Daniel Drucker
@danieljdrucker
A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
Challenged by the complexity of explaining GLP-1 medicines to friends and family? Gustav Hållén the talented producer of Zero Order has figured it out. Have a listen www.youtube.com/watch?v=VCIW...
New experimental insights into vagal mechanisms triggered by allulose to improve insulin sensitivity diabetesjournals.org/diabetes/art...
A potentially targetable pathogenic signature of EV-associated miRNAs capable of stratifying type 1 diabetes risk #islets @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Although #weightloss is highly beneficial to reduce fat and inflammation in the liver, posthoc analysis of the ESSENCE trial reveals substantial weight loss-independent benefits of semaglutide #MASH How does this happen?
A new review on GIP from the experts. While the narrative clearly highlights GIPR agonism suppresses food intake, the Figure implies GIP increases food intake diabetesjournals.org/care/article...
Towards actionable ascertainment of #diabetes risk in cluster subtypes with #weightloss diabetesjournals.org/diabetes/art...
Happy birthday to Professor Emeritus Bernie Zinman, newly elected member of the @CdnMedHallFame @uoftmedicine @SinaiHealth www.cdnmedhall.ca/bernard-zinm... #diabetes @DiabetesCanada
As the therapeutic benefits of GLP-1 medicines expand, the interest in the weight loss independent contributions continues to unfold linkinghub.elsevier.com/retrieve/pii...
Here the authors propose repurposing readily accessible DPP-4 inhibitors to enhance anti-tumor CD8+ T cell responses #cancer www.biorxiv.org/content/10.6...
Associations in humans suggest that Hyperglucagonemia in the face of higher hepatic lipid content in early #T2D is not due to differences in insulin sensitivity or glucagonotropic metabolites but could suggest hepatic glucagon resistance diabetesjournals.org/care/article...
Increasing options for patients with a choice of new oral GLP-1 medicines is a welcome development. The competitive messaging is well underway for oral semaglutide vs. Orforglipron #weightloss #tolerability www.novonordisk.com/news-and-med...
The 2026 Canada GairdnerAwards Laureates from Cryo-EM to amyloid aggregation,systems proteomics, cholera control, bacterial immunity, BP control after spinalinjury #Science www.newswire.ca/news-release...
A continuous intravenous LEAP2 infusion for 5 hrs reduces glycemia and food intake in men with #obesity diabetesjournals.org/diabetes/art...
In the ATLAS data semaglutide-induced downregulation of PTPRU & genetically reduced PTPRU function promote greater #weightloss This gene has no previous known functional relationship to weight loss or related metabolic functions. www.cell.com/cell/fulltex... #genetics @cp-cell.bsky.social
An open-source web atlas of all orphan oGPCR expression in the human brain to serve as a neuro-resource for the broader scientific community. www.biorxiv.org/content/10.6...
The primary cilium functions as a non-redundant signaling compartment essential for GLP-1R action in islet beta cells www.sciencedirect.com/science/arti...
Preclinical and clinical exploration of dual GLP-1R-GLP-2R agonism for metabolic disease via PG-102 www.nature.com/articles/s41...
A. muciniphila VHAKM enhances GLP-1 secretion in a strain- and form-dependent manner, with live cells showing superior efficacy www.biorxiv.org/content/10.6...
P3 40 week data for Retatrutide in people with #T2D #diabetes investor.lilly.com/news-release... #weightloss
An update on new clinical trial data for setmelanotide in rare genetic forms of #obesity ir.rhythmtx.com/news-release...
Here the authors propose that treatment of adipocytes with BMPs results in an energy expending phenotype without transdifferentiation into beige adipocytes, providing a new approach to treat #obesity related metabolic disease. insight.jci.org/articles/vie...
Postmenopausal #osteoporosis Should some individuals with rapid #weightloss on GLP-1 medicines #obesity consider anti-resorptive therapy on top of lifestyle management? How to prospectively identify candidates? academic.oup.com/edrv/advance...
Blautia wexlerae affects host metabolic control in part through #mcrobiota metabolites stimulating GLP-1 secretion www.biorxiv.org/content/10.6...
Under severe inflammatory conditions such as LPS administration, pancreatic production of GLP-1 functions in an immunological rather than a metabolic role to directly regulate local macrophage accumulation www.mdpi.com/2073-4409/15... mdpi-res.com/cells/cells-...
Safety first-new analyses of B12-compounded Tirzepatide investor.lilly.com/node/53991/pdf
@AmDiabetesAssn names superb scientists recipients of the 2026 Banting Medal, Prof Takashi Kadowaki, and the Outstanding Scientific Achievement Award, Prof Timo Müller www.prnewswire.com/news-release...
Studies in Drosophila reveal that the Akh (glucagon-mimetic) signaling pathway provides new understanding of the regulatory mechanisms between metabolic disease and cardiac arrhythmia. elifesciences.org/articles/94512 iiif.elifesciences.org/lax:94512%2F...
In normal healthy human male subjects, acute GIP infusion does not modulate splanchnic blood flow academic.oup.com/jcem/advance...