Spread the word! Registration is open for The Physics of Life at the Nanoscale meeting at the Aspen Center for Physics, Jan 3-8, 2027! This is an evolution of the popular Single Molecule Biophysics meetings (SMB). As always, there is a two step registration. Registration closes on Sept. 15, 2026!

Futurama is hitting very close to home this season...

Congratulations to Isiah (and his mentor Ray) for completing the STEM Catalyst Program @uwmadscience.bsky.social!

I think we are 290-300 at the moment... I've felt sick all day.

After 15 years, I was finally able to convince my lab to have our summer outing at The House on the Rock...

Wonderful seeing everyone at Joanne Stubbe's birthday party the week before last!

Celebrating Alex's birthday and having @uwmadscience.bsky.social well-represented at the @biochemsoc.bsky.social #MachinesonGenes meeting in Crete!

It was wonderful to catch up with former labmates at JoAnne Stubbe's 80th birthday party on Saturday!

Heading to Boston soon to celebrate my graduate advisor's (and former @uwbiochem.bsky.social faculty member) birthday. Happy birthday JS! Here she is celebrating with some @uwmadison.bsky.social Babcock Dairy ice cream (orange custard chocolate chip of course!)

Le Tour de RNA was an awesome success! Thanks to everyone who helped us celebrate Sam, RNA, and NMR!

Thanks to all of our sponsors!

Can't wait for the 43rd Steenbock Symposium "Le Tour de RNA" on Saturday!

In feel-good news, congratulations to Paige and Ben for winning Hilldale Undergraduate Research Fellowships!

Amazing photos of the storms yesterday in Madison (and the aftermath). This one was by Crystal Pearson and found via the link below. No AI involved! The weather was really bonkers yesterday afternoon/evening. www.channel3000.com/news/news-3-...

Forgot to post this! 2 current Hoskins Lab undergrads (Ellie and Antonio) connect with a former undergrad (Charlie) and @uwbiochem.bsky.social major who is now a scientist at Merck!

Wrapping up the semester with our last RNA Maxigroup talk featuring Blake Wiedenheft! Thanks to @bmolchem.bsky.social @uwbiochem.bsky.social and @rnasociety.bsky.social for sponsoring!

I'm speculating that one outcome of Prp2 remodeling is a shift in the U2 snRNA (esp. around U2 G20) that allows for Cwc15 peptide insertion. Thus, Cwc15 could "mark" a correctly (?) assembled and activated spliceosome catalytic center.

The take home story is that Cwc15 fine tune's the active site, likely explaining its impact on alternative splicing in organisms ranging from potatoes to cows.

We find that Cwc15 seems primarily to be involved in formation of the spliceosome active site responsible for 5' splice site cleavage as well as promoting that reaction itself. This isn't too surprising given the protein's location proximal to the U2/U6 disnRNA.

Well, this was a weather alert I hadn't seen before... So far about a foot of snow and counting.

Fantastic job at #ASBMB26 by Hoskins lab undergrads presenting their posters!

Former Hoskins Lab undergrad and @uwbiochem.bsky.social biochemistry major David Beier kills it at #ASBMB2026 with his work from the Pat O'Brien lab at Michigan!

Awesome representation from @uwmadscience.bsky.social at the @asbmb.bsky.social #ASBMB2026 meeting in DC! #ScienceServesUsAll

Thank you to our Wisconsin senators and representatives staffs for meeting with us! #ASBMBAdvocates

Big day ahead for #ASBMBAdvocates and the Ohio and Wisconsin delegation!

Already time for the next Maxigroup! Can't wait to host @oawlab.bsky.social to talk about mechanisms and therapies related to splicing & cancer! Next Tues, March 3 at 5:30pm! Thanks to @bmolchem.bsky.social @uwbiochem.bsky.social the CMB program and @rnasociety.bsky.social for sponsorship!

Brielle and Paige representing the Hoskins Lab undergrads at the @biophysicalsoc.bsky.social poster session at #BPS2026!

Plus I saw MY undergrad research mentor Andy LiWang!

Plus honorary member Michael Palo a @uwbiochem.bsky.social undergrad and former Landick Lab member