive: archive.har.mrc.ac.uk/stock?id=1572 #MouseMuse
#RareDiseaseDay Visit the National Mouse Archive for mouse strains useful for investigating #RareDiseases, including Marshall-Smith Syndrome, which is characterized by abnormal bone maturation, developmental delay, and distinctive facial features #MouseMuse archive.har.mrc.ac.uk/search?s=Nfix
We are ready to have some fun and let you know what we do and why! @festivaloftomorrow.bsky.social #FestivalOfTomorrow
Find us at the #FestivalOfTomorrow 2025! We are going to be at The Deanery Academy, in Wichelstowe, Swindon, for the Festival Finale tomorrow and Saturday. Come say hello 👋 and find out how we use models to better understand human disease! Book your tickets now: www.festivaloftomorrow.com