The American Society for Clinical Investigation
@the-asci
The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry. Take action for federal funding of research:
Meet our 2026 ASCI Postbaccalaureate (Postbac) Scholars. Congratulations Madelyn Blake and Luisa Morgan!
Meet the 2026-2027 ASCI PSSF Fellows! Our 5 Fellows were drawn from an exceedingly talented group of candidates nominated by their medical school dean.
📣Now open: ASCI nominations for active and international membership for 2027 may be submitted Deadline: September 10, 2026, 11:59 pm EST. buff.ly/wmMYast
📣📣Announcing 🎉🎉 Kevin N. Sheth, MD, receives the 2026 Bruce F. Scharschmidt and Peggy S. Crawford Translational Medicine Award. In this highlight, Dr. Kevin Navin Sheth offers some words for the aspiring physician scientist. For the full interview with Dr. Anna Greka: youtu.be/lcaHk_Y9VKM
Interview article: doi.org/10.1172/JCI2...
📣📣Announcing 🎉🎉 Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award In this video highlight, Dr. Zikherman discusses important factors during her training time. The full interview with ASCI President-Elect Dr. Julie A. Bastarache: youtu.be/TwsTQ8O4XZw
ASCI member Rosas et al. report on its contribution to the profibrotic responses in activated lung fibroblasts & show macropinocytosis inhibition has potent anti-fibrotic effects in pulmonary fibrosis models: doi.org/10.1172/JCI1...
Endothelial cell glycogen synthase kinase 3β promotes lipotoxic endotheliopathy and liver inflammation in MASH: doi.org/10.1172/jci....
Positioning GSK3β as a promising therapeutic target for MASH: doi.org/10.1172/jci.... Here, ASCI member Samar H. Ibrahim & team report lipotoxic GSK3β activation in LSECs drives mitochondrial dysfunction and fibroinflammation in MASH.
Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell renewal in idiopathic pulmonary fibrosis: doi.org/10.1172/JCI1...
NAD+ deficiency is associated with lung fibrosis Here, ASCI member Paul W. Noble & team boost a key NAD+ enzyme, NAMPT, to restore lung cell regeneration and reduce fibrosis, offering a potential treatment for idiopathic pulmonary fibrosis: doi.org/10.1172/JCI1...
A tribute to Eugene Braunwald (1929- 2026) by ASCI member Douglas E. Vaughan: doi.org/10.1172/JCI2... “A simple statement captures it best: cardiology before Braunwald and cardiology after Braunwald are not the same field.”
Interview article: doi.org/10.1172/JCI2...
📣📣Announcing🎉🎉 Joseph C. Wu receives the 2026 ASCI/Stanley J. Korsmeyer Award Here are some highlights of Dr. Wu discussing his seminal contributions to the understanding and application of human iPSCs in cardiovascular disease from the interview with ASCI President Dr. Priscilla Y. Hsue.
Revealing a paradox behind the failure of vaccines that target virulence factors: doi.org/10.1172/jci.... ASCI member George Y. Liu & team find the efficacy of vaccines against S. aureus α toxin is reduced in aged mice due to senescence-related loss of toxin virulence function
ASCI member Albert R. La Spada & team show cell-free DNA isolated from blood of patients with amyotrophic lateral sclerosis has epigenetic methylation features that can accurately diagnose ALS and potentially predict disease progression: doi.org/10.1172/JCI1...
From improvised to intentional: Re-Imagining the physician-scientist career path: doi.org/10.1172/jci.... ASCI member Kyu Rhee & colleagues discuss the physician-scientist career at its crossroads, drawing from the 2025 ASCI/AAIM/BWF Workshop.
Tucatinib impairs proline biosynthesis and inhibits the proliferation of glioblastoma stem cells.
The interaction between FAM3C and SPIN1 proteins to prevent the lysosomal degradation of SPIN1 and promote the nuclear localization of SPIN1.
A strategy that destroys breast cancers in mice: doi.org/10.1172/jci.... ASCI member Eric J. Sorscher & team use ICIs in combination with an E. coli enzyme-based focal gene therapy to enhance tumor clearance and ablate tumor-supporting cells in the microenvironment.
📣📣Announcing Frederick Kofi Korley receives the 2026 ASCI/Louis W. Sullivan, MD, Award. Watch highlights from the interview with Stephen Y. Chan, and view the full conversation on YouTube: youtu.be/nsFj5tUKyEs
Metabolic reprogramming is critical to microglial activation in Huntington’s disease: doi.org/10.1172/jci....
Metformin holds promise in Huntington’s disease: doi.org/10.1172/jci.... ASCI member Robert M. Friedlander & team report metformin regulates mitochondrial fission, reprograms deregulated metabolism in microglia, & controls microglial activation & inflammation in HD mice.
Liver-derived ceramides link metabolism to tissue wasting in cancer cachexia: doi.org/10.1172/JCI2... ASCI member Kerui Huang, Norbert Perrimon & Marcus D. Goncalves provide a Commentary on Morigny et al.: doi.org/10.1172/JCI1...
NET formation has been described in the TME doi.org/10.1172/JCI1... Here, ASCI member Lei Zheng & team find anti-CXCR2 antibody overcomes the NETosis-mediated resistance to MEK inhibition treatment in pancreatic cancer models by blocking infiltration of TANs to hypoxic/necrotic areas.
TLR2 signaling regulates T cell exclusion in pancreatic ductal adenocarcinoma
Towards improving immunotherapy outcomes in pancreatic cancer: doi.org/10.1172/jci.... ASCI member Gregory L. Beatty & team identify TLR2 as a driver of immune suppression in pancreatic cancer and show blocking TLR2 enables T cell entry and slows tumor growth in mice.
ASCI member Manish J. Butte @manishbutte.bsky.social & team report severe Valley fever occurring in males often features heightened allergy-like immunity, predisposed in some by genetic mutations, which suggests that targeted immune treatments can strengthen defenses: doi.org/10.1172/jci....
ASCI member Manish J. Butte @manishbutte.bsky.social & team find that severe Valley fever is linked to a weakened immune response, pointing to treatments that could re-energize the body’s defenses: doi.org/10.1172/jci....
Two Research articles in this issue explore immune phenotypes from individuals with coccidioidomycosis including those with severe, life-threatening disease: doi.org/10.1172/jci.... & doi.org/10.1172/jci....